No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Researchers Hunt Causes of Non-responsive Celiac Disease

Celiac.com 03/18/2009 - A recent study used lactulose hydrogen-breath assays to show that small intestine bacterial overgrowth (SIBO) is likely a routine cause of non-responsive celiac disease.

A team of researchers from the Mayo Clinic College of Medicine recently set out to assess the rates and significance of SIBO in celiac disease based on the results of quantitative culture of intestinal aspirate.

The team was made up of Alberto Rubio-Tapia, M.D., Susan H. Barton, M.D., Joseph A. Murray, M.D., of the Mayo’s Division of Gastroenterology and Hepatology, and Jon E. Rosenblatt, M.D., of the Mayo’s department of Laboratory Medicine and Pathology. Their efforts were supported by the American College of Gastroenterology (ACG) International Training Grant 2006 (ART) and the NIH grants DK-57892 and DK-070031 (JAM).

Currently, the rate of SIBO in celiac disease diagnosed by quantitative culture of intestinal aspirate is not known. The team set out to assess the rate and determine the significance of SIBO in celiac disease based on the results of quantitative culture of intestinal aspirate.

Ads by Google:

The team set out to examine the causes of non-responsive celiac disease by looking at people with celiac disease in whom culture of intestinal aspirate was assessed for the presence of both aerobic and anaerobic bacteria. They defined bacterial overgrowth as culture >105 colony forming units/mL.

In all, they evaluated 149 people with biopsy-confirmed celiac disease. They took intestinal aspirate samples from 79 (53%) patients with non-responsive celiac disease, 47 (32%) as initial work-up for mal-absorption, and in 23 (15%) with asymptomatic treated celiac disease.

The team diagnosed 14 cases of SIBO (9.3%), nine cases of non-responsive celiac disease (11%), five cases at initial work-up for mal-absorption (11%), and 0 cases in asymptomatic treated celiac disease. Patients with a positive culture showed signs of worse mal-absorption. 67% of patients with both non-responsive CD and bacterial overgrowth showed a coexistent disorder.

The results showed that nearly 1 in 10 celiac patients had SIBO as diagnosed by quantitative culture of intestinal aspirate (9.3%). This figure included both patients with symptomatic treated or untreated CD. This shows that SIBO may exist along with other maladies associated with non-responsive celiac disease.

Journal of Clinical Gastroenterology: Volume 43(2)February 2009pp 157-161

Celiac.com welcomes your comments below (registration is NOT required).












4 Responses:

 
barbara l. frazier
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
25 Mar 2009 5:25:41 AM PDT
This is the best site for gluten free information. Thank you for making it available to us.

 
Deborah Cox
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
25 Mar 2009 5:36:10 AM PDT
Very informative - I have biopsy-confirmed celiac as well.

 
Kathleen Schweiker
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
25 Mar 2009 6:13:25 AM PDT
Would like more information. What other conditions were present among comorbid and asymptomatic patients, particularly if any were diagnosed with Chron's disease.

 
Janis
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
25 Mar 2009 7:45:36 AM PDT
Does SIBO cause bad breath and 'coverage of stuff' on your tongue that I have to use a tongue scarper on daily.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I buy the Chex cereals( except wheat). I had recently been buying Puffins from Barbara's bakery but got a very unsatisfactory answer to my question about where they source their oats so I have decided to stop buying them. See below.... "Thank you for your recent email about the oat flour in ...

Hey guys! I have been suffering from NCGS for almost a year, and have recently been diagnosed with IBS. Although I was finally getting used to the gluten free routine, this has been really hard to get used to. I'm currently having a major flare, so I'm off pretty much all fodmaps (al...

Great advice everyone! So the envirokids gorillla munch by natures path is safe?. As for cinnamon Chex is that ok too?

Alright, so I'm 3 months into being gluten free, And in terms of how I feel, the "best fit" line on the graph would be a very slow incline, which is good, but day to day, I would mark as all over the place. I don't understand. I pretty much do the same things every day, and eat the same thin...

Ha, Ha!!!!!! If I wouldn't get in trouble for practicing without a license, I would! I get it because that is what they did to me for years. I never had acid reflux but had enough other symptoms that all screamed Celiac but no.........they told me that my severe stomach pain might be a...