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Effects of Age and Gluten-free Diet on Celiac Disease



Celiac.com 08/22/2011 - Research has shown that infants with celiac disease have microscopic changes to the intestinal tract, as compared to adults with the disease.

A research team recently examined bacterial differences in the upper small intestine in healthy adults with untreated celiac disease, healthy adults with celiac disease treated with a gluten-free diet, and children with untreated celiac disease, and children with celiac disease treated with a gluten-free diet.

The research team included E. Nistal, A. Caminero, A. R.  Herrán, L. Arias, S. Vivas, J. M. de Morales, S. Calleja, L. E. de Miera, P. Arroyo, J. Casqueiro. They are affiliated with the Área de Microbiología, Facultad de Biología y Ciencias Ambientales, Universidad de León, León, Spain.

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The team used 16S rRNA gene sequencing of DNA extracted from duodenal biopsies to identify the status of their subjects. The gene sequences from adults and children showed that this intestinal region is colonized by bacteria of three different phyla: Firmicutes, Proteobacteria, and Bacteroidetes.

In total, the team identified 89 different bacterial genera in adults and 46 in children. Children showed significantly lower bacterial richness than did adults. Analysis of the bacterial communities of both healthy and untreated celiac disease patient groups (including both children and adults) showed age to have a strong effect on principal component 1 (clustering all adults and children separately), as well as a possible separate clustering in adults with untreated celiac disease.

The study revealed bacterial differences in the upper small intestine between untreated children with celiac disease and untreated celiac adults due to age. There are differences in the upper small bacteria microbiota between treated and untreated celiac disease adults due to treatment with a gluten-free diet.

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Wish we could see her follow up studies from the last 5 years.

Thank you, Awol cast iron stomach. It's really hard to tell which ingredient(s) is the wrong one for me. I think I'll eliminate all additives as much as possible because they are unhealthy anyway and then if that doesn't work I'll eliminate corn and dairy, too.

Has anyone ever experienced issues with Bob's Red Mill products? I've noticed that their products are not certified gluten free or at least that's my assumption after reading the packages.

Odd. And I wonder why she thinks she doesn't have Celiac? But her little experiment does show that some people may be going over board with new and separate pots, etc

Interesting article. I do wonder how she was 'misdiagnosed' though and how she came to the conclusion she wasn't celiac.