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Can Enzyme Supplements Really Break Down Gluten? 11/02/2011 - With the rise in celiac disease diagnoses, increasing awareness of gluten-free issues, and an explosion of gluten-free related products, it is no surprise that supplements claiming to break down gluten would find their way onto the market.

In fact, a number of supplements currently on the market claim to do just that: to break down gluten after it has been consumed.

Photo: CC--ITA Image LibraryAre these claims accurate? Are these products in any way helpful for people following a gluten-free diet? Finally, do these supplements offer a safe alternative to a gluten-free diet for people who suffer from celiac disease and/or gluten-sensitivity?

For example, GlutenEase, made by Enzymedica Inc., contains a blend of enzymes, including amylase, glucoamylase and dipeptidyl peptidase-4 (DDP-IV) — that are intended to "digest both gluten and casein, a protein found in milk," according to the company.

The website for GlutenEase says that the supplement can "support" people who have trouble digesting gluten. However, and most importantly, the site says that GlutenEase is "not formulated" for people with celiac disease.

Gluten Defense, made by Enzymatic Therapy Inc., contains a similar blend of enzymes that includes DDP-IV, lactase and amylase.

The site for Gluten Defense says the product is "specifically formulated to defend against hidden gluten" that can cause gas, bloating and indigestion.

But what does that mean? Does that mean that taking the supplement might offer people with celiac disease some extra protection against accidental gluten contamination? That seems doubtful, and unproven from a scientific standpoint.

Unlike GlutenEase, Gluten Defense offers no specific disclaimer for people with celiac disease. There is also no claim that the product is safe, or in any way formulated for people with celiac disease.

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Dave Barton, whose title is "Director of Education" for Enzymedica, claims that many people who say they have celiac disease see improvement when taking product, and that some even manage to begin eating wheat again.

However, Barton is quick to warn consumers that there's "no way to guarantee that it would break down 100% of gluten proteins."

But that's the problem isn't it? It would need to break down nearly all of the gluten proteins in order for those proteins to not cause damage to the person with celiac disease.

The fact is that these enzyme supplements may break down a few molecules of gluten protein, but no supplement exists that will make it safe for people with celiac disease to eat gluten again.

According to Dr. Stefano Guandalini, professor of pediatrics and director of the University of Chicago Celiac Disease Center, "[t]he amount of gluten that these would be able to digest is ridiculously low. For people with celiac disease, these are something to completely avoid."

Dr. Peter Green, director of the Columbia University's Celiac Disease Center, agrees that current enzyme supplements would digest only a small percentage of gluten molecules.

However, Green adds, the basic concept is sound. Pharmaceutical companies are spending hundreds of millions of dollars to create an enzyme-based drug that would permit people with celiac disease to consume gluten. However, Green points out, the companies wouldn't be spending that money if a successful over-the-counter alternative already existed.

Bottom line: Enzymes currently claiming to help break down gluten protein will not permit people with celiac disease to safely consume products made with wheat, rye or barley. Any benefit these enzymes may provide for people with celiac disease is strictly theoretical, and likely minimal at best.

A completely gluten-free diet is currently the only proven treatment for celiac disease. Talk with your doctor before making any changes to your gluten-free diet for celiac disease treatment.

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18 Responses:

Maureen McCabe
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said this on
04 Nov 2011 6:08:03 AM PDT
I had celiac disease as a child and took enzyme pills. This would have been in the 1960s.

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said this on
04 Nov 2011 10:12:10 AM PDT
Very good information, especially since there seems to be a new "gluten enzyme" tablet appearing every month or so.

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said this on
05 Nov 2011 9:29:24 AM PDT
I don't know if these products work, though they may be helpful for people with mild non-celiac gluten intolerance or for anyone with gluten intolerance who gets an accidental exposure. But I wanted to respond to your comment:

"Pharmaceutical companies are spending hundreds of millions of dollars to create an enzyme-based drug that would permit people with celiac disease to consume gluten. However...the companies wouldn't be spending that money if a successful over-the-counter alternative already existed."

Unfortunately, this is completely untrue. Pharmaceutical companies have the goal of making money and they can't make money off of supplements because they can't patent them. So not only do they spend countless dollars creating drugs to do things that supplements may already do, they also spend money to create versions of supplements that they can call drugs and patent. Then they spend countless more dollars convincing doctors and medical organizations that supplements don't work, unless it's their version, and that only prescription products are appropriate.

So I wouldn't make assumptions about the credibility of an OTC product based on what pharmaceutical companies choose to do. What I would like to see are some studies testing the enzyme products in a variety of real world situations, as well as in more controlled ways.

Though at this point I'd be happy to see even a solid collection of anecdotes, since those don't seem to be out there (I don't count what's on the companies' websites). I was hoping your article would start this process, but it seems to be mostly guesswork.

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said this on
07 Nov 2011 5:53:42 AM PDT
I don't know if it is true that "companies would not be spending that money if a successful over the counter product existed." Over the counter plant based enzymes can't be patented so often they have to isolate the components to make a drug that can make money. There are ton of prescription and over the counter medications that are based on the active ingredient is a herb or supplement that is isolated. For instance Deplin, a drug for depression, is just a form of folate you can buy as a supplement. The supplement existed before Deplin made it a pharmaceutical. The company that makes deplin just did the research studies to prove it worked. So, just to reiterated, companies do take products that already exist and make them drugs to bring to mainstream markets. Great article. Thanks.

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said this on
07 Nov 2011 5:03:51 PM PDT
Anecdotally, Gluten Defense has helped our family suffer less from contamination issues when eating out. Of course it doesn't let you go and knowingly eat gluten, it's not claiming to do that and anyone who does that is just silly. We know the only treatment is a life-long gluten free diet. But in terms of minimizing discomfort when you want to go out for a meal with friends or something, I think it's helpful.

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said this on
08 Nov 2011 1:34:58 AM PDT
Good article, Jeff. I actually take the digestive enzymes from Enzymedica currently for regular meals, but I too find the idea of digesting the gluten enzymes to be a BAD thing to market. Not only does this give those of us with celiac the false impression that it is safe to consume some wheat again, but at best this product would help ease symptoms of "accidental" glutening through cross contamination and what not.

I wish America in general would get off of the "wheat, corn, and soy or bust" mentality that leads to these kinds of product developments for Celiac's. Sure, I'm sure most of us are crying on the inside with the loss of wheat (2 years gluten free myself), but after all we're forced to learn when trying to heal we know how unhealthy wheat can be.

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said this on
08 Nov 2011 6:16:54 AM PDT
I keep some of the supplements in my purse and take some if I think there might be a chance I was exposed to gluten accidentally. I figure, what the heck, it might help, who knows? I would never purposefully eat gluten and then try to counter it with these products, though.

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said this on
08 Nov 2011 8:10:49 AM PDT
All I can say is that my husband has not had his biopsy yet, so unsure if celiac, but he DEFINITELY has a gluten intolerance. He has used Gluten-ese when he has consumed accidental gluten (a contaminated food), and if he takes it at the first sign of problems - as soon as he realizes there is an issue - the symptoms quickly subside. I am not saying that damage wasn't done, but he believes that it helps minimize it. He now also takes it if we go out to eat. He will still order gluten free foods, but this helps him in case of cross-contamination, which seems to happen more often than not in restaurants....

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said this on
08 Nov 2011 6:53:22 PM PDT
After breaking out in dermatitis herpetiformis and the usual bowel distress the last 2 times I tried to eat in restaurants that assured me my food was gluten free I've learned I simply can never eat in restaurants. This makes life difficult to say the least as it limits any traveling. If this would help to neutralize that unsuspected crumb in my food because of cross contamination in a restaurant kitchen it would be worth using. I would like to know if used for that purpose if it is effective. I might risk supposedly gluten free restaurant food again if it is.

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said this on
12 Nov 2011 8:20:16 AM PDT
I am in the same situation. The DH makes us much more aware of what we are consuming, but it makes it impossible to eat in anything except a gluten free establishment. I also would love to have something that would keep minute amounts from getting into my system and causing my DH to react.

Jeff Kelly
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said this on
13 Nov 2011 5:35:15 AM PDT
The emphasis on safety is extremely well placed in this article and those thinking otherwise are only kidding themselves. Of course, Stanford University has been working on two types of enzymes for years. And even though I agree the basic concept is sound--in practice this may not be the best and most likely--if and when it can get to market--the larezotide acetate(ie, zonulin blocker) will do the trick, but there again, only if taken properly to cover mealtimes. We all need to keep on Teva Pharm. to keep the ball rolling for AT1001!!(Alba->Cephalon->Teva: company rights purchase history).

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said this on
18 Nov 2011 2:54:16 PM PDT
Maybe the people in the celiac community should conduct our own trials using these enzymes, since no one wants to commit to anything working except a gluten-free diet! It makes me so mad every time I read that line... Like we don't know that we can't eat bread! We just want to be able to eat gluten free meals without added fear of cross-contamination! I have read many positive reviews of these enzyme products from people using them as that "safety-net." My husband is a university student who eats at the dining hall. He hasn't been able to go a week at school without cross-contamination! He verifies every item with the chef, who has been so kind as to start labeling things GF, but still can't go a week without the migraines, narcolepsy, and GI symptoms. I bought [an enzyme brand] for him two weeks ago and he hasn't had an issue since.
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said this on
13 Dec 2011 2:03:00 PM PDT
I take these enzymes every time I eat out to avoid cross contamination. Even though waiters/waitresses try, sometimes I get poisoned. These enzymes really help me if I take them with a meal. I still order all gluten free.

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said this on
17 May 2012 9:25:58 AM PDT
"The fact is that these enzyme supplements may break down a few molecules of gluten protein, but no supplement exists that will make it safe for people with celiac disease to eat gluten again."

Admittedly I'm as skeptical as the author is, but this is not a fact. There is no scientific evidence that proves that these enzyme breaks down only 'a few molecules of gluten protein'.

More investigation is needed to study the role of these enzymes, especially how they work within the GI tract before anyone should completely dismiss it.

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said this on
30 Sep 2012 7:56:20 PM PDT
This info was great. I've been trying to decide if I want to try enzymes. After reading some of the posts I'm going to do it. Eating out has been nearly impossible. My husband is a CEO of a hospital and his job requires us to take people to dinner meetings and I keep getting sick from cross contamination. I never eat out unless I have to but I hope the enzymes help.

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said this on
19 Dec 2012 4:01:43 AM PDT
I think the main thing is digesting blood bound whole proteins, something that supplements could do fairly easily. If you're taking it 3 times a day, your blood will not be burdened by it. Personally, I think papain or bromelain could do this cheaper. This is really how enzymes work, and it's a mistake to think it should try and digest the actual meal. Even so, whether this will help mild, mid or severe celiacs is only gonna be known by trying it.

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said this on
05 Apr 2013 3:07:29 PM PDT
I take them and as long as I take one and actually pour it on the food and swallow another one, I do great. I have noticed that I feel a lot better from many hidden gluten products. I don't sell these.


said this on
19 Aug 2013 3:55:53 PM PDT
I'm beginning to wonder if enzyme deficiencies are really the bodies signallying to us that we have over consumed.

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All Activity Celiac Disease & Gluten-Free Diet Forum - All Activity

JaneWhoLovesRain, what is odder to me than that there is an older disease that Doctor's have forgotten that explains many of the same symptom's and doctor's do not even think about it today since the "War on Pellagra" was declared over a 100 years and why doctor's don't (at least in the West) think about it any more. Dr. Heaney wrote a nice online article about this topic. Here is fairly recent article about how Pellagra can present in patients and the title says' it all from the International Journal of Dermatology. Dermatitis, dementia and Diarrhea are the 3 D's (4th D is death) of Pellagra. Typically it is only diagnosed today if you are in a subset of the population like an alcoholic for example or you have a gastric bypass. See this article from the New England Journal of Medicine and despite all the signs of Pellagra (skin issues etc.) . . .. Pellagra in it native tongue (Italian) where it was first diagnosed was called "rough/sour skin" who knows that today??????? Very few I would venture to guess. The NEJM can only say they have "Pellagra-like dermatitis" it has been so long since any doctor's seen it they can't (with confidence) diagnose it clinically. But taking Niacinamide 3/day for 6 months can help alleviate your symptom's if indeed the DH of Celiac is the dermatitis of Pellagra being medically misdiagnosed. Here is a an article featured on about why/how Pellagra can be confused for Celiac disease. Because they haven't seen Pellagra in 75+ years no one recognizes it anymore. ****this is not medical advice. I hope this is helpful. Knitty Kitty and I are the Niacin warriors on this board. See this thread where Knitty Kitty says Niacin helped the itching of DH. If that is so then it might help your DH (if you have it) and your GI problems too if they are caused by co-morbid Pellagra. see my blog post about where I say "I had Celiac Disease and Developed Pellagra" that talks about this in more detail. Again good luck and your continued journey and I hope this is helpful. 2 Timothy 2: 7 ?Consider what I say; and the Lord give thee understanding in all things? this included. posterboy by the grace of God,

I should say I am confused about how to interpret--- Does this mean celiac or no celiac? Thank you all---I greatly appreciate it.

KathleenH, I swear by MatteosPizza and they make National Delivery. I have been known to buy them by the dozen. BellaMonica's is not a bad corn based crust. By not bad I mean "suprisingly good" that can be bought at most grocery stores. Here is there ZIP locator page to see if they are carried in your local area. I hope this is helpful. posterboy,

Hey all--have Hashimoto's and am being worked up for epigastric discomfort and IBS like symptoms--- My blood work had an IgA within the lower end of normal range, negative TTG, but weakly positive DGP. My endoscopy showed a "nodular" duodenum with the biopsy stating there was "reactive lymphoid hyperplasia"... I have a follow-up with the GI in 3 weeks. Wondering about any help?

DH wasn't linked to celiacs until 1967 from my research...