No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:



Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Childhood Celiac Disease and Functional Gastrointestinal Disorders

Photo: CC--Glenn FleishmannCeliac.com 12/15/2011 - Until now, studies have only shown a connection between celiac disease and functional gastrointestinal disorders in adults. No solid information exists regarding children.

Due to the fact that gluten-induced gut inflammation is reversible by dietary manipulation, celiac disease may offer a useful model for examining the role of inflammatory triggers in various functional gastrointestinal disorders.

Gut inflammation is a well-known cause of functional and structural changes in the central nervous system. Researchers suspect that the culprit is an abnormal afferent input from the gut. Psychological factors may play a role in triggering overt symptoms.

A research team recently set out to examine connections between childhood celiac disease and functional gastrointestinal disorder in children meeting Rome III criteria. The team included R. Turco, G. Boccia, E. Miele; E. Giannetti, R. Buonavolontà, P. Quitadamo, R. Auricchio, and A. Staiano.

Their goal was to assess the prevalence of functional gastrointestinal disorders at one year, along with the role of psychological aspects on the development of functional gastrointestinal disorders in celiac disease children.

For the study, the team enrolled a group of 36 boys and 64 girls (Total = 100 children) with celiac disease, and followed them for one year. They also assembled a control group of 56 children, 25 boys and 31 girls.

Ads by Google:

The team had all children and/or their parents complete validated questionnaires for GI symptoms, depression, and anxiety.  The team then compared GI symptoms at diagnosis and after 1 year of gluten-free diet.

The team was able to follow up on 82 of the patients with celiac disease who followed a gluten-free diet for at least one year. Of those, 23 patients  (28%) met Rome III criteria for functional gastrointestinal disorders compared with 5 of 56 (8.9%) patients from the control group (P = 0.008; χ2 = 6.8; OR: 3.97; 95% CI: 1.40–11.21).

Most of those children who met Rome III criteria for functional gastrointestinal disorders after one year on a gluten-free diet complained of GI symptoms alone; 21 of 52 children (40.3%) overall.

Children with celiac disease with FGDIs showed substantially higher levels of anxiety and depression compared to control subjects, and to celiac disease children without functional gastrointestinal disorders (P = 0.02).

The study shows that children with celiac disease, who follow a gluten-free diet for a year, have much higher rates of functional GI symptoms than do non-celiac control subjects.

The risk may be due to residual chronic inflammation, and/or to psychological factors, but further study is needed to make that determination.

Source:

Celiac.com welcomes your comments below (registration is NOT required).





Spread The Word







Related Articles



2 Responses:

 
SandraB
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
15 Dec 2011 10:40:19 AM PDT
This is very interesting because it shows a clear link between celiac disease in children and anxiety and depression. Autistic children also commonly exhibit anxiety and depression, and many parents report that a gluten free diet helps them - suggesting that gluten sensitivity may be part of the problem for at least a sub-section of autistic children.

 
sue
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
08 Jan 2013 8:39:47 AM PDT
Thanks, we have an 11 year old family member with celiac disease and IBS symptoms. I need more info.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

Oh, it definitely struck me as very odd! It also says "no significant increase in intraepithelial lymphocytes". That's their favorite word I guess! My blood work pre-biopsy also showed increase lymphocytes and my primary doctor said it usually means increased inflammation. Doing all the things I can now---filing a complaint, I've emailed my doctors to tell them I'm upset and don't think I received proper care, I'm in the process of trying to see a naturopath that diagnosed a friend of a friend w celiac. I'm going to see if i can get the other blood work done with them---and I've been gluten free for a week and a half!

There are plenty of negatives......?

I miss living in California

Some of take longer to heal. Cut yourself some slack. A busy working mother with small children is both rewarding and taxing! You know what I asked for on Mother's Day? No cooking, food prep, or cleaning. I do not want to go out (just too busy of a day for most restaurants and my fav gluten-free restaurants are a state away). I just want to take care of myself and not others. I guess I have had a history of ditching my responsibilities on Mother's Day. My SIL would watch the baby at her mother's house (with my hubby) and I would ride my bike to the beach, order a coffee and read!!!!). I celebrated Mother's Day on Saturday with my Mom. When my daughter was old enough to want to make me breakfast, I opted for lunch after my bike ride and coffee. Hang in there!

Sometimes that's almost as important as avoiding the gluten. There's times where I've not enjoyed myself because I'm more worried about the potential for getting glutened...