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The LUPUS Inflammation Model for Sickness Beginning with B-Vitamin Deficiencies in Celiac's and other Inflammation triggered diseases….

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Posterboy

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Inflammation Model for Sickness Beginning with B-Vitamin Deficiency in Celiac's and other Inflammation triggered diseases….



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AKA The LUPUS Inflammation Model or How the ignorance about nutrition is killing us today or how and

why B Vitamins are being diagnosed as genetic GI diseases like Celiac disease today

Note to blog reader :::::::) I get in the weeds sometimes...If you decide to read this anyway...don't say I didn't warn you....

from an earlier correspondence with Scott who said It would be ok? to post here in the blog area of Celiac.com

I did this research originally for myself and how the pieces finally came together....and now posting here below my collected

thoughts on this research I have done over the years...here goes nothing...with everything that is going on with COVID-19...

It seemed the right time to post it.......

Since the day I was diagnosed as a Celiac patient 12+ years ago I began to see if I could confirm my diagnosis or come

to the same conclusion based on the current available research.

It is said knowledge is power and ignorance kills or at least maims us in this case...the ignorance about nutrition

in the medical field is striking because genetics and environment mix/intersect with B-Vitamins.

I choose early on in my research the Capstone B-Vitamin --- Niacin because it has been linked to building

stomach acid in the body....it was an easy choice I thought but as I begin to make this argument it was apparent ....

this model had some holes in the barrel....

Meaning while some Celiac's can/do develop Celiac disease (in time) ...it did explain the majority of the cases.

You can read the original article here...

Now with two years more study the clinical picture has become more distinct.

I choose capstone disease...not the Cornerstone disease.

A good model is predictive (or should be)....Pellagra predicts the 25 to 30 pct of those that get DH....so I was only 1/4 to a 1/3 right?

It didn't cover the 2/3 of Celiac's who the IJCD in 2015said might go one to develop Pellagra....

and what encourage me to begin talking about Pellagra as a differential diagnosis.

First published 5 years ago in the IJCD http://pubs.sciepub.com/ijcd/3/1/6/index.html

I made the same mistake the did....I believe they identified Pellagra Sine Pellagra aka a Riboflavin deficiency as Pellagra instead.

Which is an honest mistake even for seasoned researchers because one mimics the other....

In fact, because it is a cascade reaction....one stone build’s upon the other...B-Vitamins don't happen in an uncomplicated matter.

If you have developed Pellagra a Niacin deficiency you have already developed

Pellagra Sine Pellagra (hereafter) PSP a Riboflavin deficiency.

Pellagra is like……a 3 alarm fire.....if you have it....everybody else knows you are sick....because the raging nutritional fire

in your body has broken out to the surface...and you have terrible skin rashes....IE DH etc....

The main difference between PSP and Pellagra is the level of skin involvement.....

PSP only develops skin rashes at junctions of the skin like gentalia, corners of mouth, folds of the skin etc...

You might also have hives or various not my hair/skin is on fire itching.....just whelps not itchy ones...

Today this might be called a MCAS disease 15+ years ago Prousky proved this a Niacin deficiency

orthomolecular.org/library/jom/2002/pdf/2002-v17n01-p017.pdf 

Then known as a Histadelia or known today as a Histamine Intolerance

But this the Capstone nutrient and only a 1/3 of Celiac's will ever develop DH.

By now you won't be able to develop any stomach acid.... https://www.ncbi.nlm.nih.gov/pubmed/3992169

Studied 30+ years ago.....NO stomach acid leads to DH....

But other things have happened before this happens.....Like the low Riboflavin that has triggered your PSP.

We know it is PSP because organs other than your GI system is involved like your Thyroid for example....

Low Riboflavin levels leads to low thyroid production....

In fact, the bodies ability to synthesize it's own Thyroxine can be/is a sign your body

is now low in Riboflavin... https://www.ncbi.nlm.nih.gov/pubmed/3809170

And why in part....Celiac develops/affect multiple organ systems because you have multiple vitamin deficiencies....

Like a web of life....deficiencies are connected in a cascade/feedback loop.

ONCE this feedback loop is broken your immune system begins attacking itself triggered by gluten....

The 64K question is how do we stop this auto-immune reaction from happening in the first place or can we?

If Celiac disease involves a trigger like gluten to set it off....I believe we can...it is Epigenetics....

and something that is not well understood today...even Genetics have a trigger...

we see this in many ways like how stress in Spouses of Celiac's make them have a higher rate

of diagnosis even without Celiac genes???

The environment is the trigger!

The hormone matters site does a good job of summarizing this...

https://www.hormonesmatter.com/mitochondria-energy-not-genetics-underlies-health-disease/

yet we tend to think disease is 70pct genes and only 30pct environment when it much closer to 50/50 for Celiac disease.

The latest research confirms this hypothesis....

https://www.genengnews.com/news/dna-has-relatively-little-say-in-disease-risk-usually/

quoting....

"Notice that Wishart referred to most diseases. According to Wishart and colleagues, these include many cancers,

diabetes, and Alzheimer’s. In fact, for such diseases, the genetic contribution to disease risk is just 5–10%. There are diseases,

however, for which the genetic contribution is about 40–50%.

These diseases include Crohn’s disease, celiac disease, and macular degeneration."

Now let's see if can see why this is?

We know from previous research on air pollution B-Vitamins help us fight the negative effects of our environment ....

down regulating our Immune System... https://www.sciencedaily.com/releases/2017/04/170412111211.htm

And why taking B-2 or B-3 can help those in the 2nd or 3rd phase of Celiac disease....

But yet we still have not reached the "Cornerstone" Nutrient...

Remember this a complex biological system we are dealing with --- one deficiency effects the other deficiencies....

So, we need an analysis (model) that can determine the capstone from the cornerstone....like I confused them and the IJCD did?

If this updated hypothesis (Model) is correct?

WE know B1, B2, and B3 work together to control our immune system because

their synergistic effect has been studied together. https://www.ncbi.nlm.nih.gov/pubmed/30903555

B1, B2, and B3 together protects us from our immune system.

But this doesn't tell us what (which of the B-Vitamins) is the trigger? we just know which ones it is....

if our analysis is right and it is a combination of factors/nutrient deficiencies depending on the phase of the disease...

But we do know they work in a synergistic way....

We now know and can reasonably conclude stress and the resultant inflammation is the trigger for our Celiac disease in a 50/50 manner....

Let' look at other associated diseases to see if they can help us?

Often Celiac is said to have many wicked sister/associated diseases and in our simplicity we like of them as separate diseases....

but an elegant model says/sees a connection (explains) their association.

This "Inflammation" model explains how Celiac disease can have many different "faces" or show up in other associated diseases

like Lupus as an example....because we only have ONE inflammation model in the body....presenting (being diagnosed with diffuse

symptom's in other diseases) all related to Celiac disease....because they are in different phases of the disease IE Celiac disease...

or Pellagra or PSP

or LUPUS because it is the same "Inflammation" model.

This ordered step by connection has been worked out for Lupus recently and why Lupus shows up as an associated disease

of Celiac disease because they are the same inflammation model.

https://www.eurekalert.org/pub_releases/2019-09/uoaa-hia091319.php

We know the same Interleukins involved in Lupus are also involved in Celiac disease which is instructive too us

if they are are the same disease in different stage/phases with different faces...

The reason Celiac disease has 200+ symptom's because our body uses the same Kyneurine Pathway to develop Niacin....

and by the time Pellagra show up we really are half dead...(Metabolically) speaking....this connection has been established

in human diseases effecting nearly every organ system in the body.....because Inflammation shows up everywhere in time...

after this pathway breaks down... https://www.ncbi.nlm.nih.gov/pubmed/22084578

But what start/triggers the break?

If it is not Niacin as the Capstone nutrient? (I will skip over the discussion of B-2 for brevity purposes

(which deserves it's own paper) and skip down to the Cornerstone nutrient.....Thiamine aka Vitamin B1

Think of your body like an engine for a moment....every ICE (Internal Combustion Engine) has a Top Dead Center (TDC)

IE firing order etc....the way the engine runs smoothly and in tune...mess with the firing sequence...

and the engine won't run at alll......and the same is so for the Krebs’s cycle...

It is a robust but fragile cycle that let's make our own energy from our food....like chlorophyll for photosynthesis....

Magnesium and Thiamine are the TDC of the Krebs cycle...

(Again to make this short as possible I will not elaborate on the role Magnesium plays in this analysis but only mention in passing

(like a spark plug) for analogy purposes the engine won't run without gas....and magnesium acts like a spark plug/catalysis for us

to use our Thiamine (gas) for energy in the cell)....

Lonsdale says Magnesium and Thiamine are the keys to disease... https://www.ncbi.nlm.nih.gov/pubmed/25542071

This analysis is based on the key neurotransmitter Acetylcholine that regulates our biofeedback system in the body that triggers

our immune system in the body.

Note: to Celiac.com forum/blog readers much of the above was written free hand...as I collected my thoughts some of the remaining

thoughts have been shared first with Ch88 or Knitty Kitty and EnnisTx (in a piece meal fashion) haven written these thoughts out

before (but not shared publicly) I am collecting them here for others to research, test out and prove, contest and confirm with more research...

but consider it as always (2 Timothy 2:7) and the Lord give you understand (and have your medical experts (doctor's))

review this idea as plausible....

This analysis stands and falls on Acetylcholine....and how we can't make it without Thiamine...

when we get low in thiamine ...the acetylcholine (link) is what breaks...that put's our body in an alarm state...

but we get low in thiamine FIRST...

the low thiamine causes thin villi and leads to lactose intolerance etc...

see this research entitled "Effect of dietary thiamin deficiency on intestinal functions in rats.

" https://www.ncbi.nlm.nih.gov/pubmed/6465054

the role of acetylcholine was recently confirmed as the triggering mechanism to alert our body to go into alert mode

or auto-immune mode by triggering inflammation in our tissues/organs etc..

https://www.medicalnewstoday.com/articles/321624.php

and how the use of Baking Soda can help tame this auto-immune effect by turning off this alarm mode for the body...

Baking Soda can mitigate this alarm mode by triggering the stomach to produce more stomach acid...

And since acetylcholine is one of three triggering mechanism in the stomach in the production of stomach acid along

with Histamine they (and gastrin ) I believe regulate when we produce stomach acid and why being low in thiamine lead

to be low in stomach acid...but not completely disabling our stomach acid production....Niacin does that...

But we are in limp home mode at this point... and auto-immune system is now triggered...

Because Thiamine is used in the synthesis of Acetylcholine and it's role in the Parasympathetic Nervous System organs

through out the whole body are affected...

See this Wikipedia figure that expands how this simple neurotransmitter is used in multiple organs in the body

not just the brain (at the name implies)

https://en.wikipedia.org/wiki/Acetylcholine#/media/File:1503_Connections_of_the_Parasympathetic_Nervous_System.jpg

since Acetylcholine is used by the intestines to regulate our smooth muscle tissues (think peristalsic action of GI tract)

often times the GI tract is the first place people notice it...medical definition of peristalsis.... "the wormlike movement by which

the alimentary canal IE (the GI tract) or other tubular organs with both longitudinal and circular muscle fibers propel their contents,

consisting of a wave of contraction passing along the tube"

see this great overview on how thiamine effects the body...on the health supplements guide website...

https://healthsupplementsnutritionalguide.com/vitamin-b1/

quoting how Acetylcholine is used to regulate key organ systems including the Brain, Heart and GI tract....

"11. used by the nervous system to ensure normal muscle tone of the heart, stomach and intestines" causing intermittent

constipation and diarrhea...

People don’t' put 2+2 together because we think these complex systems are acting independently but the

Parasympathetic Nervous system (as a neurotransmitter acetylcholine) connects them all...

But this research shows how low thiamine status leads to an interruption of Acetylcholine production by the body...

and not surprisingly it is 30 years old and a generation has forgot about it...entitled "Impairment of acetylcholine synthesis in

thiamine deficient rats developed by prolonged tea consumption"

https://www.sciencedirect.com/science/article/abs/pii/0024320584906258

For must humans we don't consume enough "sweet" tea to trigger this ...but more than 6 to 8 or more cups of coffee a day...

could do it..as an example....

The reason most humans develop Beri Beri is a high CARB load....not just high wheat etc....

Anybody that (is lacking protein in a well balanced diet) could on a high (SAD) diet could develop Beri Beri (fatigue etc.)

PSP (thyroid problems) Skin Issues (DH, Pellagra etc.)...as the diseases pile on ever more symptom's...

Pharmacy Times has a nice article about Thiamine, Magnesium and Obesity on this topic....

https://www.pharmacytimes.com/contributor/adam-remick/2018/07/thiamine-and-magnesium-in-obesity-a-possible-factor-in-disease-prevention-and-co-treatment

this article has a nice overview as well... https://www.eonutrition.co.uk/blog/thiamine-deficiency-a-major-cause-of-sibo

In fact, up to a 1/3 of patients obese enough to have gastric bypass surgery due to an over reliance to CARBS in their diet

triggering sub-clinical Beri Beri... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352173/

Now people (Celiac's) just need to get tested for it....to confirm this analysis???

But be aware tests can be tricky...because they often test for the wrong things...It is much quicker to take a high quality

supplement like Benfotiamine than to confirm a Beri Beri diagnosis because the symptom's are so diffuse and common

in other diseases today the doctor's don’t' recognize Beri Beri anymore as a separate disease unless you are drinking...

Here are more resources from the hormones matters website that might be helpful to you...

http://www.hormonesmatter.com/thiamine-deficiency-testing-understanding-labs/ https://www.hormonesmatter.com/navigating-thiamine-supplements/

As I told EnnisTx....doctor's are much more likely when your 1/3 to a 1/2 dead today like in emergency room today...

https://www.sciencedirect.com/science/article/pii/S0872817813001197

When diagnosed in Celiac's ....they term it a "rare" condition (as usual) because they rarely recognize it today ...

and even Celiac's have a claim too it .....it is called a Celiac Crisis....

I say it is a crisis today that B-Vitamins deficiencies like Thiamine, Riboflavin, and Niacin are not being diagnoses

and worse tested for these deficiencies so the real rate of this high calorie malnutrition is being diagnosed and treated so people

can get better from these (often) misdiagnosed disease in Celiac disease....

Beri Beri being the Cornerstone for the Cascade (house of cards) to come tumbling down.

I know it was in my case....burning feet (pins and needles), Creatine in Kidneys, Angular Cheilitis, begins of a thyroid problems,

chronic fatigue, low stomach acid, lingering constipation and diarrhea, Low T, chronic fatigue all got better with a B-complex

and/or B-1, B-2 and B-3 supplementation....

And I now know after 12+ years of research that low Thiamine was the beginning of the cascade causing thin Villi,

leading in time to Leaky Gut...

I hope this is helpful....share with as many Celiac experts as you think would listen,

this is about educating others...."For to Educate is to Free"

Tests need to be done to confirm the years of research I've done so it can benefit other still suffering....

and all I ever wanted to do....

I just hope it is not another 20+ years before doctor's begin testing for these nutritional deficiencies in Celiac's...

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

Note: For the intrepid reader still reading this blog post....I have tried to make this as exhaustive as possible

(but you can stop reading now if you want) what follows is additional resources added later (after I composed this blog post/originally

meant as two separate posts) but presented here today as a long, rambling post in the eclectic posterboy style....

I am known for...see references for more study for yourself below..

PART 2 References

Micronutrient deficiencies in inflammatory bowel disease trivial or crucial like IBS and Chrons one third have a thiamine deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863043/

1/3 develop a thiamine deficiency …..the other 1/3 develop Chronic Fatigue etc…or Beri Beri..

Thiamine and fatigue in inflammatory bowel diseases an open label pilot study

albumin synthesis, increased albumin breakdown, a redistribution of

albumin in body fluids and greater losses of albumin can all contribute to lower serum levels with the stress response.

Forum/Blog reader: I had all these things …..but it was being diagnosed as part of my Celiac disease….

Chronic Fatigue (Magnesium and Thiamine) , Burning Feet, Depression etc….Low Albumin levels (for an unknown reason) etc….

and they all got better after taking Thiamine (undiagnosed Beri Beri)….at one point from complications in my diabetes….

I had creatine in my kidney’s now it is under control…

To demonstrate that fatigue and other disorders related to ulcerative colitis and Crohn's disease are the manifestation of an

intracellular mild thiamine deficiency and not due to malabsorbtion, augmented

https://www.ncbi.nlm.nih.gov/pubmed/23379830

 

Gastrointestinal beriberi a forme fruste of Wernickes encephalopathy in India BMJ Case report?

https://www.ncbi.nlm.nih.gov/pubmed/29982183

 

The difference between a thiamine deficiency and Beri Beri….reference work by Lonsdale

A Review of the Biochemistry Metabolism and Clinical Benefits of Thiamine and Its Derivatives Lonsdale knitty kitty

Reference work on the difference between a thiamine deficiency and Beri Beri….

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1375232/

 

Useful resources::::::::::)

Things added on the 2nd day

Lays out Stress Response in the body and how Interleukins help manage this in the body….

about Albumin Deficiency and Cytokine production….see paragraph on stress response in the body

https://healthfully.com/albumin-deficiency-8042757.html

 

Stress Response

Hypoalbuminemia is often caused by an acute or chronic inflammatory response to stress. Infections, surgery, trauma or burns

can lead to an increase in cytokine release and reduced albumin production. Decreased albumin synthesis, increased albumin breakdown,

****I apologize for the length of this post.....this even too long for me...I (usually as noted above might break this into 2 or 3 blog posts)

but with what is happening right now in our society and the world with Corona virus...WE never know how long the outbreak might last

or who it might effect....so in case I don't make back it to the forum (or another posterboy blog post) for awhile.... I unloaded the kitchen sink...

in hopes it might help the next person who has similar symptom's and/is being misdiagnosed/or going undiagnosed like I was for so.....soooo....

many years! If this helps anybody in anyway....praise God! ....I know must will never finish this blog post....but I truly believe it can/will help those who

do completely read it and follow up with their doctor's on it....

2 Corinthians 1:3, 4

Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;

Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.

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