Acid Suppression Drugs and Antibiotics Given to Infants Strongly Associated with Celiac Disease

Both of my daughters have celiac,   They were diagnosed at age 8 and age 11.   When I was pregnant with both of them, I took zantac amost daily (acid suppression drug).   My doctor said it was fine. Any thoughts on the link to children with celiac for taking acid suppression drugs while pregnant?

There is suspicion that taking acid blockers creates gut dysbiosis which can trigger celiac disease in the person taking the acid blockers. The question then would be does the acid blocker taken by the mother affect the gut of the child in utero. I don't know the answer to that.

But if both your daughters have celiac disease, both parents should be tested and any other children born to the parents should be tested. One large recent study done by the Mayo Clinic showed that 44% of first degree relatives of people with celiac disease proved to have celiac disease themselves when tested, though many or most of them were clueless before testing. To be fair, other studies have shown more like 10% of first degree relatives of celiacs will have it themselves. Your daughters got those genes from somewhere.

Dawn and Trents,

I don't have time to give a lenghty reply tonight.....having already answered another thread topic but I wanted to give you some resources that might help give you some insights.

Eva Untersmayr has done the most work on this subject.  See this is a nice summary article done on her work on this topic.

Entitled "New Study Shows that Antacid Use Leads to More Allergies: Q&A with Eva Untersmayr MD, PhD"

https://asthmaallergieschildren.com/new-study-shows-that-antacid-use-leads-to-more-allergies-qa-with-eva-untersmayr-md-phd/

Here is a more exhaustive research study that will also answer some of your questions and one I will and try to expand/expound another day and time when I have some more time to share their results.....

Read it all in the meantime.....if you have the interest.....it is very informative and exhaustive....

Entitled "Anti-acid medication as a risk factor for food allergy"

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1398-9995.2010.02511.x

With the Holidays coming up.....I am not sure when I will get back to this article but this will point you in the right direction in the meantime.....but for what it is worth they note "Anti-ulcer medications are relevant in human patients"  (and  in children with food allergeis)

Also note: My following is currently not working.....so I won't know immediately when either of you respond...but I will check back in....after the Holidays.

I hope this is helpful but it is not medical advice.

Posterboy,

Dawn and Trents Et Al,

To whom ever might also read this....

Scott combined a two topics into to one that also has some nice resources about the role Low Stomach Acid and/or Acid Reducers like PPIs might have in someone developing food allergies that might also be helpful for you to read.

Again I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

This would explain a lot. I was born overseas to a military couple. I spent the first year of my life with pneumonia. I was on antibiotics the entire time.