Sjogrens Syndrome and Celiac Disease

Collin P et al. (1994) Celiac disease - associated disorders and survival. Gut vol 35 (9):1215 1218.

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Abstract: The associated diseases in 335 celiac patients diagnosed 1980-1990 were compared with age and sex matched control patients with various gastrointestinal symptoms. Endocrine disorders were found in 11.9% of celiac and 4.3% of control patients (p=0.0003). Celiac patients had insulin dependent diabetes mellitus significantly (p=0.0094) more often (5.4%) than control patients (1.5%). Connective tissue diseases were found in 7.2% of celiac and 2.7% of control patients (p=0.011). Sjogrens syndrome occurred in 3.3% of celiac patients and 0.3% of controls (p = 0.0059). Autoimmune thyroid diseases were found in 5.4% and asthma in 3.6% of celiac patients but also in 2.7% and 3.6%, respectively, among control patients. The incidences of malignant disease and the survival rate in celiac patients were compared with those in the Finnish population. Ten celiac patients developed a cancer during the follow up (mean 5.3 years, range 1-12) but none had a lymphoma. The risk of malignant disease did not differ from that in the Finnish population in general. Eleven celiac patients died during the follow up. The five year survival rate of celiac patients did not differ from those in the general population. At least 83% of the celiac patients adhered strictly to the gluten free diet, which may explain the favorable outcome.