Question About Test Results

[formygirl]

I have a doctor's interpretation of these results, but I'm curious about what others with experience would say about these:  

 

gliadin (deaminated) abs

     gliadin, iga        9            standard range <20

     gliadin, igg        48          standard range <20

 

IGA    157    standard range 78-391

 

Transglutiminase Ab, IgA      17   standard range <20

 

Endomysial Ab, IgA  <1:10       standard range DLT10

 

 

Thanks in advance.

 

[nvsmom]

What appears to be your DGP IgG is positive. It is often a good early test for the disease, unlike the EMA Iga which requires a fair bit of damage to register a positive - yours appears negative.

 

I would say it looks like you could be a celiac. DGP tests are pretty specific and sensitive to celiac. Yours is over double the accepted range.

 

Now... many doctors will say you could have a gluten intolerance with just one test positive and hum and hah over actually saying "celiac disease". I'm curious what your doctor said - I feel like I'm being tested!

[powerofpositivethinking]

I feel like I'm looking at my results    I also had only a positive DGP igg, and negative everything else, and I am not igA deficient.  I had an EGD with 8 biopsies, and since they came back normal, my GI diagnosed me with gluten intolerance.  I am also vitamin D and K deficient, and low in potassium.  I still say if it was only gluten intolerance, why is my body creating antibodies against food 

 

interested to hear what your doctor's take on it was!

I have a doctor's interpretation of these results, but I'm curious about what others with experience would say about these:  

 

gliadin (deaminated) abs

     gliadin, iga        9            standard range <20

     gliadin, igg        48          standard range <20

 

IGA    157    standard range 78-391

 

Transglutiminase Ab, IgA      17   standard range <20

 

Endomysial Ab, IgA  <1:10       standard range DLT10

 

 

Thanks in advance.

[formygirl]

These were my results... I was tested after my three year old was diagnosed.  She said the IGg is generally over sensitive and since the total IGa was low (and all other results), we could "ignore" the elevated number.  Hmmm...

[mushroom]

These were my results... I was tested after my three year old was diagnosed.  She said the IGg is generally over sensitive and since the total IGa was low (and all other results), we could "ignore" the elevated number.  Hmmm...

 

Your total IgA is normal, not low.  If it were low (i.e., did not fall within the normal range) then the other IgA tests would not be valid.

 

I would not, however, ignore the positive IgG.  We have posters on the board whose only positive blood test was DGP IgG, and they were positive on biopsy.

[formygirl]

Yeah, this was from my daughter's Gastro doc. I planned on asking my doctor about the results. I am asymptomatic... but I know that doesn't mean I'm negative for Celiac.

This is the quote on the test:

The Gliadin IgG is generally over sensitive. We get it when screening because often patients with celiac disease have a low serum IgA and all of the other markers depend on that level. Since your total serum IgA was normal we can ignore the elevated IgG.

My question: Is there anything else it could indicate besides Celiac?

[mushroom]

Yeah, this was from my daughter's Gastro doc. I planned on asking my doctor about the results. I am asymptomatic... but I know that doesn't mean I'm negative for Celiac.

This is the quote on the test:

The Gliadin IgG is generally over sensitive. We get it when screening because often patients with celiac disease have a low serum IgA and all of the other markers depend on that level. Since your total serum IgA was normal we can ignore the elevated IgG.

My question: Is there anything else it could indicate besides Celiac?

 

The DGP has, I believe, about 99% specificity for celiac disease.  And it is, as the doctor said, a very sensitive test.  It will often pick the disease up in its early stages before there is much intestinal damage. 

[powerofpositivethinking]

so far no one has been able to come up with a reason for a raised DGP score besides celiac.  here's a thread I started regarding it

https://www.celiac.com/forums/topic/100245-other-known-causes-of-high-dgp-igg-besides-celiac/

 

 

My question: Is there anything else it could indicate besides Celiac?

[nvsmom]

I think your doctor's explanation of discounting the DGP IgG test was ... pretty lame. Why would they run it if they are just going to ignore it?  I think some doctors just don't like to label it as celiac because they think the diet is "too hard" which is total hogwash - there are quite a few foods out there that would be harder to get out of our diet if you eat any processed foods at all... like corn!  Eek!

 

The DGP is a really good test. Sensitive is a GOOD thing.... And that was a gastro who said all that, eh? Sheesh.

[formygirl]

Yeah, it was the pediatric gastro who said this.  She had no qualms about doing an endo and diagnosing my daughter, so I don't think she would necessarily be hesitant with me, but who knows.  I don't really know where to go with this.  Since she is not really my doctor, and i'm not under a doctor's care right now, I don't know how to follow up.  I think I will bring it up to her when my daughter has her follow up soon.

[Deaminated Marcus]

Yeah, it was the pediatric gastro who said this.  She had no qualms about doing an endo and diagnosing my daughter, so I don't think she would necessarily be hesitant with me, but who knows.  I don't really know where to go with this.  Since she is not really my doctor, and i'm not under a doctor's care right now, I don't know how to follow up.  I think I will bring it up to her when my daughter has her follow up soon.

 

Your daughter has Celiac !

Doesn't that doctor know that Celiac is hereditary?  

That should be proof enough for the doctor: close family member + high DGP-IgG = do an endoscopy to confirm.

  (+ test the father)   

[formygirl]

father and sister were tested, and she said they were fine.  i saw sisters results... all in normal range, but i didn't see dad's... for all i know it is like mine was.  I have a follow up with her at the end of May for my daughter, so I will talk with her about it at that time.  thanks!