Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Cannabis-like Drugs May Help Bowel Disease

celiachap

By celiachap
in Publications & Publicity

Recommended Posts

celiachap Apprentice
celiachap
Posted

News in Science

Health & Medical News - Cannabis-like drugs may help bowel disease - 15/08/2005

Open Original Shared Link]

Cannabis-like drugs may help bowel disease

Reuters

Monday, 15 August 2005

Derivatives of the active compound in cannabis may one day treat inflammatory bowel diseases, new research suggests.

In preliminary laboratory experiments published in the latest issue of the journal Gastroenterology, UK scientists show that cannabinoids prompt gut cells to repair themselves.

And as gut damage is central to Crohn's disease and ulcerative colitis, this early work may pave the way to using cannabinoid drugs to treat these conditions.

"Cannabinoids, which we make ourselves, as well as synthetic cannabinoids, can promote wound healing in the gut, which is extremely interesting given that inflammatory bowel disease involves damaged gut linings," says lead researcher Dr Karen Wright, of the University of Bath.

Wright and her colleagues found cannabinoid receptors CB1 and CB2 in human colon tissue.

They then used human colon cell lines to investigate the binding of cannabinoid compounds and in wound-healing experiments.

The team found that CB2 was increased in colonic tissue characteristic of inflammatory bowel disease.

And cannabinoids enhanced surface wound closure via mechanisms involving the CB1 receptor.

"The system that responds to cannabis in the brain is present and functioning in the lining of the gut," says Wright.

"There is an increased presence of one component of this system during inflammatory bowel diseases."

Although results are not available yet, she adds, studies of cannabinoids' role in gut disorders are taking place in the UK and a clinical trial is being conducted in Germany.

For more information about gut problems, including symptoms and therapies, see the Gastroenterological Society of Australia's website.

with ABC Science Online

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      130,927
    • Most Online (within 30 mins)
      7,748
    Meg Slack
    Newest Member
    Meg Slack
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Heatherisle
      Blood results

      By Heatherisle · Posted

      Her result for the TTG Ab (IgA) was 19. Lab range 0.0 - 0.7. U/ml. 
    • trents
      Should I be screened for celiac disease?

      By trents · Posted

      TTG would refer to a blood antibody test. Not valid if you are already eating gluten free or mostly so. DQH would refer to a genetic test to see if you possess either or both of the two genes that have been connected most strongly to developing active celiac disease. The genetic test is more of a rule out measure than a diagnostic test as about 40% of the general population have one or both of those genes but only about 1% of the general population develops active celiac disease. If you don't have the genes but gluten causes you issues then the conclusion is NCGS (Non Celiac Gluten Sensitivity) as opposed to celiac disease. So, the genetic testing helps with a differential diagnosis. I don't know about the 2P. 2 Pairs of genes?
    • Scott Adams
      gluten-free Canada finds

      By Scott Adams · Posted

      Tell him to get me a case...just kidding! I wonder why they are not labelled gluten-free here in the USA? They don't have gluten ingredients.
    • Pamela Kay
      Diagnosed gluten allergy but not Celiac

      By Pamela Kay · Posted

      Glad this helped. There are lots of alternative breads out there, so someone has likely made some sort of paleo bread with no grain. And if you bake, experiment with some of the alternative flours to see what you can come up with. If you commit to the gluten-free diet 100%, you may want to do a bit of research on some of the tricker aspects of getting gluten out of your diet, such as cross contamination in the home kitchen (pots and pans, cutting boards, toaster, airborne flour). Don't feel you have to do everything at once, or let this overwhelm you. I've always said that going gluten free is a process, not a moment. The reason I mention this is that, if you think you are gluten-free, but still having symptoms, you may realize that even minute amounts of gluten cause a reaction for a while. Let me know if you have any questions.  Pam
    • Scott Adams
      Should I be screened for celiac disease?

      By Scott Adams · Posted

      The doctor was correct--if you are gluten-free the blood panel for celiac disease will not work, you would need to go on gluten challenge in order to be tested. Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:   This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.    
×
×
  • Create New...