Confusing Test Results

[Trisha123]

Hi,

I had Celiac and ANA testing done by my PCP. Celiac results were negative, but I was eating little gluten at the time of testing. I had undetectable IgA, but they also tested IgG and DPG. I also have low Vit D and slightly high eosinophils. ANA results were positive, 1:640 speckled and 1:640 homogenous, but upon further testing they found lupus and other autoimmune disorders negative. I have an appointment with a GI doctor in a few weeks, but the girl making the appointment couldn't tell me whether or not I need to be eating gluten in preparation, so I am, but don't feel well. I'm thinking of asking my PCP to run the Celiac test again now while I'm eating a lot of gluten so that I don't have to wait for the specialist. Would that be out of line or could the unexplained high titer be due to Celiac?

I don't post on forums and have no idea what I'm doing, so please bear with me.

Thank you for reading!

[cyclinglady]

Welcome!  

I think running the full panel again can be good idea.    But since you have undetectable IgA, consider pushing for the endoscopy.  Some celiacs are simply seronegative.  An endoscopy can rule out not just celiac disease but Other GI autoimmune issues.  In the meantime stay on gluten until that GI appointment.  Be prepared and research!  

I have never had the ANA test and I have three AI issues.  I guess my enlarged thyroid was enough for doctors to catch the start of my AI journey.  Hopefully, another member will answer those questions.  

[Trisha123]

Thank you! And thanks for the reply and info. I'll ask for a blood test and an endoscopy at my appointment.

Eating very little gluten, my DGP IgG was 3.9 U/mL and the range was less than 20 units no antibody detected. If there's an increase would that mean I'm at least sensitive to gluten even if it's still under 20 units and negative? In other words, can I use DGP values in relation to gluten intake as an indicator of gluten intolerance? 

Edited May 8, 2018 by Trisha123
Meant DGP, not DPG

[cyclinglady]

There is no test for a gluten intolerance/sensitivity — only for celiac disease.  If you are gluten intolerant (like lactose intolerant), it is thought to generate symptoms, but no antibodies to self.  You would just have to trial the diet to see how you feel. 

I push for a celiac diagnosis, because it can be difficult to adhere to a lifelong commitment to being gluten free, but it is possible.    A diagnosis can help others in your family to get tested and for you doctor to keep an eye on other Autoimmune illness that may develop or a concurrent illness like osteoporosis.  

[Trisha123]

I thought I sent this reply, but hadn't, sorry...Oh, ok, that makes sense. Best of luck on your AI journey. Thanks for all the info