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Genetics Question

JST1980
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JST1980 Rookie
JST1980
Posted

if genetic testing comes back as “positive for DQ2” with no additional info, what does that mean? It doesn’t specify 2.2 or 2.5. How is DQ2 broken down? If you have only 2.2, do you have half of DQ2? If you have only 2.5, do you have half? Or is 2.5 the “complete” DQ2? So confused. 

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GFinDC Veteran
GFinDC
Posted
(edited)

That gene indicates your are part werewolf!  :(

Eeek!   :) 

Sorry, I don't know the exact answer to your question.  I do know that having the genes for celiac disease does not mean you will automatically get celiac disease.  About 28% of people in the USA have one of the genes related to celiac disease, but only about a 1% actually get celiac disease.  There are theories about why that is so, but no definite conclusions.   It could be the genes are activated by a stimulus like a virus, or an emotional stress ( I call BS on that) or pissing off your doctor somehow.  But the fact is it remains that some people with the gene get celiac and others don't.  I guess some people get more gene fertilizer than others?

If you are concerned  about having celiac disease, stay on gluten and get tested.  The tests aren't accurate after you quit eating gluten.  The test (blood antibodies first) measure the immune response to gliaden, a protein in wheat gluten.  Then later usually, an endoscopy takes biopsy samples to review for possible celiac type damage.

It's much more pleasant to stay on gluten and get the testing done than stop eating gluten and have to start eating it again for testing.  If you have celiac that is; IMHO.

Welcome to the forum, we are glad to help with any questions!  :)  Just don't make them too hard!  :)   There is a Newbie 101 thread in the Coping With section with some answers.

Edited by GFinDC
National emoji day :) :(
JST1980 Rookie
JST1980
Posted
  • Author

Thank you so much! I’m asking for a different reason. One of my children has celiac and we have all had a celiac panel done and are awaiting genetic testing results. My other child got back a result of “dq2” and I was just curious because in my research, I see that dq2.2 alone is way less commonly linked to celiac. DQ2.2 is what I believe I have as well. So I’m wondering when a lab says “dq2” if it involves 2.2, 2.5 or both? Thanks for the info! 

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