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Waiting for possible diagnosis


Lisacnj3

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Lisacnj3 Rookie

Hello, I am currently waiting for my 2nd appointment with my Rhumatologist. After 1st appointment she ran a battery of blood test & x-rays of my whole body. My deamidated gliadin IGG is 43, my tTG IgA is 64 and my Immunoglobulin A is under 5. I was recently diagnosed with Hashimotos with thyroiditis. I’m expecting a pre diagnosis of Celiac Disease and hopefully a biopsy for final diagnosis. Sadly I’m eating all the gluten I want because I know I’ll have to be giving it up


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Scott Adams Grand Master

Welcome to the forum!

Could you please share the reference ranges for each of those tests? This would be the cut off level for positive, and each can vary depending on the lab used.

With this extra information we might be able to comment on your results.

trents Grand Master

Continue to eat a significant amount of gluten until all tests are complete or the testing may be invalid.

Lisacnj3 Rookie
5 hours ago, Scott Adams said:

Welcome to the forum!

Could you please share the reference ranges for each of those tests? This would be the cut off level for positive, and each can vary depending on the lab used.

With this extra information we might be able to comment on your results.

The deamidated gliadin IGG range is 0-19 so my 43 is a moderate to strong positive, the TTG IGG range is 0-5 so my 64 is high positive. The reference range for immunoglobulin A is 87-352 so my <5 is nonexistent. My thyroid peroxidase (tpo) was 109 and the range is 0-34. I also had 2 strong positive antibodies for the Lupus screening. I’ve been having symptoms of chronic fatigue, muscle pain, joint pain, hair loss, insomnia and severe heat intolerance for a few years now

5 hours ago, trents said:

Continue to eat a significant amount of gluten until all tests are complete or the testing may be invalid.

Thank you, I plan on keeping my gluten intake high for now

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    • trents
      If this applies geographically, in the U.K., physicians will often declare a diagnosis of celiac disease based on the TTG-IGA antibody blood test alone if the score is 10x normal or greater, which your score is. There is very little chance the endoscopy/biopsy will contradict the antibody blood test. 
    • JoJo0611
      TTG IgA reference range 0.0 to 14.9 KU/L
    • trents
      What was the reference range for that test? Each lab uses different reference ranges so a raw score like that makes it difficult to comment on. But it looks like a rather large number.
    • JoJo0611
      I have had the tTG-IgA blood test my result are >250.0  I am waiting for the appointment with the gastroenterologist for endoscopy and biopsies.    what are the chances it’s not coeliacs.  waiting and not knowing is so hard. Especially the eating of gluten knowing it may be causing you more harm and coping with the symptoms. 
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      @sleuth, Has your son been checked for nutritional deficiencies?  All of those symptoms can be caused by malnutrition.  I had severe malnutrition that went unrecognized by my doctors.  Intense fatigue, brain fog, depression, anxiety, and gastrointestinal distress are symptoms of deficiencies in the eight essential B vitamins, especially Thiamine B1, which becomes low first because the demand is higher when we're sick.     Celiac Disease causes inflammation and damage of the intestinal lining which inhibits absorption of essential nutrients.  Checking for nutritional deficiencies is part of proper follow up care for people with celiac disease.   Is your son taking any vitamin supplements?  Most supplements contain thiamine mononitrate which in not readily absorbed and utilized by the body.  Benfotiamine is a form of thiamine that is shown to promote intestinal healing.  Benfotiamine is available over the counter.  Benfotiamine is safe and nontoxic.   Is your son eating processed gluten-free foods?  Gluten-free processed foods are not required to be enriched with vitamins like their gluten containing counterparts.   Is your son following a low histamine diet?  Histamine is released as part of the immune response to gluten and other foods high in histamine.  High levels of histamine in the brain can cause anxiety, insomnia, and depression.  The body needs the B vitamins to make the enzyme Diamine Oxidase (DAO) to break down and clear histamine.  DAO supplements are available over the counter.  Vitamin C helps clear histamine as well.  Some people find over the counter antihistamines helpful as well, but they're not for long term use.   Nicotine has antihistamine-like properties, but can also irritate the gut.  Tobacco, from which nicotine is derived, is a nightshade (like tomatoes, potatoes, peppers and eggplant).  Nightshades contain alkaloids which affect gastrointestinal permeability, causing leaky gut syndrome.  Nicotine can cause gastrointestinal irritation and alter for the worse the microbiome. Safer alternatives to Nicotine that have antihistamine properties include Lemon Balm (Sweet Melissa),  Passion Flower, Chamomile, and Bilberry.  They can be taken as supplements, extracts, or tea.  These will help with the anxiety, insomnia and depression in a much safer way. Oolong tea is also helpful.  Oolong tea contains the amino acid L-Theanine which helps the digestive tract heal.  (L -Theanine supplements are available over the counter, if not a tea drinker.)  Tryptophan, a form of Niacin B3, also helps calm digestive symptoms.  Another amino acid, L-Lysine, can help with anxiety and depression.  I've used these for years without problems.   What ways to cope have you tried in the past?
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