cytokines Cytokine (aka Interleukin) release and gastrointestinal symptoms after gluten challenge in celiac disease

[Posterboy]

To All,

A few years ago Celiac.com featured an article on Cytokines (aka different Interleukins) that are produced in response to a gluten challenge and it got me thinking?

Here is the article as summarized by Jefferson Adams if you would like to scan the summary...

Here is the length to the full study if somebody wants to read through/scan and explain to me and other on the Celiac.com forum.

https://www.science.org/doi/10.1126/sciadv.aaw7756

A recent discussion lead me do some more research on this topic?

Could poor nutrition be a trigger for Cytokine reslease and I found YES it could be!

Here is the research that I wanted to lead with.....their is other research that can be included but this is just to get the ball rolling/started you might say...

Here is looking at you Blue-Sky @Blue-Sky

30+ years old and the medical community has forgotten how Cytokine/Interlukin production is triggerd/controlled by poor nutrition!

See this research on Zinc

Entitled "Role of zinc in interleukin 2 (IL-2)-mediated T-cell activation"

https://pubmed.ncbi.nlm.nih.gov/2345864/#:~:text=In a serum-free culture containing no zinc%2C zinc,was completely inhibited by anti-IL-2 receptor (CD25) antibodies.

This one is also worth your time explains B-Vitamins role in Cytokine production in the body as sign of Inflammation.

Entitled "The effects of vitamin B on the immune/cytokine network and their involvement in depression"

https://www.maturitas.org/article/S0378-5122(16)30299-7/fulltext

What do other's think......which came first (the poor nutrition) or the inflammation (IE triggering) the Immune response?

I wish us all good health soon!

STRESS Kills us.....but it MAIMS us first!

I hope this is helpful but it is not  medical advice.

Also in tribute to Blue-Sky it is worth noting Blue-Sky's great blog post on a Zinc deficiency as a possible trigger for IBS......which is the best article on Celiac.com IMO on the topic of Zinc!!! as it relates to GI problems like IBS etc.

Posterboy by the grace of God,

[Blue-Sky]

On 10/7/2022 at 6:56 PM, Posterboy said:

Entitled "Role of zinc in interleukin 2 (IL-2)-mediated T-cell activation"

https://pubmed.ncbi.nlm.nih.gov/2345864/#:~:text=In a serum-free culture containing no zinc%2C zinc,was completely inhibited by anti-IL-2 receptor (CD25) antibodies.

In that link, zinc creates a proinflammatory immune reaction.

Zinc supplementation still is beneficial in some models of IBS and in Crohn's disease. Zinc supplementation may also be helpful for Celiac recover but I don't know if that has been demonstrated. The immune system repairs a damaged digestive tract. 

https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.202000562RR

Other things that seem to have a paradoxical effect of boosting the immune system and helping with ibs include:

Lion's main mushrooms (I did another blog post including that)

probiotics.

Fiber

Flavonoids

NSAID lower prostaglandin 2, via cox-2 I think going by memory.

A Hawaiian diet high in native fruits also sounds healthy, but also boosts the immune system.

Online there is information that flavonoids and other things that boost prostaglandin 2 (including niacin) help with stomach ulcers causes by NSAID.

Acacia fiber boosts the immune system I think, and increase bacteria content in the upper digestive track, and boost nitric oxide synthesis, but this also desensitized the immune system. Nitric oxide production is boosted, but sensitivity to nitric oxide is lowered. Signs of inflammation are lowered in other organs in the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435782/

High dosages of thiamine boost cell metabolism and activate nr-f2. Niacin, fiber, food metabolites and probiotics also act as nr-f2 activators. Something like 70% of ROS are created by energy production within the mitochondria of cells. ROS boost Nr-f2. Nr-f2 decreases cells energy expenditure and it acts as HDAC inhibitor. There is a check on cell growth and activating it seems healthy for some people at least.

I have heard it is also common for the body to make antibodies against garlic and an enzyme in papaya. Capsaicin can make skin cancer more common in mice by increasing epidermal growth factor. Garlic lowers sensitivity by activating nr-f2 and reducing sensitivity to epidermal growth factor.

Another thing that seems to have a paradoxical effect is flavonoids. Some flavonoids boost th1 and th17 but are still beneficial for th1 and th17 dominate autoimmune diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859886/

 

 

[Scott Adams]

The zinc connection to inflammation interesting, and there is definitely a connection between poor nutrition and Cytokine production.