Cancer risk and nicotinamide riboside (NR) - a form of vitamin B3

[Scott Adams]

Since we're discussing vitamin supplements here so much because celiacs often need them, I thought this was interesting:

"Scientists discovered that high levels of NR could not only increase someone’s risk of developing triple-negative breast cancer, but also could cause the cancer to metastasize or spread to the brain."

https://scitechdaily.com/warning-popular-vitamin-supplement-causes-cancer-risk-and-brain-metastasis/

 

[Posterboy]

Scott,

My nephew actually showed/shared with me this research recently.

Here is a couple links that will explaing the difference between Niaicinamide and Niacinamide Riboside aka NR.

Form matters......and Niacinamide Riboside is not commonly available because of it's high price.....IN FACT it can't be found on the Vitamin Shoppe's website to even order......they are conflating one supplement (form) with the other....and transferring the potentinally harmful altered form to the natural Vitamin healing form of Vitamin B3.....because it does indeed unaturally promote cell NAD+ levels....which the cancer cells use to grow.....Niacin and/or Niacinamide by themselves do not do that....

https://www.thorne.com/take-5-daily/article/meet-the-vitamin-b3-family-nr-nmn-niacin-explained

See their chart (I couldn't copy it over)......Niacinamide does not promote NAD+ the substance that promotes the cancer link the way the Niacinamide Riboside aka NR form does.

See also this link

https://htfd6.org/is-niacinamide-the-same-as-nicotinamide-riboside/

That explains the difference between the two forms.....quoting

"What is the difference between niacinamide and nicotinamide riboside?

The way that your body converts dietary vitamin B into NAD makes all the difference. Nicotinamide, also known as niacinamide, is an amide of nicotinic acid, which is commonly known as niacin. Nicotinamide riboside (NR), on the other hand, is a chemically altered form of nicotinamide that has unique attributes." that promotes the cancer link connection found in the latest research.....

The non NAD+ promoting form of Niacin and/or Niacinamide alone can actually help promote Cancer healing!

See this recent research that bears this out....

Entitled "Study: Niacin may help immune system battle a deadly brain tumor"

quoting from this article where Niacin actually tripled survival rates in brain tumors...

"The results published in Science Translational Medicine found the lifespan of mice with glioblastoma that received combination therapy tripled, increasing to 150 days from 40 days."

IN FACT after studying over 1,000 plus subtances they found Vitamin B3 promoted cancer survival better than any other substance screened.

Quoting again...

"We were able to help immune cells do what they're supposed to do, attack and kill cancer cells," says Dr. Susobhan Sarkar, Ph.D., first author on the study. "We screened 1,040 compounds and found niacin had the properties needed to activate immune cells, specifically myeloid cells, and inhibit the growth of brain tumor initiating stem cells."

The NAD+ stimulating affects of NR is the problem and not the natural Niacin or Niacianmide form....

IN FACT the Niacin therapy alone was able to extend life of the most dangerous brain cancers!

quoting again...

"In the study, the researchers found that niacin therapy alone extended survival and that the combination therapy with temozolomide (a chemotherapy drug commonly used against glioblastoma) markedly prolonged survival by stimulating and re-educating immune cells to stop helping the cancer and instead, destroy it."

Wrong form......wrong results.....in the right (Natural) forms you have wonderful, healthy, healing results!

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,

[knitty kitty]

I believe a patent-able form of a niacin precursor is trying to be manufactured.  It is not possible to patent a naturally occurring substance like vitamins, but it's possible to patent a synthetic form or in a delivery system form.

NR is naturally present in foods like dairy.

 

"Synthesis of Mixed Dinucleotides by Mechanochemistry"

https://www.mdpi.com/1420-3049/27/10/3229

 

And....

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183138/

And...

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/

 

And...

B-vitamins and NAD metabolism, or when vitamin B3's bioavailability is not enough

https://gtr.ukri.org/projects?ref=BB%2FN001842%2F1

 

Niacin and thiamine work together.  While NR may stimulate cancer if left floating around, with Thiamine to further process NR to a less active state, and with thiamine's anticancer effects...  just another example of how vitamins all work together.

NR by itself is not a good marketing risk.

[Posterboy]

Scott and Knitty Kitty,

This backs up Knitty Kitty’s assertion about the attempt to patent NAD+ as a drug……taking it off the available supplement list…

It is a interesting read…..and shows how Vitamins and supplements compete with “Patentable Drugs” in the marketplace….

https://www.lifespan.io/news/fda-purges-nmn-from-the-list-of-supplements/

Entitled  "FDA Purges NMN From the List of Supplements: The rationale is that it is being investigated as a drug."

And probably why Nicotinamide Riboside (NR) is not widely available as a supplement anymore.....because it has been declared as a possible "Drug Candidate"......I always wondered why I couldn't find it anymore.....and this article explains why?

Note: both the NR and NMN forms are precursors of NAD+ and open for "Patenting" as drugs but Niaciamide or Niacin is not because they are actually different forms of Vitamin B3 itself aka Nicotinic Acid in its flushing form or Niacinamide in the naturally flush free form!.....so they invented a "patentable" drug form called Niaspan which had "Side Effects" not caused by the "Natural Form" of Niacin......and too this day the Naturual form of Niacin is confused for the Synthetic from which cause side efffects...

They have KNOWN about this affect for 10 years now.....and drug companies are still trying to go around the natural healthy form of Niacin.......and they almost always  have to deal with the side effects from not using the natural, healthy forms of Vitamin B3.

Entitled "New study cautions use of drugs to block 'niacin flush'"

https://medicalxpress.com/news/2012-04-cautions-drugs-block-niacin-flush.html

Interestingly Vitamins can’t be patented as Knitty Kitty noted but their precursors can etc…. NMN and NR are precursor for NAD+ etc….

Lucky natural NAD+ precursor are available in foods and no supplements are needed to boost NAD+ levels….

Quoting from the article…

“NAD+ levels can be boosted via its precursors, which include nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). NMN-containing supplements have been gaining popularity in the longevity community, even though not everyone agrees on their effectiveness or safety. NMN naturally occurs in foods such as edamame, broccoli, cabbage, cucumber, and avocado.”

I still remember this same kind of  "Brough Ha Ha" over Red Rice yeast back in the day.....it too was asked to be banned as a supplement because it had a patentable natural form of Statins.....

And the drug companies didn't want the competiton!

I hope this is helpful.

Posterboy,

[RMJ]

53 minutes ago, Posterboy said:

Scott and Knitty Kitty,

This backs up Knitty Kitty’s assertion about the attempt to patent NAD+ as a drug……taking it off the available supplement list…

It is a interesting read…..and shows how Vitamins and supplements compete with “Patentable Drugs” in the marketplace….

https://www.lifespan.io/news/fda-purges-nmn-from-the-list-of-supplements/

Entitled  "FDA Purges NMN From the List of Supplements: The rationale is that it is being investigated as a drug."

And probably why Nicotinamide Riboside (NR) is not widely available as a supplement anymore.....because it has been declared as a possible "Drug Candidate"......I always wondered why I couldn't find it anymore.....and this article explains why?

Note: both the NR and NMN forms are precursors of NAD+ and open for "Patenting" as drugs but Niaciamide or Niacin is not because they are actually different forms of Vitamin B3 itself aka Nicotinic Acid in its flushing form or Niacinamide in the naturally flush free form!.....so they invented a "patentable" drug form called Niaspan which had "Side Effects" not caused by the "Natural Form" of Niacin......and too this day the Naturual form of Niacin is confused for the Synthetic from which cause side efffects...

They have KNOWN about this affect for 10 years now.....and drug companies are still trying to go around the natural healthy form of Niacin.......and they almost always  have to deal with the side effects from not using the natural, healthy forms of Vitamin B3.

Entitled "New study cautions use of drugs to block 'niacin flush'"

https://medicalxpress.com/news/2012-04-cautions-drugs-block-niacin-flush.html

Interestingly Vitamins can’t be patented as Knitty Kitty noted but their precursors can etc…. NMN and NR are precursor for NAD+ etc….

Lucky natural NAD+ precursor are available in foods and no supplements are needed to boost NAD+ levels….

Quoting from the article…

“NAD+ levels can be boosted via its precursors, which include nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). NMN-containing supplements have been gaining popularity in the longevity community, even though not everyone agrees on their effectiveness or safety. NMN naturally occurs in foods such as edamame, broccoli, cabbage, cucumber, and avocado.”

I still remember this same kind of  "Brough Ha Ha" over Red Rice yeast back in the day.....it too was asked to be banned as a supplement because it had a patentable natural form of Statins.....

And the drug companies didn't want the competiton!

I hope this is helpful.

Posterboy,

I always like to go to the source of information.  Here is a link to the FDA letter indicating that NMN cannot be defined as a dietary supplement in the US. 

FDA letter

[Scott Adams]

The form I've been taking is inositol hexanicotinate, so hopefully it's not prone to this issue.

[Posterboy]

Scott Et Al,

I alluded to this earlier......when drug companies started blocking the "natural action" of Niacin aka Nicotinic Acid to flush us.....it looses/limits some of the benefits people seek to get from taking Niacin in the first place.

Here is the summary of the findings...

https://www.nbcnews.com/health/health-news/niacin-doesnt-stop-heart-attacks-major-study-finds-flna1C9459707

It was called the "Thrive Study" and before it Niacin as the Patented Slow Release "Niaspan" form failed to lower heart risk......and since that time Niacin has been looked down on in the medical community.

It is because it blocks the natural healthy flushing of Niacin.....if you want the benefit of taking Niacin.....you will have to take the Nicotinic Acid form......and titrate it up....or take the Naturally flush free form of Niacinamide....

Here is a great overview artcle of why you want to "Invite the Flush" of Niacin.

https://life-enhancement.com/pages/why-the-niacin-flush-may-be-surprisingly-beneficial-to-your-health

This article explains how to tritrate up your levels of Naicin so the flushing is not too intense.....so you don't stop it before it does you any good....

http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Once you know how healthy the flush is too you......then it is an easy thing to tolerate....and with each succeeding flush.......the flush is a little less intense each time.....until it just goes away naturally!

It happens like clockwork in higher does of Nicotonic Acid say 100mg to 200 mg etc... after 30 minutes you start the flush and after an hour (or so) depending on the original dosage amount.....the flush subsides....

IF it is not Niacinamide or the flushing kind of Niacin......you are not doing it right!

Essentially, NO Flush equals NO Benefit.....or at least the kind you are looking for by taking Niacin aka Vitamin B3 in the first place.

Note: Niacinamide because it does not flush you will not help your Cholesterol levels but the flushing Nicotinic Acid (NA) form will and that is why it helps your elevated Cholesterol levels......and is also, in part, why Non-Flushing Niacin does not help the way the naturally flushing kind will/does!

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,

P.S. Here is the full STRIVE Study if someone want to read it.....and note the effect of "NO Heart" Benefit was the from the Flush Free Form.....the exact same kind that you are taking now....

https://www.nejm.org/doi/full/10.1056/NEJMoa1300955