Normal Ttg-IgA/ Grossly Elevated Ttg-IgG

[Spacepanther]

Hello~

I was diagnosed recently and I have been gluten-free since. Other than gluten exposure, what could cause Ttg-IgG to continue to be elevated even when Ttg-IgA is nearly normal?

Specifically, my blood work from August 10 reported both Ttg- IgA and Ttg-IgG at >250 u/L so both were very high - 0 - 14.6 u/L is the normal range. 

My blood work from November 28 reported my Ttg-IgA at 15.4 u/L. Where 0 - 14.6 u/L is the normal range, my IgA score was nearly normal. However, my Ttg-IgG was unchanged at > 250 u/L which is grossly elevated. 

Does anyone have experience with or knowledge about non-IgA deficient Ttg-IgG elevations? My symptoms have continued intermittently. While gluten exposure could be a result, why wouldn't IgA be elevated similarly? Are there other concerns related to Ttg-IgG that could cause similar elevations?

[RMJ]

You don’t really know if your Ttg-IgG is unchanged or not.  Greater than 250 could be 25,000 or 251.  It could have decreased from 25,000 to 251. 

Good job on getting the Ttg-IgA down to near normal!  It is not at all unusual for results to still be high after only four months of a gluten free diet. I would be that the IgG has come down but is still above the range of quantitation so you can’t see it.

[Scott Adams]

It seems like you're on the right path, as your levels seem to be dropping rapidly. 

If you eat at restaurants or outside your home it's possible you're getting some contamination. It's always a good idea to reexamine your diet. 

This article has some detailed information on how to be 100% gluten-free, so it may be helpful (be sure to also read the comments section.):