Understanding Genetic Testing: half DQ2

[NikkiRose96]

I’m trying to read my genetic report to better understand. It looks like my report came back with half a gene but my doctor stated I was negative for celiac? Has anyone had experience with a report similar to this? Is it actually negative? Unfortunately I have already been living a gluten free lifestyle so the other testing isn’t possible unless I reintroduced gluten so trying to determine the likelihood genetically first. 
 

My report came back saying: 

The patient is positive for

DQA1*05, one half of the DQ2 Heterodimer.

[knitty kitty]

Welcome to the forum, @NikkiRose96!

While only having one allele for Celiac may put you in a lower risk group for developing celiac disease, it also may put you at higher risk for ulcerative colitis.

Not diagnosing.  

 

HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701736/

[Scott Adams]

The number of genes associated with celiac disease is more than two, but there are two main genes that are commonly tested for celiac disease susceptibility. These genes are HLA-DQ2 and HLA-DQ8.

• HLA-DQ2: The majority of individuals with celiac disease (about 90-95%) carry the HLA-DQ2 gene.
• HLA-DQ8: Around 5-10% of individuals with celiac disease have the HLA-DQ8 gene.
• Other Genes: While HLA-DQ2 and HLA-DQ8 are the primary genes associated with celiac disease, having these genes doesn't guarantee that someone will develop celiac disease. Additionally, a small percentage of individuals with celiac disease don't have either of these genes. This suggests that other genetic factors may also play a role, though they are less common.

This article has more information about the genes associated with celiac disease: