Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Post Celiac Diagnosis - Follow Up Labs

MegS123
 Share

Recommended Posts

MegS123 Newbie
MegS123
Posted

Hi all! 
 

I was diagnosed with celiac disease in Oct of 2023 through blood work & then an endoscopy. At the time of diagnosis, my Endomysial Antibody IgA came back positive abnormal,  t-Transglutaminase (tTG) IgA was at 90 (negative 0-3, weak positive 4 - 10, positive >10) & Immunoglobulin A serum was 385 (normal range 87-352). 
 

I had a follow up set of labs done ~7 months into a gluten-free diet and my Endomysial Antibody IgA came back negative, my t-Transglutaminase (tTG) IgA was at 40 (> 15 = antibody detected) & Immunoglobulin A was 378 (normal range 47-310). 
 

I just had a second set of follow up labs done on Monday (~11 months into gluten-free diet) and received the below results. 
- TISSUE TRANSGLUTAMINASE AB, IGA = 16.5 (> 15 = antibody detected)

- IMMUNOGLOBULIN A = 366 (47-310 normal range) 

- TISSUE TRANSGLUTAMINASE AB, IGG = <1 (<15 no antibody detected) 

I haven’t been able to speak with my doctor yet so was wondering what others peoples thoughts / experiences have been with the below. 
 

1. My immunoglobulin A serum results are decreasing but in comparison to the other markers, it seems like it’s been taking longer to drop. Is this normal? 
 

2. The labs on Monday were the first time I’ve been tested for TISSUE TRANSGLUTAMINASE AB, IGG, which obviously came back negative. Has anyone else tested negative for this but still confirmed celiac? Maybe wishful thinking but wondering if there’s any way this could indicate I don’t have celiac 🙃???

 

Thanks!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted

Welcome to the forum, @MegS123!

First, the immunoglobulin A is not a celiac diagnostic test per se. This is a measure of total IGA and if it is abnormally low, aka, "IGA deficiency", it will suppress individual celiac antibody test values such as the TTG-IGA and which can potentially result in false negatives. I do not know that there are any particular health issues associated with elevated immunoglobulin A. The important point from this score in the immediate context is that you are not IGA deficient so your individual IGA celiac antibody test scores should be reliable.

Second, IGG antibody tests are second tier celiac antibody diagnostic tests which can be helpful in catching those who actually do have celiac disease but who respond atypically to the IGA antibody tests which are considered first tier. But to your question, it is typical to not produce positive scores for all the various kinds of celiac antibody tests. If this were not so, why would we need more than one kind of test?

The big picture is that it seems you are being successful in eating gluten free.

Here is a primer for understanding the various kinds of antibody tests that can be used to detect celiac disease: 

 

MegS123 Newbie
MegS123
Posted
  • Author

Thank you @trents!! This is helpful!

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. DebD5
      - DebD5 replied to Bebygirl01's topic in Related Issues & Disorders
      26

      How many people here are aware that there are 9 types of gluten that Celiacs should be aware of?

      I would like to say you saved me. I’ve been so sick the last few years, celiac since 1997. And reading your post about the other glutens/grains that can be sensitive to celiacs, is the only thing that has ever helped me. Since going off a carbohydrates/grains, even gluten-free ones, My chronic pain is 85% better. I’m actually losing weight which, that’s a...
    2. DebD5
      - DebD5 replied to ohmichael's topic in Super Sensitive People
      12

      Curious if I should quit my job

      I 100% believe if you were sticking gluten items, especially flour, and breathed it in you could be glutened. I’m a celiac for almost 30 years. For the first ten years as a celiac I’d help my polish family make pierogis at Christmas time. I would only cook them at the stove and I didn’t touch anything with my hands using spoons. But the flour is in the a...
    3. DebD5
      - DebD5 replied to annirosex's topic in Related Issues & Disorders
      2

      Dealing with celiac and menstrual cycle

      Have you had your thyroid checked? I was diagnosed at 24 with celiac. Lost my period permanently at 32. Found out six months after I lost my period that I had 1 ovary with 1 follicle. I had a child already but wanted more. Ended up having two more children with one ovary and one follicle. But my doctors theories are if I would have gotten my thyroid checked...
    4. DebD5
      - DebD5 replied to Katiexox's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Advice please

      This. Scott said it beautifully. Document and start a trial gluten-free diet. I can also recommend an inflammation dietitian I saw last summer if interested. She’s the only one who helped me on a path to healing through an elimination diet. Which is tricky with your little one. But I completely trust her, she’s very expensive though. I figured out I’m se...
    5. DebD5
      - DebD5 replied to StevieP.'s topic in Related Issues & Disorders
      5

      Fodzyme

      I so appreciate you talking about this. Honestly I’m so sick the most part of the last 15 years, I’m going to cross reference your list with my own. Celiac since 24 yrs old diagnosed in 1997. I just saw a specific celiac GI specialist at the celiac disease center in Chicago and when I told her all the food reactions I was having she said she believed me ...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      129,638
    • Most Online (within 30 mins)
      7,748
    Alice 6
    Newest Member
    Alice 6
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.2k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • DebD5
      How many people here are aware that there are 9 types of gluten that Celiacs should be aware of?

      By DebD5 · Posted

      I would like to say you saved me. I’ve been so sick the last few years, celiac since 1997. And reading your post about the other glutens/grains that can be sensitive to celiacs, is the only thing that has ever helped me. Since going off a carbohydrates/grains, even gluten-free ones, My chronic pain is  85% better. I’m actually losing weight which, that’s a long story but was impossible. I definitely am like you. Thank you so very much for posting. For some of celiacs I do believe this is the magic key. 
    • DebD5
      Curious if I should quit my job

      By DebD5 · Posted

      I 100% believe if you were sticking gluten items, especially flour, and breathed it in you could be glutened. I’m a celiac for almost 30 years. For the first ten years as a celiac I’d help my polish family make pierogis at Christmas time. I would only cook them at the stove and I didn’t touch anything with my hands using spoons. But the flour is in the air. And I’d get violently ill for 1-2 weeks after the last few years I did it. Wearing a back is a great suggestion and washing your clothes and showering when you get home. Good luck. And I’m so sorry your parents are emotionally supporting you. 
    • DebD5
      Dealing with celiac and menstrual cycle

      By DebD5 · Posted

      Have you had your thyroid checked? I was diagnosed at 24 with celiac. Lost my period permanently at 32. Found out six months after I lost my period that I had 1 ovary with 1 follicle. I had a child already but wanted more. Ended up having two more children with one ovary and one follicle. But my doctors theories are if I would have gotten my thyroid checked sooner and fixed through medication, maybe things would look different. Who knows. I only share my experience so you question your doctors and advocate. Always see an endocrinologist for thyroid care fyi. Actually always see the specific Dr for your specific ailments. I’d also consider seeing a gynecologist that specializes in female hormones/menopausal symptoms. Early ovarian failure happens in celiacs so I read  on the celiac disease center in Chicago website. 
    • DebD5
      Advice please

      By DebD5 · Posted

      This. Scott said it beautifully. Document and start a trial gluten-free diet. I can also recommend an inflammation dietitian I saw last summer if interested. She’s the only one who helped me on a path to healing through an elimination diet. Which is tricky with your little one. But I completely trust her, she’s very expensive though. I figured out I’m sensitive to so many things and follow a gluten-free diet religiously. Just had an upper and lower endoscopy/colonoscopy and zero signs of celiac disease so they said. I’m a celiac since 1997. But my 33 yr old daughter is very gluten intolerant since 20 yrs old. 
    • DebD5
      Fodzyme

      By DebD5 · Posted

      I so appreciate you talking about this. Honestly I’m so sick the most part of the last 15 years, I’m going to cross reference your list with my own. Celiac since 24 yrs old diagnosed in 1997. I just saw a specific celiac GI specialist at the celiac disease center in Chicago and when I told her all the food reactions I was having she said she believed me but there was no clinical evidence to support my reactions(I felt so unseen, she recommended I see a gut psychologist, what the heck). I react with severe body aches to bloating and dizziness to exhaustion:  most lectins except berries and low lectin veg, no eggs, no nightshade veg, no dairy, all carbohydrates including no gluten-free carbs or grains, though a little coconut flour seems ok now, need to test other non grains, certain alcohols that say gluten-free but looking into their process further I get horribly sick if distilled through a gluten grain example Costco vodka….. Because I had an upper and lower GI in 1997(I was 24 and 84#s) and my GI doc came back with celiac disease, this new doc suggested I may not be a celiac. Is running some blood test. Omg. I can’t even. I’m so beyond frustrated. 
×
×
  • Create New...