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Blood results

Heatherisle
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Heatherisle Newbie
Heatherisle
Posted

Hi 

New to this so bear with me!!! My daughter was told a few years ago she probably had IBS but been feeling generally worse lately Recent IgA TTG Ab blood test indicative of coeliac at 19 U/ml but Endomysial IgA Abs negative. Awaiting appointment for biopsy , so was wondering if anyone else has had these differing results. Thank you

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trents Grand Master
trents
Posted
(edited)

Welcome to the forum, @Heatherisle!

Yes, not uncommon for multiple celiac antibody tests to not agree. The Endomysial IGA was the first antibody test developed to detect celiac disease. It is expensive to run and has largely been replaced by the tTG-IGA. But some physicians, particularly those who have been in practice for awhile, still order the EMA. It's a good test. Was there a "total IGA" test run to check for IGA deficiency?

 

Edited by trents
Heatherisle Newbie
Heatherisle
Posted
  • Author

Hi

Thanks for answering so quickly. Not sure about any other blood tests, all I have is a copy of what my daughter sent to me. Hopefully she’ll get the biopsy soon cos she’s really anxious about the whole thing, but she tends to have a lot of anxiety anyway and has done for a long time

RMJ Mentor
RMJ
Posted

Be sure to have her continue eating gluten before the biopsy. Reducing gluten now could lead to healing and false negative results.

Heatherisle Newbie
Heatherisle
Posted
  • Author

She’s eating mostly gluten as far as I know. Think her GP is trying to get her seen fairly quickly

Russ H Community Regular
Russ H
Posted
15 hours ago, Heatherisle said:

Hi 

New to this so bear with me!!! My daughter was told a few years ago she probably had IBS but been feeling generally worse lately Recent IgA TTG Ab blood test indicative of coeliac at 19 U/ml but Endomysial IgA Abs negative. Awaiting appointment for biopsy , so was wondering if anyone else has had these differing results. Thank you

Do you know what the lab's standard range is for the IgA tTG2 result? The Endomysial IgA basically tests for the same antibodies as IgA tTG2 but it uses an older, less sensitive method and the result is positive/negative rather than quantitative. Hence, it is possible to show raised IgA tTG2 antibodies without getting a positive test for Endomysial IgA antibodies.

Heatherisle Newbie
Heatherisle
Posted
  • Author

Her result for the TTG Ab (IgA) was 19. Lab range 0.0 - 0.7. U/ml. 

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Russ H Community Regular
Russ H
Posted
On 8/21/2025 at 11:40 AM, Heatherisle said:

Her result for the TTG Ab (IgA) was 19. Lab range 0.0 - 0.7. U/ml. 

That is more than 10x the standard range, so a strong positive. In the UK for children and adults under the age of 55, at least 10x the standard range is sufficient to be diagnosed without having an endoscopy. The NICE guidelines are are different for children in that a referral to a gastroenterologist is also recommended for diagnosis.

https://www.coeliac.org.uk/healthcare-professionals/diagnosis/how-to-test/

https://www.coeliac.org.uk/healthcare-professionals/diagnosis/diagnosis-in-children/

 

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      That is more than 10x the standard range, so a strong positive. In the UK for children and adults under the age of 55, at least 10x the standard range is sufficient to be diagnosed without having an endoscopy. The NICE guidelines are are different for children in that a referral to a gastroenterologist is also recommended for diagnosis. https://www.coeliac.org.uk/healthcare-professionals/diagnosis/how-to-test/ https://www.coeliac.org.uk/healthcare-professionals/diagnosis/diagnosis-in-children/  
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