Biospy Results

[Guest DONNAJ]

Hi

Haven't posted for a long time sorry.

My daughter has had ongoing health issues since birth (reflux and milk protein allergy) she is now 2 years old.

We tried wheat free for 4 months different child (in a great way) no more sleep issues, uncontrollable behaviour,tearing at clothes, screaming for hours on end, horrible poos etc etc.

We reintroduced wheat nearly 3 months ago and have yesterday had a gastroscopy done, can anyone tell me what "initial findings abnormal cells"means???

She has double dose of the celiac gene sorry can't tell you which one I don't have the paper work in front of me and is still on neocate. Blood tests all negative (except low iron)

I'd appreciate any help/suggestions

thanks

donna

[Kailynsmom]

IF the dr said that initial findings were abnormal, most likely that means celiac disease. Anemia is also VERY common with celiac disease, because the body isn't absorbing the vitamins and minerals from food.

Have you continued with the gluten-free diet?

[Guest DONNAJ]

[Thanks for your response. Is there anything else that "abnormal" could mean besides celiacs.

Also no she's not wheat/gluten free and hasn't been for the last 3 months in preparation for this op.

[CDFAMILY]

Hi Donna,

I thought my info on what happened to my daughter on a very slim gluten challange might be helpful. This is an old 1982 article on children and ferritin. My daughter was 17 at the time of the challange. She had had a negative biopsy in October but has had many serious physical problems which all point to Celiac. Mostly she had constant uncontrollable gas and burping since infancy which was only given an IBS dx. In 2004 I started a mega vitamin program for family because of my B12 deficiency that I found thanks to the internet. We started taking 5000mcg of methylcobalamin sublingual with folic acid and B complex. This just about cured both our gas and burping problems but we still had the fatigue. (I think this also repaired both of our upper small intestines as although I had very positive tTG and EMA, my damage was minor and DD was not visible but we were both still very sick.

Below is an article and her test results which I think are a good example of skipping biopsy and using blood work.

Open Original Shared Link

Am J Clin Pathol. 1982 Jan;77(1):82-6.

Related Articles, Links

Serum ferritin levels in celiac disease.

Souroujon M, Ashkenazi A, Lupo M, Levin S, Hegesh E.

Of the various common assayed parameters of iron metabolism, serum ferritin levels are the most discriminatory in distinguishing between non-treated celiac disease and other gastrointestinal disorders in the pediatric age group. Patients on normal diets usually have very low ferritin levels that increase at an average rate of 1 microgram/1/month when placed on a gluten-free diet. When the patient returns to a normal diet, however, ferritin levels decrease rapidly at an average rate of about 4 microgram/1/month. There is a relationship between abnormal intestinal changes and low ferritin levels in celiac disease with improvement in both when the patient is on a gluten-free diet. It is suggested that serial blood ferritin evaluations together with the leukocyte migration inhibition factor production assay should eliminate the need for invasive intestinal biopsies for the confirmation and possible follow-up to response to treatment.

PMID: 7055099 [PubMed - indexed for MEDLINE]

DD on very little gluten but lots of vitamins- Tested May 05

TIBC 424 (RANGE 222-400)

IRON 77 (RANGE 50-212)

FERRITIN 21 (RANGE 10-291)

SATURATION Not Taken

DD ON NO VITAMINS AND A LITTLE MORE GLUTEN BUT NOT ALL THAT MUCH ( started challenge around October after neg biop)- tested February 06

TIBC 527 (RANGE 222-400)

IRON 22 (RANGE 50-212)

FERRITIN 5 (RANGE 10-291)***( When the patient returns to a normal diet, however, ferritin levels decrease rapidly at an average rate of about 4 microgram/1/month)

SATURATION 4 (RANGE 16-35)

DD GLUTEN FREE 3 MONTHS and mega vitamins tested June 06

TIBC NT

IRON 149 (RANGE 50-212)

FERRITIN 23 (RANGE 10-291)-23 is still considered too low in my humble opinion

SATURATION 37 HIGH (RANGE 16-35)

Hope this helps,

Celiac Mom

Also another possible celiac disease blood sign is low or low normal lymphocytes.

[chrissy]

abnormal cells could mean a number of things. it could mean there are increased lymphocytes, like you would see with celiac. it could mean there are eosinophilic cells, like you would see with food allergies. it could also probably mean that there is damage. the microscopic findings on the cellular level are much more significant than the initial findings.

[kimber]

Hi

SORRY I can't be of any help, but your dd sounds just like my ds (but he'll be 3 in October)

We are seeing a new GI in a few weeks...and I plan to discuss testing

Is your dd underweight...my ped continues to dismiss celiac for my ds because he is small, but not underweight

of course I spend my day trying to get him to eat

Thanks for any info

abnormal cells could mean a number of things. it could mean there are increased lymphocytes, like you would see with celiac. it could mean there are eosinophilic cells, like you would see with food allergies. it could also probably mean that there is damage. the microscopic findings on the cellular level are much more significant than the initial findings.