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Help With Test Results!


KayKay

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KayKay Rookie

I recently had bloodwork and endoscopy/biopsy done and received results saying everything was normal,except a little anemic.I have been gluten-free for almost three weeks and feelin a little better. Here are my test results-

Transglutaminase AB IGA - result <3 negative is <5

Immoglobulin A- result 211 normal is 81-463

Anti-gliadin IGA <3 normal is <11

Anti-gliadin IGG <3 normal is <11

The biopsies were from the small bowel(4 samples) and gastric antum(3 samples) Results say no diagnostic abnormalities and normal length villa.

Am I correct that a anti-endomysial antibody and total IGA should have been done?And they can't be done unlees I start eating gluten again? I'm so disgusted with doctors right now. How can a GI doctor not know which tests to run when can look online and find out?!!!


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nikki-uk Enthusiast
I recently had bloodwork and endoscopy/biopsy done and received results saying everything was normal,except a little anemic.I have been gluten-free for almost three weeks and feelin a little better. Here are my test results-

Transglutaminase AB IGA - result <3 negative is <5

Immoglobulin A- result 211 normal is 81-463

Anti-gliadin IGA <3 normal is <11

Anti-gliadin IGG <3 normal is <11

The biopsies were from the small bowel(4 samples) and gastric antum(3 samples) Results say no diagnostic abnormalities and normal length villa.

Am I correct that a anti-endomysial antibody and total IGA should have been done?And they can't be done unlees I start eating gluten again? I'm so disgusted with doctors right now. How can a GI doctor not know which tests to run when can look online and find out?!!!

Ideally your doc could have done the EMA (anti- endomysial antibody) in conjunction with the other tests (looks like your Immunoglobulin A result listed is your total IGA) ...but being as your biopsy was negative it's very unlikely your doc would give you a diagnosis of celiac disease.

As you say you are gluten-free and feeling a bit better why not just stick with it? :)

There are many people here who do not have an 'official' diagnosis but know they feel better gluten-free.

Good Luck :)

tarnalberry Community Regular

there isn't a "obvious one set of tests" that all doctors agree on for celiac disease. you got a fairly thorough testing. the EMA is on it's way out as a test for celiac, and that "Immoglobulin A" test is likely a total IgA test. What seems missing is a tTg, but you can still get a decent story from 80% of the pages of a book, and this one is saying that you don't have diagnostically discernable celiac.

If you feel better gluten free, however, there's nothing that says you can't stay gluten free! :)

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    • trents
      Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for.
    • Scott Adams
      This article, and the comments below it, may be helpful:    
    • Scott Adams
      That’s a really tough situation. A few key points: as mentioned, a gluten challenge does require daily gluten for several weeks to make blood tests meaningful, but negative tests after limited exposure aren’t reliable. Dermatitis herpetiformis can also be tricky to diagnose unless the biopsy is taken from normal-looking skin next to a lesion. Some people with celiac or DH don’t react every time they’re exposed, so lack of symptoms doesn’t rule it out. Given your history and family cancer risk, this is something I’d strongly discuss with a celiac-experienced gastroenterologist or dermatologist before attempting a challenge on your own, so risks and benefits are clearly weighed.
    • Greymo
      https://celiac.org/glutenexposuremarkers/    yes, two hours after accidents ingesting gluten I am vomiting and then diarrhea- then exhaustion and a headache. see the article above- There is research that shows our reactions.
    • trents
      Concerning the EMA positive result, the EMA was the original blood test developed to detect celiac disease and has largely been replaced by the tTG-IGA which has a similar reliability confidence but is much less expensive to run. Yes, a positive EMA is very strong evidence of celiac disease but not foolproof. In the UK, a tTG-IGA score that is 10x normal or greater will often result in foregoing the endoscopy/biopsy. Weaker positives on the tTG-IGA still trigger the endoscopy/biopsy. That protocol is being considered in the US but is not yet in place.
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