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Gpc- Conjunctivitis


Lisa16

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Lisa16 Collaborator

Hi everybody!

I have almost finished reading Dr. Green's book, "Celiac Disease: The Hidden Epidemic"-- I highly recommend it. It answers a lot of questions I had and explains about autoimmune diseases and how, if you have one (like celiac disease), you are likely to have others.

Which made me think.... at one point I was diagnosed with GPC-- giant papillary conjunctivitis (stage 4 with striations, whatever that means.) It was explained to me that this was like a type of autoimmune disorder where your body attacks its own proteins in the lining aound the eye and scars the tissue. I was told I could not ever wear contact lenses again. Green doesn't talk about this one at all.

I also have DH (which is how the finally figured out the celiac disease,) so I know I have the IgA deposits in my skin. Related?

So does anyone know if there is a link between the celiac disease and the GPC? Have any of you had this too? because I am hoping that if going gluten-free can actually reverse some pretty serious things (and Green says it can) then maybe one day I can wear contacts again.

Lisa


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    • trents
      Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for.
    • Scott Adams
      This article, and the comments below it, may be helpful:    
    • Scott Adams
      That’s a really tough situation. A few key points: as mentioned, a gluten challenge does require daily gluten for several weeks to make blood tests meaningful, but negative tests after limited exposure aren’t reliable. Dermatitis herpetiformis can also be tricky to diagnose unless the biopsy is taken from normal-looking skin next to a lesion. Some people with celiac or DH don’t react every time they’re exposed, so lack of symptoms doesn’t rule it out. Given your history and family cancer risk, this is something I’d strongly discuss with a celiac-experienced gastroenterologist or dermatologist before attempting a challenge on your own, so risks and benefits are clearly weighed.
    • Greymo
      https://celiac.org/glutenexposuremarkers/    yes, two hours after accidents ingesting gluten I am vomiting and then diarrhea- then exhaustion and a headache. see the article above- There is research that shows our reactions.
    • trents
      Concerning the EMA positive result, the EMA was the original blood test developed to detect celiac disease and has largely been replaced by the tTG-IGA which has a similar reliability confidence but is much less expensive to run. Yes, a positive EMA is very strong evidence of celiac disease but not foolproof. In the UK, a tTG-IGA score that is 10x normal or greater will often result in foregoing the endoscopy/biopsy. Weaker positives on the tTG-IGA still trigger the endoscopy/biopsy. That protocol is being considered in the US but is not yet in place.
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