How Is This Possible?

[betty6333]

my son,6 has celiac ( his ttg was 92) but me DH, &DS all came back negative TTG 1..... how do two biological parents have ttg's of 1 have a child with celiacs if celiacs is genetic? be patient with us please as we are still in shock over all this.....

[Rachel--24]

Hi.

Many people carry the Celiac genes...however, not everyone actually develops the disease. The genes are inherited but this does not mean that every person with the genes will have Celiac Disease. The gene(s) are triggered in some people while others may never have their genes triggered.

Also, make sure that you were tested for IgA deficiency (total serum IgA). A person with IgA deficiency will not test positive for Celiac (even if they have it).

[betty6333]

Hi.

Many people carry the Celiac genes...however, not everyone actually develops the disease. The genes are inherited but this does not mean that every person with the genes will have Celiac Disease. The gene(s) are triggered in some people while others may never have their genes triggered.

Also, make sure that you were tested for IgA deficiency (total serum IgA). A person with IgA deficiency will not test positive for Celiac (even if they have it).

thanks, hopefully the rest of the kids will stay neg!

[~alex~]

my son,6 has celiac ( his ttg was 92) but me DH, &DS all came back negative TTG 1..... how do two biological parents have ttg's of 1 have a child with celiacs if celiacs is genetic? be patient with us please as we are still in shock over all this.....

Both my brother and I have Celiac disease and neither of our parents had it. Perhaps our parents' genes together combined to make us more vulnerable than either of them were or maybe we were exposed to something like an illness or life stressor that our parents never were that triggered the disease in us. Unfortunately I don't think there is enough known yet about why some people get celiac disease and others don't when they may have the same genes predisposing them to the disease.

I understand the shock your must be in finding out that your young son has a lifelong autoimmune condition. Although it does take quite a bit of learning at first and altering of old eating habits, if there was one lifelong condition I had to be saddled with, it would be Celiac disease. No meds means no side effects and no costs for prescriptions. And once your family gets the diet under control your son's intestines heal, he should be completely symptom free. Good luck and best wishes for a speedy recovery for your son.