Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Onset Of Celiac Disease


gfb1

Recommended Posts

gfb1 Rookie

i've noticed an increase in the frequency of postings regarding understanding of partially-positive or negative test results, in the face of celiac-like symptoms. conflicting test results also seem to be common.

celiac disease can be considered to be a 'threshold' disease. that is, blood test results and small bowel injury do not occur in a persons life until AFTER some 'threshold' or minimum level of gluten exposure. this threshold level appears to be extremely variable, taking into account both the degree to which one's gastrointestinal tract can metabollize gluten, one's level of inherent immune response to gliadin/gluten as it contacts the intestinal mucosa (probably the role of HLA alleles), the extent of one's immune response AFTER small bowel injury (i.e., following the entry of gliadin into the bloodstream) and, unsurprisingly, the amount of gluten one eats!!

a personal example;

my wife came from a 'meat and potatoes' family -- eating bread approx once per week-- with no health issues.

she had the misfortune of marrying some good looking italian 'guy', who (not to be stereotypical, but.... ) insisited on pasta twice a week and bread at every meal. worse, this poor fellow was a ny/nj-italian-american -- who introduced her to the wide, wonderful (but gliadically evil) world of bagels -- probably 5 times per week (the other 2 breakfasts were usually red bean cakes from chinatown...).

within 2 years, age 23, her health issues started and it took nearly 10 years to be diagnosed.

not a strange story, in and of itself... but, her dad -- who continued on the same meat/potatoes diet -- was only diagnosed with celiac disease 5 yrs ago at the unripe, young age of 77.

so, as equivocal test results start rolling in; remember that in order to consistently test 'postive' across all blood/biopsy tests; you really need to be eating gluten and have 'mature' celiac disease. perhaps contrary to expectations, some of the gastrointestinal outcomes of celiac disease, eg. bloating, gas, diarrhea, occur BEFORE all the clinical testing is postive.

this is probably why the 'old timers' in the group always tell the newcomers to try a gluten free diet for a few weeks to see if you feel better.

the difficulty with this approach involves the personal decision as to whether to re-introduce gluten into the diet in order to test positive...


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



nasalady Contributor
i've noticed an increase in the frequency of postings regarding understanding of partially-positive or negative test results, in the face of celiac-like symptoms. conflicting test results also seem to be common.

celiac disease can be considered to be a 'threshold' disease. that is, blood test results and small bowel injury do not occur in a persons life until AFTER some 'threshold' or minimum level of gluten exposure. this threshold level appears to be extremely variable, taking into account both the degree to which one's gastrointestinal tract can metabollize gluten, one's level of inherent immune response to gliadin/gluten as it contacts the intestinal mucosa (probably the role of HLA alleles), the extent of one's immune response AFTER small bowel injury (i.e., following the entry of gliadin into the bloodstream) and, unsurprisingly, the amount of gluten one eats!!

a personal example;

my wife came from a 'meat and potatoes' family -- eating bread approx once per week-- with no health issues.

she had the misfortune of marrying some good looking italian 'guy', who (not to be stereotypical, but.... ) insisited on pasta twice a week and bread at every meal. worse, this poor fellow was a ny/nj-italian-american -- who introduced her to the wide, wonderful (but gliadically evil) world of bagels -- probably 5 times per week (the other 2 breakfasts were usually red bean cakes from chinatown...).

within 2 years, age 23, her health issues started and it took nearly 10 years to be diagnosed.

not a strange story, in and of itself... but, her dad -- who continued on the same meat/potatoes diet -- was only diagnosed with celiac disease 5 yrs ago at the unripe, young age of 77.

so, as equivocal test results start rolling in; remember that in order to consistently test 'postive' across all blood/biopsy tests; you really need to be eating gluten and have 'mature' celiac disease. perhaps contrary to expectations, some of the gastrointestinal outcomes of celiac disease, eg. bloating, gas, diarrhea, occur BEFORE all the clinical testing is postive.

Very helpful post...thanks!

I should add that many of us who have battled with weight problems have tried every diet out there, and not surprisingly, discovered that we felt BEST on a low-carbohydrate diet....that it made our "IBS" subside or even go away entirely!

So we have unconsciously been on a "gluten-light" diet for years or even decades to control gastric discomfort as well as to lose weight. This definitely complicates things when we go see the doctor wanting a firm diagnosis! :)

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      130,595
    • Most Online (within 30 mins)
      7,748

    Diane Kuzina
    Newest Member
    Diane Kuzina
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • somethinglikeolivia
      When I underwent a scope three years ago, the GI told me I was negative for celiac because there was no intestinal damage (in spite of multiple strong positive labs). I went back to look at my biopsy report out of curiosity, and found this note: “Localized mild nodular mucosa was found in the duodenal bulb. Duodenum otherwise normal.” The pathology from this scope was negative. Does anyone have any insight into mild modular mucosa and what that could indicate or be a precursor to? I’ve read it can be a sign of celiac or other gut issues like h. Pylori, etc.  Thanks in advance! 
    • Rejoicephd
      Thank you @knitty kitty I really appreciate that suggestion as a way to reset and heal my gut - i will look into it !! 
    • Ginger38
      I also had high eosinophils which I’ve never had before either - could that be due to gluten consumption? 
    • knitty kitty
      You're welcome! Be sure the patient eats at least ten grams of gluten per day for a minimum of two weeks prior to repeating antibody testing.   Some people unconsciously reduce the amount of gluten in their diet because the feel unwell.  Three grams of gluten per day is sufficient to produce symptoms.  Only at ten grams or more is the immune system provoked to raise the antibody production high enough so that the antibodies leave the digestive tract and enter the blood stream where they can be measured.   Read the comments below the article...  
    • Wamedh Taj-Aldeen
      Thanks for your response and thoughts. Total IgA is normal. HLA DQ2/DQ8 came as heterozygous and the interpretation of the lab that the risk of coeliac disease is mild to moderate. Thyroid function test is normal. I agree that the best way is to repeat tTG antibodies in 6 months time as the result was not massively high.  
×
×
  • Create New...