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Please Help Need Someone To Read This Biopsy Result

eeskew7282

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eeskew7282 Rookie
eeskew7282
Posted

Here is the exact info from the report

Duodenal biopsy

Benign Duodenal Mucosa with MODERATE villous blunting and increased chronic inflammation of the Lamina propria.

Comment:

The villous architecture is moderately blunted and the lamina propria expanded by an increased compliment of mononuclear cells, to include plasma cells. Acute cryptitis or neutrophils are not noted. Eosiophils are not a significant component of the infiltrate. While few, scattered intraepithelial lymphocytes are present, they are not substantially increaseed. This finding is nonspecific, could be obsrved in treated malabsorption syndromes. Clinical correlation will be required.

*** I was on a gluten free diet three weeks prior to the biopsy and continue a gluten free diet.

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Lisa Mentor
Lisa
Posted

Although blunted villi are consistent and in many cases probable with Celiac, it is not specific to Celiac Disease.

Do you have a history of intestinal distress? Do you have an intolerance to cow's milk, gluten or soy?

Do you have an eating disorder? Have you be tested with a serologic panel for Celiac?

Your biopsy is a piece of the puzzle. While in some people, healing can be rapid, but I don't think three week would effect your biopsy.

I would certainly schedule a followup with your doctor.

gfb1 Rookie
gfb1
Posted
Here is the exact info from the report

Duodenal biopsy

Benign Duodenal Mucosa with MODERATE villous blunting and increased chronic inflammation of the Lamina propria.

Comment:

The villous architecture is moderately blunted and the lamina propria expanded by an increased compliment of mononuclear cells, to include plasma cells. Acute cryptitis or neutrophils are not noted. Eosiophils are not a significant component of the infiltrate. While few, scattered intraepithelial lymphocytes are present, they are not substantially increaseed. This finding is nonspecific, could be obsrved in treated malabsorption syndromes. Clinical correlation will be required.

*** I was on a gluten free diet three weeks prior to the biopsy and continue a gluten free diet.

i'm sure you'll get other replies; but, since i'm here...

since you are on a gluten-free diet, it will be very difficult to get 'clinical correlation'. that means blood tests to determine the cause of the 'villous blunting'. lots of threads around here that talk about eating gluten until AFTER all testing. otherwise all tests (blood/biopsy/etc) are suspect for celiac diagnosis.

as another thread somewhere over the last week or so has discussed, there are other disease states (besides celiac disease) that can cause villous blunting -- note the text in your report regarding 'malabsorption syndromes'.

in the absence of any other information (e.g., what other diseases can be ruled out or what other blood tests you have had) it is impossible to diagnose any disease from a single biopsy/blood test.

eeskew7282 Rookie
eeskew7282
Posted
  • Author
i'm sure you'll get other replies; but, since i'm here...

since you are on a gluten-free diet, it will be very difficult to get 'clinical correlation'. that means blood tests to determine the cause of the 'villous blunting'. lots of threads around here that talk about eating gluten until AFTER all testing. otherwise all tests (blood/biopsy/etc) are suspect for celiac diagnosis.

as another thread somewhere over the last week or so has discussed, there are other disease states (besides celiac disease) that can cause villous blunting -- note the text in your report regarding 'malabsorption syndromes'.

in the absence of any other information (e.g., what other diseases can be ruled out or what other blood tests you have had) it is impossible to diagnose any disease from a single biopsy/blood test.

I did have positive antibodies and antigen .. labs were all positive,, I have had GI stuff for years.

eeskew7282 Rookie
eeskew7282
Posted
  • Author
Although blunted villi are consistent and in many cases probable with Celiac, it is not specific to Celiac Disease.

Do you have a history of intestinal distress? Do you have an intolerance to cow's milk, gluten or soy?

Do you have an eating disorder? Have you be tested with a serologic panel for Celiac?

Your biopsy is a piece of the puzzle. While in some people, healing can be rapid, but I don't think three week would effect your biopsy.

I would certainly schedule a followup with your doctor.

I did have positive labs, positive antibody and positive antigen of 19

I have had GI issues for years and I do have problems with milk

Feel 100% better gluten-free

Lisa Mentor
Lisa
Posted
I did have positive labs, positive antibody and positive antigen of 19

I have had GI issues for years and I do have problems with milk

Feel 100% better gluten-free

Well then, coupled with a positive serologic test and blunted villi, it sounds like you have Celiac Disease. Welcome to the club!

Many people have issues with dairy early into the diet due to villious atrophy. After some healing has taken place, dairy is often re-introduced successfully.

eeskew7282 Rookie
eeskew7282
Posted
  • Author
Well then, coupled with a positive serologic test and blunted villi, it sounds like you have Celiac Disease. Welcome to the club!

Many people have issues with dairy early into the diet due to villious atrophy. After some healing has taken place, dairy is often re-introduced successfully.

thats good to know because I love dairy.. How long do you think I should wait before starting dairy?

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    • Xravith
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