How Do I Read These Test Results?

[amber2028]

I'm sorry if this is a really repetitive post, but I am at a loss for what else to do. I have an almost 2 year old who has had diarrhea 3+ times a day for almost 3 months. He has not gained any weight in 6 months. I am desperate to find out whats wrong with him. His pediatrician really has no clue what is wrong with him, so based off of my insistence and the recommendation of a pediatric GI we sent him for lab tests last week. His pediatric allergy test came back all negative, including wheat, and his Prometheus IBD Serology (Crohn's & Ulcerative Colitis) also came back negative. The rest of his results said that he was severely dehydrated and has some inflammation. I am at a total loss as to what the results of his Prometheus Celiac Serology mean. The summary was that the "Results may support a diagnosis of celiac disease, but are not specific." His pediatrician took that, and the fact that the allergy test came back negative for wheat, as he doesn't have it. Here is the actual test results. I will be so grateful for anyone who can help me understand what they mean!

AGA IgG +

AGA IgA -

TTG IgA -

EMA IgA -

Anti-Gliadin IgG ELISA (AGA IgG) 11.3 U/ml

Anti-Gliadin IgA ELISA (AGA IgA) <1.2 U/ml

Anti-Human Tissue Transglutaminase tgA ELISA (TTG IgA) <1.2 U/ml

Anti-Edomysial IgA IEA (EMA IgA) Negative

Total Serum IgA by Nephelometry (Total IgA) 58 mg/dl

[ravenwoodglass]

I'm sorry if this is a really repetitive post, but I am at a loss for what else to do. I have an almost 2 year old who has had diarrhea 3+ times a day for almost 3 months. He has not gained any weight in 6 months. I am desperate to find out whats wrong with him. His pediatrician really has no clue what is wrong with him, so based off of my insistence and the recommendation of a pediatric GI we sent him for lab tests last week. His pediatric allergy test came back all negative, including wheat, and his Prometheus IBD Serology (Crohn's & Ulcerative Colitis) also came back negative. The rest of his results said that he was severely dehydrated and has some inflammation. I am at a total loss as to what the results of his Prometheus Celiac Serology mean. The summary was that the "Results may support a diagnosis of celiac disease, but are not specific." His pediatrician took that, and the fact that the allergy test came back negative for wheat, as he doesn't have it. Here is the actual test results. I will be so grateful for anyone who can help me understand what they mean!

AGA IgG +

AGA IgA -

TTG IgA -

EMA IgA -

Anti-Gliadin IgG ELISA (AGA IgG) 11.3 U/ml

Anti-Gliadin IgA ELISA (AGA IgA) <1.2 U/ml

Anti-Human Tissue Transglutaminase tgA ELISA (TTG IgA) <1.2 U/ml

Anti-Edomysial IgA IEA (EMA IgA) Negative

Total Serum IgA by Nephelometry (Total IgA) 58 mg/dl

The fact that he is not allergic to wheat is of no relevance. Celiac is not an allergy. His total IGA is pretty low so that would throw the IGA tests off. It could cause a false negative. However his IgG was postive which is the test that I think would be looked at with an IGA deficit.

Unless you plan to have an endoscopy done by a GI doctor I would get him on the diet.

[Luvbeingamommy]

The fact that he is not allergic to wheat is of no relevance. Celiac is not an allergy. His total IGA is pretty low so that would throw the IGA tests off. It could cause a false negative. However his IgG was postive which is the test that I think would be looked at with an IGA deficit.

Unless you plan to have an endoscopy done by a GI doctor I would get him on the diet.

That looks very similar to mt blood work, if I remember right. I got a negative biopsy though . I am getting a copy of my results tomorrow.

My 2 year old also has loose stools and still gaining, but slowed down a lot. I just got his celiac panel done today.

[ravenwoodglass]

That looks very similar to mt blood work, if I remember right. I got a negative biopsy though . I am getting a copy of my results tomorrow.

My 2 year old also has loose stools and still gaining, but slowed down a lot. I just got his celiac panel done today.

There can be false negatives on both blood and biopsy so do try the diet strictly for a bit no matter what the results.

[Luvbeingamommy]

There can be false negatives on both blood and biopsy so do try the diet strictly for a bit no matter what the results.

So what is the gold standard to be diagnosed? Why do some do the gene test??

[nora-n]

In smal children, the immune restonse is not that high.

Here the total IgA is not that high either.

We have seen some abstracts on pubmed.com that say the antigliadin IgG is more accurate in small children, meaning that it is probably celiac with a positive antigliadin IgG.