Just Got My Biopsy Results, Who Can Help Decipher How Bad The Damage Is?

[SaraKat]

My Dr said it was just positive, he didn't mention a scale rating or anything which I have heard used on this site before. I guess the gastric one is self explanatory, but the duodenum one is the questionable one, does anyone know if this is really bad?

DIAGNOSIS:

A-Duodenum biopsy:

Fragments of duodenal mucosa with marked villous blunting and atrophy associated with increased lamina propria mononuclear inflammatory cells and eosinophils compatible with celiac disease. Negative for dysplasia or malignancy.

B- Gastric biopsy:

Gastric mucosal fragments, no diagnostic abnormality. Immunohistichemical stain for H.Pylori is negative. AB/PAS stain is unremarkable. Negative for malignancy.

I also got some blood work done right before the biopsy and it seems really HIGH!!

TTG IGA is >100 (normal says <4)- this is weird too because another Dr tested it 2 weeks before and it was only 38.

Reticulin AB: negative (not sure what this is)

Gliadin Panel:

IgG: is 131, negative <20

IgA: >400, negative <20

Endomysial AB

Endo Antibodies IgA: Positive, titer 1:320

These #'s seem really high, esp that >400 one.

He told me I have to come back in 2 months for follow up blood-work and he said if I stick to the diet these #'s should go back to normal. He told me to take a multi vitamin and iron pills too.

Thanks!

[Skylark]

Well, no question you're celiac!

If you scroll down to the "pathology" section here it explains the Marsh grading.

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I'd think you are Marsh 3? It doesn't matter how bad the biopsy is, as you will get better on the gluten-free diet. It may take you a little longer than someone without as much villous damage and you're going to have to be really strict.

Reticulin is the old name for anti-endomysial by the way.

[Looking for answers]

Be careful taking strong vitamins right now, it may make you feel worse. Consider a whole food or liquid vitamin. I LOVE Garden of Life's iron pills...you can take them on an empty stomach and they won't cause upset. If you've never taken iron before, the regular ones can be quite distressing on the digestive track.

Good luck to you. We look forward to your progression!