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melikamaui

Trying To Understand How To Read These Results

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Can anyone help me figure out this genetic panel? These are my son's results. I know he has a very high chance of having celiac disease, and his doctor believes that he does in fact have it, she diagnosed him already. I'd just like to know what each of these things stand for.

Thanks for any help.

002.5 (HLA OOA1*05:00B1"(201) and other non-risk alleles.

Category 4, DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

Category 8, DQ2 Homozygous, Increased Risk 31X, Relative Risk EXTREMELY HIGH

Category 7, DQ2/other high risk gene, Increased Risk 16X, Relative Risk VERY HIGH

Category 6, DQ2/DQ8, Increased Risk 14X, Relative Risk VERY HIGH

Category 5, DQ8 Homozygous, Increased Risk 10X, Relative Risk HIGH

Category 4, DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

Category 3, DQ8 heterozygous, Increased Risk 2X, Relative Risk MODERATE

Category 2, DQ2/other low risk gene, Increased Risk <1X, Relative Risk LOW

Category 1, DQx, DQ8, Increased Risk <o.1, Relative Risk EXTREMELY LOW

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What category does he fall in? I only see his other risk alleles

DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

What do/does the other risk alleles mean? I don't understand that part at all.

Thanks for any help!

Melika

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He has one risk allele, DQ2.5, and one non-risk allele which hasn't been specified. That gives him 10x risk for celiac with respect to the general US population.

I'm not sure what else you're asking. What do you mean by "each of these things"? Is this article helpful?

http://en.wikipedia.org/wiki/HLA-DQ

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I do not understand the difference between category 1 and 3 in this list


gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.

daughter officially diagnosed celiac and casein intolerant.

non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5

Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet

Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

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