Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Iga False Negative To Gluten And Other Known Problems

1desperateladysaved

Recommended Posts

1desperateladysaved Proficient
1desperateladysaved
Posted

I remember reading that Celiacs often false negative on the IGA tests. My tests were all about 0 antibodies. Please just assume that we know that I have allergies/intolerances to atleast some of the foods/airborne allergies on the test. Why do Celiacs have false negative tests?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GottaSki Mentor
GottaSki
Posted

This is one area that needs more research - there are people that are diagnosed by positive endoscopic biopsy that have all negative blood work. Current testing is not yet accurate enough. Here are two reasons I can think of for false negatives with current tests:

Time gluten-free before blood draw.

Insufficient IgA - this is the reason for the Total Serum IgA blood test. If a person doesn't have sufficient IgA, they can't make the antibodies that are tested for in the tTG IgA and other IgA tests of the celiac blood panel.

1desperateladysaved Proficient
1desperateladysaved
Posted
  • Author

GottaSki: "Insufficient IgA - this is the reason for the Total Serum IgA blood test. If a person doesn't have sufficient IgA, they can't make the antibodies that are tested for in the tTG IgA and other IgA tests of the celiac blood panel."

Would this be an autoimmune problem? Would it be damage to the small intestine? I think I heard that antibodies are manufactored by the small intestine.

Anymore clues?

Diana

GottaSki Mentor
GottaSki
Posted

Would this be an autoimmune problem? Would it be damage to the small intestine? I think I heard that antibodies are manufactored by the small intestine.

Anymore clues?

Diana

I'm not sure I understand your question.

Being deficient in one immunoglobulin does not mean you can't make antibodies at all. It is possible to have celiac damage with deficient IgA.

It is my understanding that antibodies are created and released by a white blood cells called plasma cells in response to a foreign substance the body perceives as threatening. In Celiac Disease gluten proteins are perceived as the foreign substance - the immune response that follows destroys the intestinal lining.

As far as I know - there has not been enough research to determine the mechanisms that cause symptoms in Non-Celiac Gluten Intolerance.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Scott Adams
      - Scott Adams commented on Scott Adams's article in Additional Concerns
      4

      Going Low-Gluten May Harm Good Gut Bacteria, Researchers Warn

      Researchers are working on T cell modification therapy that could one day let celiacs eat gluten.
    2. chrisinpa
      - chrisinpa commented on Scott Adams's article in Additional Concerns
      4

      Going Low-Gluten May Harm Good Gut Bacteria, Researchers Warn

      It's like a double edged sword.......we do one thing to improve a problem and cause another problem. I'd like to think the ultimate cure might be something that would train or modify the body to prevent the damage that gluten causes.
    3. Flash1970
      - Flash1970 replied to Ginger38's topic in Related Issues & Disorders
      7

      Shingles - Could It Be Related to Gluten/ Celiac

      You might try Heallix. It's a silver solution with fulvic acid. I just put the solution on with a cotton ball. It seemed to stop the nerve pain. Again, not in your eyes or ears. Go to heallix.com to read more about it and decide for yourself Also, I do think nerve and celiac combined have a lot to do with your susceptibility to shingles breaking out...
    4. trents
      - trents replied to Roses8721's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      10

      GI DX celiac despite neg serology and no biopsy

      Celiac disease requires both genetic potential and a triggering stress event to activate the genes. Otherwise it remains dormant and only a potential problem. So having the genetic potential is not deterministic for celiac disease. Many more people have the genes than actually develop the disease. But if you don't have the genes, the symptoms are likely being...
    5. Roses8721
      - Roses8721 replied to Roses8721's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      10

      GI DX celiac despite neg serology and no biopsy

      Yes, i pulled raw ancetry data and saw i have 2/3 markers for DQ2.2 but have heard from friends in genetics that this raw data can be wildly innacurate
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,492
    • Most Online (within 30 mins)
      7,748
    K Zappe
    Newest Member
    K Zappe
    Joined
  • Celiac.com Sponsor (A20):

  • Celiac.com Sponsor (A22):



  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Flash1970
      Shingles - Could It Be Related to Gluten/ Celiac

      By Flash1970 · Posted

      You might try Heallix.  It's a silver solution with fulvic acid. I just put the solution on with a cotton ball.  It seemed to stop the nerve pain. Again,  not in your eyes or ears.   Go to heallix.com to read more about it and decide for yourself Also,  I do think nerve and celiac combined have a lot to do with your susceptibility to shingles breaking out. 
    • trents
      GI DX celiac despite neg serology and no biopsy

      By trents · Posted

      Celiac disease requires both genetic potential and a triggering stress event to activate the genes. Otherwise it remains dormant and only a potential problem. So having the genetic potential is not deterministic for celiac disease. Many more people have the genes than actually develop the disease. But if you don't have the genes, the symptoms are likely being caused by something else.
    • Roses8721
      GI DX celiac despite neg serology and no biopsy

      By Roses8721 · Posted

      Yes, i pulled raw ancetry data and saw i have 2/3 markers for DQ2.2 but have heard from friends in genetics that this raw data can be wildly innacurate
    • Ginger38
      Shingles - Could It Be Related to Gluten/ Celiac

      By Ginger38 · Posted

      Thanks, I’m still dealing with the pain and tingling and itching and feeling like bugs or something crawling around on my face and scalp. It’s been a miserable experience. I saw my eye doc last week, the eye itself was okay, so they didn’t do anything. I did take a 7 day course of an antiviral. I’m hoping for a turnaround soon! My life is full of stress but I have been on / off the gluten free diet for the last year , after being talked into going back on gluten to have a biopsy, that looked okay. But I do have positive antibody levels that have been responsive  to a gluten free diet. I can’t help but wonder if the last year has caused all this. 
    • Scott Adams
      Help

      By Scott Adams · Posted

      I don't think any apps are up to date, which is exactly why this happened to you. Most of the data in such apps is years old, and it doesn't get updated in real time. Ultimately there is no substitution for learning to read labels. The following two lists are very helpful for anyone who is gluten sensitive and needs to avoid gluten when shopping. It's very important to learn to read labels and understand sources of hidden gluten, and to know some general information about product labelling--for example in the USA if wheat is a possible allergen it must be declared on a product's ingredient label like this: Allergens: Wheat.      
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.