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Exact Details Of Endocscopic Biopsy

tendyourspirit

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tendyourspirit Newbie
tendyourspirit
Posted

Hi all, I hope you can help me in a hurry. It's been so long since I went through my biopsy that I cannot recall the appropriate methodology for the endoscopy. My mom is having an endoscopy for another reason but had bloodwork done last week that indicated that it might be prudent to check for celiac disease/villi damage. Anyhow I am fairly confident that her GI is not too knowledgable in this area and she won't switch her procedure at this point to someone in the area who is more knowledgable with celiac disease, but she is willing to have her GI pull the biopsy for celiac disease. So now I need to give her very specific information as to what to give to him re: what needs to be done for a proper biopsy. Even if he knows what to do, if nothing else, it will help to educate her. For some reason despite my surfing and net abilities I can't seem to pull this information off the net. Can anyone help me out here? She needs to call him ASAP and so any input would be appreicated.

It's great to finally join y'all. I'm a newbie here.

Thanks so much!

Andrea

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lovegrov Collaborator
lovegrov
Posted

I don't think I have all the details you need but I DO know that he needs to take something 8-10 samples from various areas of the small bowel. Damage can be spotty and if you take just 2 or 3 samples you can miss it. If he doesn't know what he's looking for he needs to let somebody with more expertise read the slides.

richard

gf4life Enthusiast
gf4life
Posted

One thing they need to do when they take the biopsies (and most doctors don't do this) is to look at the tissue samples on the cellular level. I think it is called a celiac disease-3 stain. They can then count the number of lymphocytes (anything over 20 is conscidered celiac disease). This would only need to be done in the absence of visible damage to the villi, but it needs to be specially requested by the doctor or the lab won't do it.

I found this out too late, and since I had no visible damage I do not have the diagnosis. I will NOT do another gluten challenge (the first one was horrible) and so I will have to wait until they accept Enterolab in the mainstream medical field.

God bless,

Mariann

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    • NanceK
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      @Hmart, The reason why your intestinal damage was so severe, yet your tTg IgA was so minimal can be due to cutting back on gluten (and food in general) due to worsening symptoms.  The tTg IgA antibodies are made in the intestines.  While three grams of gluten per day for several weeks are enough to cause gastrointestinal symptoms, ten grams of gluten per day for for several weeks are required to provoke sufficient antibody production so that the antibodies move out of the intestines and into the blood stream where they can be measured in blood tests.  Since you reduced your gluten consumption before testing, the antibody production went down and did not leave the intestines, hence lower than expected tTg IgA.   Still having abdominal pain and other symptoms this far out is indicative of nutritional deficiencies.  With such a severely damaged small intestine, you are not absorbing sufficient nutrients, especially Thiamine Vitamin B 1, so your body us burning stored fat and even breaking down muscle to fuel your body.   Yes, it is a very good idea to supplement with vitamins and minerals during healing.  The eight essential B vitamins are water soluble and easily lost with diarrhea.  The B vitamins all work together interconnectedly, and should be supplemented together.  Taking vitamin supplements provides your body with greater opportunity to absorb them.  Thiamine and the other B vitamins cannot be stored for long, so they must be replenished every day.  Thiamine tends to become depleted first which leads to Gastrointestinal Beriberi, a condition that doctors frequently fail to recognize.  Symptoms of Gastrointestinal Beriberi are abdominal pain and nausea, but neuropathy can also occur, as well as body and joint pain, headaches and more.  Heart rhythm disruptions including tachycardia are classic symptoms of thiamine deficiency.  Heart attack patients are routinely administered thiamine now.   Blood tests for vitamins are notoriously inaccurate.  You can have "normal" blood levels, while tissues and organs are depleted.  Such is the case with Gastrointestinal Beriberi, a thiamine deficiency in the digestive tract.  Eating a diet high in carbohydrates, like rice, starches, and sugar, can further deplete thiamine.  The more carbohydrates one eats, the more thiamine is required per calorie to turn carbs into energy.  Burning stored fats require less thiamine, so in times of thiamine shortage, the body burns fat and muscles instead.  Muscle wasting is a classic symptoms of thiamine deficiency.  A high carbohydrate diet may also promote SIBO and/or Candida infection which can also add to symptoms.  Thiamine is required to keep SIBO and Candida in check.   Thiamine works with Pyridoxine B 6, so if Thiamine is low and can't interact with Pyridoxine, the unused B 6 accumulates and shows up as high.   Look into the Autoimmune Protocol diet.  Dr. Sarah Ballantyne is a Celiac herself.  Her book "The Paleo Approach" has been most helpful to me.  Following the AIP diet made a huge improvement in my symptoms.  Between the AIP diet and correcting nutritional deficiencies, I felt much better after a long struggle with not feeling well.   Do talk to your doctor about Gastrointestinal Beriberi.  Share the article linked below. Thiamine, gastrointestinal beriberi and acetylcholine signaling https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/ Keep us posted on your progress!
    • Trish G
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    • trents
      Is this celiac?

      By trents · Posted

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    • trents
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      By trents · Posted

      knitty kitty asks a very relevant question. So many people make the mistake of experimenting with the gluten free diet or even a reduced gluten diet soon before getting formally tested.
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