Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Blood Tests And Gluten Challenge
0

6 posts in this topic

Hi. I'm new to the forum, but not new to celiac disease. My daughter, now 46 was born with it. I was told I probably had it (by a physician) but never tested until this yr. First test I had been strictly gluten -free for 2 mos. IGA and IGG were negative. So was the endomesial antibody IGA.

So I did a gluten challenge for three weeks. Tested again. Everything negative but Endomesial antibody went up to just enter the positive range, exactly 1:5.

I'm thinking now I should be on gluten a longer time and test again, because the longer I am on a ciet containing gluten, the more digestive distress I am having.

1. Can anyone explain what the higher endomesial antibody test results might indicate? Should I pursue more testing after a longer gluten challenge?

2. What is an ARA test? Should I have had it or did I already under one of the other names?

3. The nurse read my report to me over the phone, at my request, and mentioned a term that included the words tissue transference (not sure I got it right, but the number she gave me on that was 13, whatever that may mean.

I will meet with my dr. and get these things clear, but frankly I don't think she knows that much about celiac disease or the tests.

I'd like to go armed with the right questions to ask! :)

Thanks for sharing iwhatever nformation you can. Elsie

p.s. I've suffered digestive problems all my life, sometimes called colitis and more recently irritable bowel or "food sensitivities." After being treated for non-hodgkins lymphoma two yrs. ago and learning the higher risk for that among Celiac patients I feel I need to get serious about a definite diagnosis to preserve my present health.

0

Share this post


Link to post
Share on other sites


Ads by Google:

Here's a great site for explaining all those acrnyms:

http://labtestsonline.net/

I hope you find an answer soon. It sounds like you would definitely benefit from a gluten-free lifestyle.

Hope this helps!

Karen

0

Share this post


Link to post
Share on other sites

Karen, thanks. I checked the site and obtained some useful information. Elsie

0

Share this post


Link to post
Share on other sites

I think I may be able to help.

I think the test (#3 on your list) is called Tissue transglutamase

Here is a link to a laboratory test information guide for this test:

http://www.lhsc.on.ca/cgibin/view_labtest....mase%20antibody

If this was the test you had and you had a reading of 13 than I think it means you MAY have tested positive for celiac (I'm not a doctor!). It says on the website that a normal reading is less than 10 U/ml. But it also says "Tissue Transglutamase may give persistent mildly elevated results in the absence of disease". Definitely worth looking into! Of coarse check this info with your doctor.

Tissue transglutamase is the blood test that I had and I was told that this blood test is vey specific for celiac disease.

0

Share this post


Link to post
Share on other sites

Different labs use a different reference range. For the Tissue Transglutaminase test most labs say under 20 is negative, a few use under 10 as negative. It is the most specific bloodtest for Celiac.

ARA is Anti-Reticulin Antibody. It is as far as I can tell an outdated bloodtest that very few doctors or labs rely on anymore for Celiac testing. It is still included in some celiac panels though. On mine it said I was negative for the screening test for it, so the actual test was never performed.

The fact that your IgA endomysial antibody went up when you went back on gluten is an indication that gluten may be causing your symptoms, but if you want a definative diagnosis you would have to go back on gluten for anywhere from 3-6 months or more to get more accurate test results. Otherwise you could just continue on the gluten free diet and see if it helps. I went back on gluten for two months and it was not long enough to show my doctor the damage she wanted to see to give the diagnosis of Celiac. I opted for Enterolab testing to get my answers. I am very happy with their testing methods and it is certainly an option. You can check them out at http://www.enterolab.com

God bless,

Mariann

0

Share this post


Link to post
Share on other sites




ARA can - as far as I've been able to discover - indicate either autoimmune kidney problems as well, but usually celiac. It's actually relatively specific (in theory), but not very sensitive. (Plenty of celiacs won't have it raised.) That, actually, was my only positive test. (I couldn't get any values on the rest, so I don't know if they were borderline.) When I combined that with a positive result when going on the diet - and doing a dietary challenge - I took that as my answer. It is an indirect test though, and definitely not too many doctors run it any more.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,625
    • Total Posts
      918,382
  • Topics

  • Posts

    • puffiness in face
      The puffiness in my face went down a lot after I went gluten free. Old photos shock me sometimes now! Your doctor should be able to test you for food intolerance? Here in UK I did tests for wheat, nut, mustard etc. You can do a blood test and there's also skin prick tests I think, am sure others here would know more.  Good luck    
    • glutened by lays potato chips?
      Here in the UK I can't eat Lay's owned Walkers crisps as even the ones without gluten ingredients can cause a reaction. I read it was something to do with their production processes. Looks like others have same problems too:  
    • Newly diagnosed and totally overwhelmed
      Don't apologise! Not needed here at least where people know exactly what you're going through. As Cyclinglady says, you're now in a grieving process for the former, carefree attitude to food you've now lost. You may find this helpful in understanding the psychological journey you're on: http://psychcentral.com/lib/the-5-stages-of-loss-and-grief/ It WILL get better. Eating cleanly is very good advice as you heal but you can then find the replacement snacks and treats that are safe to eat.  I now know which chocolate bars are ok, which brands of crisps (chips) are safe etc.  I don't drink now, but I did find there were some fantastic ciders that I could tolerate and you've always got wine! In fact one of the weirder discoveries post gluten was that my past (vicious) hangovers were far more about gluten reactions than the alcohol itself. A cider hangover is a breeze in comparison All the best!  
    • glutened by lays potato chips?
      I ate some baked lays last night and felt very sick all night and haven't been feeling great all day today. Other than that I didn't eat anything different from what I normally eat and there was no risk of cross contamination with anything.. These were the only thing I had that was different. They're labeled gluten free so I figured it would be okay, but I started feeling sick pretty soon after eating them. I'm not sure if it's another ingredient in them or what (and i know it's not the soy).. Has anyone else had a reaction to lays potato chips?
    • Symptoms In Toddlers?
      Welcome Ashley! Here are the current tests.  The DGP versions seem to work a bit better than the TTG in small children.  So, ask for the complete panel (and get it all in one stick....my 15 year still hates to get blood drawn ! http://www.cureceliacdisease.org/screening/ Your doctors are wrong!  They must be reading old medical text books.  Not all kids or people have failure to thrive!  You can even be symptom free!. I was anemic and had no intestinal issues when I was diagnosed.  celiac disease affects everyone differently and that's probably why so many folks are not diagnosed. Your kids (parents, siblings too) should be tested every few years (sooner if symptoms develop) per all the leading celiac researchers/doctors if a first-degree relative has celiac disease (like you!)  celiac disease can develop at any age! Hope this helps!   
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,718
    • Most Online
      1,763

    Newest Member
    Flora Simpson
    Joined