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Recent Activity
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- Aretaeus Cappadocia replied to Anne G's topic in Related Issues & Disorders2celiac disease and braces
Your concerns are reasonable about the celiac risk aspect, and getting additional medical input is a good idea. Obviously I don't know the extent of your child's misalignment, but please don't think of it as just a cosmetic issue. Braces improve bite alignment and typically provide long term health benefits. -
- Aretaeus Cappadocia replied to Ginger38's topic in Related Issues & Disorders26
Shingles - Could It Be Related to Gluten/ Celiac
I watched my spouse go through shingles before the vaccine was available for "younger" people, so I got the vaccine as soon as I could. It really knocked me down too, especially the second dose. Even with that, if necessary I would take that vaccine every year to avoid getting shingles. Luckily it's a lifetime benefit though. -
- Lotte18 replied to Lotte18's topic in Publications & Publicity2Prospective CRISPR research
Hi Aretaeus, Thanks for posting these articles. The second of the two relates to my query. Last week there was a podcast by the Washington Post with the director of the NIH and CDC. Both institutions are now headed by one guy, Dr. Bhattacharya. He claims that research funding for rare diseases has NOT been cut. The question still remains, how do...- 1
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- Aretaeus Cappadocia replied to Lotte18's topic in Publications & Publicity2
Prospective CRISPR research
I saw your post and it made me curious so I did a little online research. While I could not find "Theresa Flores" or any human celiac CRISPR studies, I found 2 articles that are perhaps relevant to your questions: 1. "T cell receptor precision editing of regulatory T cells for celiac disease" Mar 2025 (https://www.science.org/doi/10.1126/scitranslmed... -
- trents replied to Healthierbody2026's topic in Related Issues & Disorders15New at gluten sensitivity
@Healthierbody2026, so you say here that you were diagnosed a few years back but in your first post you say you were recently diagnosed. I am totally confused!
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By Aretaeus Cappadocia · Posted
Your concerns are reasonable about the celiac risk aspect, and getting additional medical input is a good idea. Obviously I don't know the extent of your child's misalignment, but please don't think of it as just a cosmetic issue. Braces improve bite alignment and typically provide long term health benefits. -
By Aretaeus Cappadocia · Posted
I watched my spouse go through shingles before the vaccine was available for "younger" people, so I got the vaccine as soon as I could. It really knocked me down too, especially the second dose. Even with that, if necessary I would take that vaccine every year to avoid getting shingles. Luckily it's a lifetime benefit though. -
Hi Aretaeus, Thanks for posting these articles. The second of the two relates to my query. Last week there was a podcast by the Washington Post with the director of the NIH and CDC. Both institutions are now headed by one guy, Dr. Bhattacharya. He claims that research funding for rare diseases has NOT been cut. The question still remains, how do we get Celiac on their radar when of course we are competing for dollars with all kinds of other diseases? Are people in our community interested in a CRISPR cure? It seems to me CRISPR works at odds with big pharma because it actually IS a cure. You wouldn't have to take a drug to suppress T cell inflammation for the rest of your life. CRISPR is supposed to permanently rewrite your DNA. I assume we would really need the NIH to fund that research, not rely drug companies. Dr. Dounda, the brilliant microbiologist, who won the Nobel for her research, making CRISPR possible, thinks that the hefty price will diminish as treatment migrates from bone marrow transplant to infusion therapy. Because Stanford University started studying celiac and CD8 cells a few years ago, I was curious to see if any progress had been reported. What I found was a proposal to create a CRISPR platform for celiac by Theresa Flores. I haven't found anything that states whether or not she got funding. If anyone at Celiac.com has seen something, please let me know before I start composing a letter to Dr. Bhattacharya. Not that one little voice in the wilderness is going to move the needle. If others would also like to write to him, or help compose a joint letter, that would be great.
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By Aretaeus Cappadocia · Posted
I saw your post and it made me curious so I did a little online research. While I could not find "Theresa Flores" or any human celiac CRISPR studies, I found 2 articles that are perhaps relevant to your questions: 1. "T cell receptor precision editing of regulatory T cells for celiac disease" Mar 2025 (https://www.science.org/doi/10.1126/scitranslmed.adr8941). "Cell Therapy for Celiac Disease. The cover image shows CD4+ T cells (green) engineered to express a gluten-specific T cell receptor (TCR) in the duodenal mucosa and Peyer’s Patch of a mouse that received an oral administration of gluten. B cells are shown in red, dendritic cells in white, and nuclei in blue. Currently, the only approach to manage celiac disease is a strict and costly gluten-free diet, highlighting the unmet need for therapeutics. Porret et al. opted for a cell therapy approach by engineering regulatory T cells (Tregs) to express a gluten-specific TCR. They found that these engineered Tregs could suppress conventional gluten-reactive CD4+ T cells in vitro and in vivo after exposure to gluten. These data suggest that engineered Tregs already in the clinic for other disease indications may offer a cell therapy for celiac disease." In other words, in a mouse model of celiac, researchers were able to demonstrate creation of genetically modified cells that block a key step in the celiac pathway. This shows some promise for making it into human trials. 2. "CRISPR Clinical Trials: A 2025 Update" Jul 2025 (https://innovativegenomics.org/news/crispr-clinical-trials-2025/) This review did not mention any human CRISPR studies related to celiac disease. -
@Healthierbody2026, so you say here that you were diagnosed a few years back but in your first post you say you were recently diagnosed. I am totally confused!
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