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Study Supports Gluten-free Diet for 'Potential' Celiac Disease Patients


New study indicates more people should be gluten-free.

Celiac.com 12/26/2010 - Should everyone with symptoms of celiac disease go on a gluten-free diet? Current practice allows many patients with symptoms of celiac disease, but no gut damage, and thus no official diagnosis, to forgo a gluten-free diet.

In a new study, researchers found that people with celiac disease symptoms have the same distinctive metabolic fingerprint as patients with full-blown disease, and who must follow a gluten-free diet to avoid permanent damage to the gut.

The new study, by Ivano Bertini and colleagues, is stirring up the discussion about just which patients with symptoms of celiac disease should follow a gluten-free diet.

Their research shows that people currently diagnosed as "potential" celiac disease patients and not advised to follow a gluten-free diet may not be "potential" patients at all.

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Celiac disease is widely regarded as undiagnosed or misdiagnosed. For their study, the researchers used magnetic resonance metabolic profiling to analyze the biochemical markers in the blood and urine of 61 patients with celiac disease, 29 with potential celiac disease, and 51 healthy people.

The researchers found that people with unproven celiac disease largely shared the same profile as those with confirmed celiac disease and that the biochemical markers in both groups differed sharply from those of healthy individuals.

The researchers conclude that their findings "demonstrate that metabolic alterations may precede the development of small intestinal villous atrophy and provide a further rationale for early institution of gluten-free diet in patients with potential celiac disease, as recently suggested by prospective clinical studies."

The authors do note receiving funding from Boehringer Ingelheim Italy.

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2 Responses:

 
Teresa
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said this on
27 Dec 2010 10:41:27 PM PST
I would like to know if the patients had any celiac blood panels done, and whether those with the similar metabolic panels as celiacs already had developed antibodies, and whether they were followed up with biopsy... and what they showed. It is not cost effective to test everyone with any one of a dozen or more symptoms... so what will become the best screening tool?

 
Will Smith
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said this on
30 Dec 2010 5:54:30 AM PST
I do not have celiac disease-wrong genes, no villi damage However, I am highly gluten intolerant. I have lost half of my kidney function from IgA Nephropathy caused by gluten reactions. Mayo Clinic routinely checks people with this condition for celiac disease, but there is no check for gluten intolerance. Have your doctor monitor your kidney function if you are gluten intolerant and continue to eat it anyway.




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