No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Dutch Team Completes Major Group Study of Celiac Characteristics

Celiac.com 03/07/2016 - Even though doctors know a lot more about celiac disease than they did just a few years ago, and even though they are learning more all the time, there are still very few detailed clinical descriptions of large groups of celiac patients.

Photo: CC--Roman BoedRecently, a team of researchers reviewed a large Dutch cohort of celiac patients to create an overview that focused on symptom presentation, co-occurrence of immune mediated diseases and malignancies.

The research team included M Spijkerman, IL Tan, JJ Kolkman, S Withoff, C Wijmenga, MC Visschedijk, and RK Weersma. They are variously associated with the Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen; the Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands, and with the Department of Gastroenterology and Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands.

To create their overview, the team performed a retrospective study in a Dutch university and a non-university medical hospital that included only patients with biopsy proven (≥Marsh type 2 classification) celiac disease.

The team selected 412 patients from 9,468 small-bowel biopsy pathology reports and financial codes. About a third of the group showed classical celiac symptoms, including diarrhea (37.4%), fatigue (35.0%), weight loss (31.6%), abdominal pain (33.3%).

Ads by Google:

Around 10% showed atypical symptoms, including constipation (10.4%) and reflux (12.4%), while nearly 12% were diagnosed without any reported symptoms.

About one in four patients also had immune-mediated diseases, most commonly type 1 diabetes mellitus (4.9%), microscopic colitis (4.9%), and immune mediated-thyroid disease (4.1%). Celiac patients who also had immune-mediated diseases were significantly older at the time of diagnosis, compared to those without (P=0.002).

A total of 53 patients (12.9%) had malignancies, eight of whom suffered from Enteropathy Associated T-cell Lymphomas.

This is the first Dutch study to describe a group of celiac patients in such detail. The study highlights the wide range of clinical variables in celiac disease, as well as the importance of screening for celiac patients for concomitant diseases.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


We made these in my Jr. High Home Ec class back in the early 1970s and I still bake them today! Yum!

1 cup of peanut butter, 1 cup of sugar, an egg, vanilla. Top with sea salt, chocolate, nuts, whatever and bake for like 10 minutes. Let them air dry for a day or two (if you want a more cookie-like mouthfeel and texture) Not the healthiest, but its refreshing to have a baked good without arcane...

Already had the displeasure of going out for Chinese/Sushi with friends and navigating the veritable minefield that was the menu. Unless I find a trustworthy chef I think I would stick strictly to nigiri and sashimi-not that I can complain about that. As soon as I get tamari I am going to start c...

One of my favorite taquerias serves some of the tastiest grilled scallions I've ever had. This recipe brings those winning flavors to the grill. Roasted scallions make a delightful side dish. View the full article

My daughter has had SIBO. The gas and belching and bloating were terrible. Probiotics DID NOT help. They made her worse. The standard antibiotics only temporarily helped. Diet change (SIBO Specific Diet - really reduced fermentable carbs), two months of different herbal antibiotics, daily Atran...