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Thiamine

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knitty kitty

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Some interesting articles about Thiamine



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Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: the Involvement of CCL2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135011/

 

Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102562/

 

Celiac Disease: A Disorder Emerging from Antiquity, Its Evolving Classification and Risk, and Potential New Treatment Paradigms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282854/

 

Potato Glycoalkaloids Adversely Affect Intestinal Permeability and Aggravate Inflammatory Bowel Disease

https://pubmed.ncbi.nlm.nih.gov/12479649/

 

What to Eat (and Not Eat) to Reverse Autoimmune Disease

https://www.amymyersmd.com/2018/04/eat-not-eat-reverse-autoimmune-disease/

 

11 Silent Signs of a Thiamine Deficiency

https://www.rd.com/health/conditions/silent-signs-thiamine-deficiency/

 

Thiamine Prescribing Practices for Adult Patients Admitted to an Internal Medicine Service

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491193/

 

Clinical and Subclinical Thiamine Deficiency in Clinical Practice

https://pubmed.ncbi.nlm.nih.gov/4042079/

 

High-dose Thiamine Improves Fatigue After Stroke: A Report of Three Cases

https://pubmed.ncbi.nlm.nih.gov/25192035/

 

Vitamin B1 deficiency in patients with postural tachycardia syndrome (POTS)

https://www.researchgate.net/publication/317077809_Vitamin_B1_deficiency_in_patients_with_postural_tachycardia_syndrome_POTS

Prevalence of Thiamine (B1) deficiency in a cohort diagnosed with Postural Orthostatic Tachycardia (POTS)

https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.871.3

The Response to Treatment of Subclinical Thiamine Deficiency in the Elderly

https://pubmed.ncbi.nlm.nih.gov/9322569/

Neurological manifestations, diagnosis, and treatment of celiac disease: A comprehensive review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829244/

 

The Effects of Vitamin B1 on Ameliorating the Premenstrual Syndrome Symptoms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825494/

 

Subclinical Thiamine Deficiency Identified by Preoperative Evaluation in an Ovarian Cancer Patient: Diagnosis and the Need for Preoperative Thiamine Measurement

https://pubmed.ncbi.nlm.nih.gov/30168403/

Subclinical Thiamine Deficiency in Patients With Abdominal Cancer

https://pubmed.ncbi.nlm.nih.gov/29277168/

Thiamine and Heart Failure

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543258/

Elevated Lactate Secondary to Gastrointestinal Beriberi

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699997/

Acute Bilateral Deafness as the First Symptom of Wernicke Encephalopathy

http://www.ajnr.org/content/33/3/E44

 

Thiamine and Hashimoto's Thyroiditis: A Report of Three Cases

https://pubmed.ncbi.nlm.nih.gov/24351023/

 

Shoshin Beriberi in Critically-Ill patients: case series

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443551/

 

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/#idm140604396876032title

 

Nonalcoholic Thiamine-Related Encephalopathy (Wernicke-Korsakoff Syndrome) Among Inpatients With Cancer: A Series of 18 Cases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979979/

 

A systematic review of the role of vitamin insufficiencies and supplementation in COPD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016352/

 

Achlorhydria is associated with thiamine deficiency in the setting of bacterial overgrowth.

https://emedicine.medscape.com/article/170066-medication

 

Vitamin B1 Deficiency in Patients With Postural Tachycardia Syndrome (POTS)

https://pubmed.ncbi.nlm.nih.gov/28531358/

 

Recurrent Wernicke's Encephalopathy in a 16-Year-Old Girl with Atypical Clinical and Radiological Features

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970335/

 

A systematic review of the role of vitamin insufficiencies and supplementation in COPD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016352/

 

Thiamin Deficiency and Heart Failure: The Current Knowledge and Gaps in Literature

https://pubmed.ncbi.nlm.nih.gov/24811895/

 

Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature

https://pubmed.ncbi.nlm.nih.gov/23910704/

 

Thiamine and Heart Failure

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543258/

 

Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache

https://pubmed.ncbi.nlm.nih.gov/29850313/

 

 

 

 

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To All,

No discussion on Thiamine is complete without considering which Thiamine Supplements are the best absorbed by the body. See this Hormones Matter article about choosing which Thiamine Supplement is best for you.

https://www.hormonesmatter.com/navigating-thiamine-supplements/    

The hardest thing about  Vitamin supplements  is finding one that has  high bioavailability....
The ones with common shelf availablity often are the ones which the least absorbabiilty....even in good quality "Supplements" the less expensive and more common Thiamin (HCL) and/or Thiamine Monontriate  is the one(s) most commonly found in thiamine  supplements/B-Complex's...because they have long shelf life...but poor bioavailabilty

See this research article on how much better absorbed is the fat soluble Benfotiamine form found in the diabetic section...

https://www.researchgate.net/publication/259627300_Pharmacokinetic_Study_of_Benfotiamine_and_the_Bioavailability_Assessment_Compared_to_Thiamine_Hydrochloride

(This is true for Magnesium supplements too) see below in a minute...

I have recommended the Benfotiamine fat soluble form because it is readily avaible at most Vitamin stores....there is also Allithiamine but is hard to find (see hormones matter article about this form)
The 2nd hardest thing is understanding the need for the Vitamin Co-factor to allow/spark Vitamin bio-availability to the body....

For Thiamine that is Magnesium...Magnesium and Thiamine are Team Mates for Energy in the body....get low in either one and your energy levels will drain down... See these two links that explain it well...

https://www.wellnessresources.com/news/magnesium-and-vitamin-b1-team-players-needed-for-brain-muscles-metabolism

https://www.ncbi.nlm.nih.gov/pubmed/4050546

But you need again to find a high quality form that has high bio-availability...

Oxides are commonly available....but again like Thiamine Mononitrate has long shelf life but low Bio-Availability ......find a Magnessium Citrate with meals....or Magnesium Glycinate anytime and it will help you.

Thiamine and Magnesium work synergistically in the body....and are best taken together like Calcium and Vitamin D etc...

If you don't' notice a great improvement in 3 to 4 weeks of taking Benfotiamine then add Magnesium Citrate (with Meals) to your regimen and you will notice a substantial boost in your energy levels and probably Lucid dreams....if your stomach acid is not too low to absorb them.

Most people notice an improvement after 3 to 4 weeks of taking B-Vitamins a couple times a day and a sustained improvement after 3 to 4 months....a 2nd option would be to take a B-complex like a B-50 2/day and add Benfotiamine to your regimen with the above mentioned Magnesium Glycinate....but then you won't know which B-Vitamin helped you....B-Complexs work synergistically.....and this way you would be taking a high quality fat soluble B1 form of Thiamine plus have the benefit of all the other B-Vitamins too!

Magnesium almost magically makes people dream....Thiamine might causing dreaming too if you are absorbing it....but if you are too low in Magnesium your body can't convert Thiamine into an  active form in the body.

I hope this is helpful but it is not medical advise.

Posterboy,

Not sure why links are not activating but right click on path and you can open them in another tab/page.

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something to add. if you drink a lot of energy drinks you may not notice the same b deficiencies as others because energy drinks tend to only have b12 niacin and riboflavin. so you'll be getting plenty of niacin but no thiamine, folate, or biotin at all

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