Celiac Disease Antibodies Correlate with Psoriasis Activity

Br J Dermatol. 2004 Oct;151(4):891-4

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Celiac.com 11/09/2004 – A study carried out by Irish researchers to determine whether there is an association between celiac disease antibodies and psoriasis activity found that the presence of Antigliadin antibodies (AGA) did increase the severity of the disease. The researchers looked at 130 patients with psoriasis and screened them for serum IgG and IgA AGA, IgA antitransglutaminase and IgA antiendomysial antibodies. The patients were invited to undertake an endoscopy with duodenal biopsy. They found that a significantly higher proportion of psoriasis patients had elevated celiac disease associated antibody levels, and those with elevated antibodies had previously required systemic immunosuppressants or psoralen plus ultraviolet A phototherapy. Out of the 130 patients one new case of celiac disease was diagnosed. The researchers conclude that the presence of celiac disease associated antibodies in psoriasis patients correlates with greater psoriasis activity.