Hla Dqa/dqb Testing - Please Help Me

[stefanie1976]

Hi All,

I was tested last week, and my results came back as follows:

HLA DQ alleles detected: DQA1*02:01, 03:MN

                                          DQB1*02:YE, 03:ABXNG

 

DQ2      DQA1*05:01/05:05 negative

              DQB1*02:01/02:02 positive, one copy

 

DQ8      DQA1*03:XX positive, one copy

              DQB1*03:02 positive, one copy

           

 

Could anyone please help me understand these?

I know very little about genetics in general... so please bear with me ;-)

 

Thank you,
Stefanie

[cyclinglady]

You have a few positives (but I never had genetic tests and therefore have not really studied up in them), but a positive just means you are in the same club as about 30% of the population that has a 1% chance of developing celiac disease. These tests usually help rule out celiac disease. A celiac blood panel testing for antibodies is used to diagnosed celiac disease along with an intestinal biopsy (usually).

Did you get antibody blood testing?

[stefanie1976]

You have a few positives (but I never had genetic tests and therefore have not really studied up in them), but a positive just means you are in the same club as about 30% of the population that has a 1% chance of developing celiac disease. These tests usually help rule out celiac disease. A celiac blood panel testing for antibodies is used to diagnosed celiac disease along with an intestinal biopsy (usually).

Did you get antibody blood testing?

Hi Cyclinglady,

I love cycling, too ;-)

Thank you for your reply.

I was tested for antibodies, but none of them positive.

A biopsy has not been done, yet, but my doc hinted at it last time (I will see him again in 10 days).

 

Stefanie

[cyclinglady]

Here is the complete panel:

-tTG IgA and tTG IgG

-DGP IgA and DGP IgG

-EMA IgA

-total serum IgA and IgG (control test)

-AGA IGA and AGA IgG - older and less reliable tests largely replaced by the DGP

-endoscopic biopsy - make sure at least 6 samples are taken

(Source: NVSMOM -- )

Often due to insurance reasons (saving money), doctors order a celiac screening which normally just includes the ttg and checking for an Iga deficiency. That is okay for most, but in my case I only had one positive --the DGP iga. Good thing my doctor ordered the entire panel! I ended up with moderate to severe intestinal damage.

So, check your lab copies!

[stefanie1976]

Thank you again. I checked, and I only had tTG done. Maybe I will either ask for complete panel, or proper biopsy (I have to have an endoscopy anyways, so they may just as well...)

Stefanie