Help interpreting test results

[Tara90]

Hi, 

I have received my blood test results back and would appreciate some assistance in interpreting them. My GP admitted she has limited knowledge/experience with coeliac disease and has referred me to a gastroenterologist for opinion, but I would like to have a bit more of an understanding of what my results mean before going into that appointment. 

Serology:  (NB: The reference range for all of the below is <15)

Deamidated Gliadin IgA: 1 U/ml

Deamidated Gliadin IgG: 39 U/mL 

Tissue Transglutaminase IgA <1 U/mL

Tissue Transglutaminase IgG <1 U/mL

It also states on the serology report that "if selective IgA deficiency is detected (<0.07g/L) which would render IgA-based serology non-informative this is also reported). I can't see anything in the results about this, so assume that I have not tested as IgA deficient. 

Gene Test:

"Hereterozygous for the haplotype, which is consistent with the DQ2 phenotype". 

From my limited knowledge and Google research it seems that TTG is the more sensitive and specific test for coeliac disease, whereas DGP IgG is most useful in the instance of IgA deficiency. Given that I have tested negatively for TTG and don't have IgA deficiency is it possible that the DGP is a false negative? I have no nausea/diarrhoea/bloating/etc, but do suffer from Chronic Fatigue Syndrome and also have chronic constipation and a lot of headaches. I've also been diagnosed with osteoporosis in my hips and lumbar spine (I'm 27 y.o), although my doc believes this is due to my past history of anorexia nervosa. 

I would appreciate any insights. Thanks.  

Edit: I should add that I have had the serology panel done 3 times now and the results were virtually identical each time. 

[cyclinglady]

6 hours ago, Tara90 said:

Hi, 

I have received my blood test results back and would appreciate some assistance in interpreting them. My GP admitted she has limited knowledge/experience with coeliac disease and has referred me to a gastroenterologist for opinion, but I would like to have a bit more of an understanding of what my results mean before going into that appointment. 

Serology:  (NB: The reference range for all of the below is <15)

Deamidated Gliadin IgA: 1 U/ml

Deamidated Gliadin IgG: 39 U/mL 

Tissue Transglutaminase IgA <1 U/mL

Tissue Transglutaminase IgG <1 U/mL

It also states on the serology report that "if selective IgA deficiency is detected (<0.07g/L) which would render IgA-based serology non-informative this is also reported). I can't see anything in the results about this, so assume that I have not tested as IgA deficient. 

Gene Test:

"Hereterozygous for the haplotype, which is consistent with the DQ2 phenotype". 

From my limited knowledge and Google research it seems that TTG is the more sensitive and specific test for coeliac disease, whereas DGP IgG is most useful in the instance of IgA deficiency. Given that I have tested negatively for TTG and don't have IgA deficiency is it possible that the DGP is a false negative? I have no nausea/diarrhoea/bloating/etc, but do suffer from Chronic Fatigue Syndrome and also have chronic constipation and a lot of headaches. I've also been diagnosed with osteoporosis in my hips and lumbar spine (I'm 27 y.o), although my doc believes this is due to my past history of anorexia nervosa. 

I would appreciate any insights. Thanks.  

Edit: I should add that I have had the serology panel done 3 times now and the results were virtually identical each time. 

Your result is unusual, but your GP was correct in referring you to a GI.  Like you, I tested positive on only the DGP.  In my case, it was the IgA version.  All others in the panel have always been negative even in follow-up testing.  

The TTG is very good and catches MOST celiacs.  It is typically used as a screening test in order to save  costs and the fact it is very good.  But it did not catch you!  

Not all celiacs have the traditional GI symptoms.  Some even have zero symptoms.  When I was diagnosed, I just had anemia.  I even had a genetic anemia which masked my iron-deficiency anemia (that particular anemia was blamed on my monthly cycle which was totally incorrect).  Two months later, I fracture my back doing nothing.  My diagnosis was shocking (I had moderate to severe intestinal damage).  

Talk to your new GI.  Consider the endoscopy since you have so many issues.   This might be the answer!  

Take care and keep researching.   Your health is important!  

 

[Tara90]

Thanks for the advice Cyclinglady. That's really helpful info. I have also been diagnosed with anaemia of chronic disease (low haemoglobin but not caused by iron deficiency), which my haematologist believes is likely a result of bone marrow suppression due to my past anorexia. I wonder if it could actually be related to a gluten issue?

Does anyone else have any thoughts?

[cyclinglady]

1 hour ago, Tara90 said:

Thanks for the advice Cyclinglady. That's really helpful info. I have also been diagnosed with anaemia of chronic disease (low haemoglobin but not caused by iron deficiency), which my haematologist believes is likely a result of bone marrow suppression due to my past anorexia. I wonder if it could actually be related to a gluten issue?

Does anyone else have any thoughts?

Yes.  Learn more:

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and....celiac disease can be considered as a chronic illness.  Seems like your hematologist can not get past your past anorexia diagnosis (and I am not discounting the impact anorexia may have had on your anemia or any other damage incurred).   It could be a combination of many of things.

Discuss this with your GI.