Low TTG IGA but high TTG IGG

[Cal4802]

Hi, 

Does anyone have any experience with having a low TTG IGA test (but not "deficient")... 1.. Over 4 was positive on scale they used... But my TTG IGG was really high (10...anything over 6 was "positive"). 

 

My understanding is TTG IGA is the more accurate of the two tests but I'm wondering why my TTG IGG would be so high. My physician told me to assume I have celiac and act like I do to play it safe because the IGG was so high and without an endoscopy of small intestine could never know for sure but safe to say.. I've been doing this for a year now and feel better, I think? Just curious if others have the same results..? 

[cyclinglady]

Try using the search box located at the top.  Lots of members have discussed this.   Just type in TTG IgG.  

I am sorry that you are doubting your diagnosis.  The blood tests are pretty good, but most celiac disease specialists like take a look inside your small intestine.  An endoscopy is still the gold standard in diagnosing celiac disease.

You have been gluten-free for a year.  Has your doctor re-checked to see if the TTG IgG came down?  That would be a place to start.  

[Cal4802]

4 minutes ago, cyclinglady said:

Try using the search box located at the top.  Lots of members have discussed this.   Just type in TTG IgG.  

I am sorry that you are doubting your diagnosis.  The blood tests are pretty good, but most celiac disease specialists like take a look inside your small intestine.  An endoscopy is still the gold standard in diagnosing celiac disease.

You have been gluten-free for a year.  Has your doctor re-checked to see if the TTG IgG came down?  That would be a place to start.  

Thanks. Yes I've read through a lot of the other posts on the topic but nothing seems super clear. I just got retested actually so we'll see how those results come back. 

[cyclinglady]

It is an unclear result.  It is not common.  Did you get tested for an IgA (Immunoglobulin A) deficiency?   This happens to about 5 to 10 % of celiacs and in the case of celiac disease testing means the IgA type tests will not work.  It is why the IgG tests are offered.  

Personally, I test positive to only the DGP IgA even in many follow-up tests, yet I had some severe intestinal damage.  I also had some risk factors like Hashimoto’s Thyroiditis and iron-deficiency anemia.  

[Cal4802]

5 minutes ago, cyclinglady said:

It is an unclear result.  It is not common.  Did you get tested for an IgA (Immunoglobulin A) deficiency?   This happens to about 5 to 10 % of celiacs and in the case of celiac disease testing means the IgA type tests will not work.  It is why the IgG tests are offered.  

Personally, I test positive to only the DGP IgA even in many follow-up tests, yet I had some severe intestinal damage.  I also had some risk factors like Hashimoto’s Thyroiditis and iron-deficiency anemia.  

Interesting.. Yes they did test for IGA and it was "5" (20 or higher was "positive") but pretty sure I asked and they said I didn't have a "deficiency". So I guess I'm just like a lot of people who seem to have a high IGG but not IGA... Which might be gluten sensitivity or celiac? Probably is per my practitioner but again other things I read says who knows... 

[cyclinglady]

While I have  a firm diagnosis, my hubby does not.  He went gluten-free 12 years before me per the advice of his GP and my allergist.  The diet worked.  It is obvious to everyone that gluten makes him sick.  He refuses to do a gluten challenge.  

I guess I am trying to say that if you feel good on the diet, then stick with it.  If you are not getting family support or you are still ill, you should consult with a GI who is celiac savvy.