Pseudo Gout of the knees vs celiac

[NickL]

I have had three episodes of pseudo Gout in my knees, with in last year. I have only one kidney due to a donation and otherwise healthy 65 year old. curious regarding others who have been Diagnosed with Celiac and have any association with Chondrocalcinosis/ Hyperparathyroidism issues. Should there be specific Labs being drawn yearly to detect or maintain a stable nutritional course. Thanks stay well 

[Fenrir]

There is a correlation between celiac disease and gout:
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703914/

Celiacs seem to have higher uric acid levels than those that don't which may be part of the reason many celiacs have terrible joint issues/arthritis. 

Same with hypothyroid:
https://www.amjmed.com/article/S0002-9343(17)30822-7/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726817/

I'm no doctor but Vitamin D, Calcium, Uric Acid and celiac antibodies (if you are having any possible symptoms) would be appropriate, IMO. 

 

[knitty kitty]

On 3/6/2020 at 8:40 AM, NickL said:

I have had three episodes of pseudo Gout in my knees, with in last year. I have only one kidney due to a donation and otherwise healthy 65 year old. curious regarding others who have been Diagnosed with Celiac and have any association with Chondrocalcinosis/ Hyperparathyroidism issues. Should there be specific Labs being drawn yearly to detect or maintain a stable nutritional course. Thanks stay well 

I was curious about your question, and researched a little.  I'm not a doctor. This isn't medical advice.  You may want to talk to your doctor.  

Gout is caused by high levels of uric acid.  Lactic acid has precedence to be cleared by the body first. High levels of lactic acid are caused by thiamine deficiency.

Here's the study that found lactic acid gets cleared first....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441887/?page=6

 

Thiamine deficiency causes a build up of lactic acid......

Severe lactic acidosis reversed by thiamine within 24 hours

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388689/

 

And Dr. Lonsdale studies thiamine deficiency in gout of this patient...

https://books.google.com/books?id=DLpvDgAAQBAJ&pg=PA119&lpg=PA119&dq=uric+acid+hyperuricemia+and+thiamine+deficiency&source=bl&ots=92lovo914F&sig=ACfU3U20uDcMJX2VVMtk5QX_OFy1PQzgBQ&hl=en&sa=X&ved=2ahUKEwi5jvfD2YfpAhUQ7awKHS5pAAoQ6AEwEXoECAUQAQ#v=onepage&q=uric acid hyperuricemia and thiamine deficiency&f=false

 

This article

https://www.google.com/url?sa=t&source=web&rct=j&url=https://pdfs.semanticscholar.org/fd8f/df22cd36353f5e3445bf35084c5b1771bd7a.pdf&ved=2ahUKEwir9O_R34fpAhUE1qwKHXTWDXIQFjAAegQIAhAB&usg=AOvVaw0q6gFlLhjosUdcVejPB3kR

Semantic Scholar ›
The multifaceted and widespread pathology of magnesium deficiency - Semantic Scholar

Magnesium deficiency precipitates pseudo gout.....Thiamine needs magnesium to work properly.

And another...

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.amjmed.com/article/S0002-9343(99)00175-8/pdf&ved=2ahUKEwih497b4YfpAhVFXK0KHYAnAeAQFjAAegQIAxAB&usg=AOvVaw1mMXxOAfjrJ7vcGJwFUaeN

AMJMED.com › 
hypomagnesemia and chondrocalcinosis in gitelman syndrome - American Journal of Medicine

And this article is interesting...

Celiacs often have Small Intestinal Bacterial Overgrowth....

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757479/#!po=13.5417

So...maybe you should ask your physician to check you for magnesium and thiamine deficiencies and test you for SIBO...

Talk to your doctor. This is not medical advice.  I'm just a curious kitten....

 

Edited April 27, 2020 by knitty kitty
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[NickL]

4 minutes ago, knitty kitty said:

I was curious about your question, and researched a little.  I'm not a doctor. This isn't medical advice.  You may want to talk to your doctor.  

Gout is caused by high levels of uric acid.  Lactic acid has precedence to be cleared by the body first. High levels of lactic acid are caused by thiamine deficiency.

Here's the study that found lactic acid gets cleared first....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441887/?page=6

 

Thiamine deficiency causes a build up of lactic acid......

Severe lactic acidosis reversed by thiamine within 24 hours

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388689/

 

And Dr. Lonsdale studies thiamine deficiency in gout of this patient...

https://books.google.com/books?id=DLpvDgAAQBAJ&pg=PA119&lpg=PA119&dq=uric+acid+hyperuricemia+and+thiamine+deficiency&source=bl&ots=92lovo914F&sig=ACfU3U20uDcMJX2VVMtk5QX_OFy1PQzgBQ&hl=en&sa=X&ved=2ahUKEwi5jvfD2YfpAhUQ7awKHS5pAAoQ6AEwEXoECAUQAQ#v=onepage&q=uric acid hyperuricemia and thiamine deficiency&f=false

 

This article

https://www.google.com/url?sa=t&source=web&rct=j&url=https://pdfs.semanticscholar.org/fd8f/df22cd36353f5e3445bf35084c5b1771bd7a.pdf&ved=2ahUKEwir9O_R34fpAhUE1qwKHXTWDXIQFjAAegQIAhAB&usg=AOvVaw0q6gFlLhjosUdcVejPB3kR

Semantic Scholar ›
The multifaceted and widespread pathology of magnesium deficiency - Semantic Scholar

Magnesium deficiency precipitates pseudo gout.....Thiamine needs magnesium to work properly.

And another...

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.amjmed.com/article/S0002-9343(99)00175-8/pdf&ved=2ahUKEwih497b4YfpAhVFXK0KHYAnAeAQFjAAegQIAxAB&usg=AOvVaw1mMXxOAfjrJ7vcGJwFUaeN

AMJMED.com › 
hypomagnesemia and chondrocalcinosis in gitelman syndrome - American Journal of Medicine

And this article is interesting...

Celiacs often have Small Intestinal Bacterial Overgrowth....

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757479/#!po=13.5417

So...maybe you should ask your physician to check you for magnesium and thiamine deficiencies and test you for SIBO...

Talk to your doctor. This is not medical advice.  I'm just a curious kitten....

 

 

4 minutes ago, knitty kitty said:

I was curious about your question, and researched a little.  I'm not a doctor. This isn't medical advice.  You may want to talk to your doctor.  

Gout is caused by high levels of uric acid.  Lactic acid has precedence to be cleared by the body first. High levels of lactic acid are caused by thiamine deficiency.

Here's the study that found lactic acid gets cleared first....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441887/?page=6

 

Thiamine deficiency causes a build up of lactic acid......

Severe lactic acidosis reversed by thiamine within 24 hours

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388689/

 

And Dr. Lonsdale studies thiamine deficiency in gout of this patient...

https://books.google.com/books?id=DLpvDgAAQBAJ&pg=PA119&lpg=PA119&dq=uric+acid+hyperuricemia+and+thiamine+deficiency&source=bl&ots=92lovo914F&sig=ACfU3U20uDcMJX2VVMtk5QX_OFy1PQzgBQ&hl=en&sa=X&ved=2ahUKEwi5jvfD2YfpAhUQ7awKHS5pAAoQ6AEwEXoECAUQAQ#v=onepage&q=uric acid hyperuricemia and thiamine deficiency&f=false

 

This article

https://www.google.com/url?sa=t&source=web&rct=j&url=https://pdfs.semanticscholar.org/fd8f/df22cd36353f5e3445bf35084c5b1771bd7a.pdf&ved=2ahUKEwir9O_R34fpAhUE1qwKHXTWDXIQFjAAegQIAhAB&usg=AOvVaw0q6gFlLhjosUdcVejPB3kR

Semantic Scholar ›
The multifaceted and widespread pathology of magnesium deficiency - Semantic Scholar

Magnesium deficiency precipitates pseudo gout.....Thiamine needs magnesium to work properly.

And another...

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.amjmed.com/article/S0002-9343(99)00175-8/pdf&ved=2ahUKEwih497b4YfpAhVFXK0KHYAnAeAQFjAAegQIAxAB&usg=AOvVaw1mMXxOAfjrJ7vcGJwFUaeN

AMJMED.com › 
hypomagnesemia and chondrocalcinosis in gitelman syndrome - American Journal of Medicine

And this article is interesting...

Celiacs often have Small Intestinal Bacterial Overgrowth....

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757479/#!po=13.5417

So...maybe you should ask your physician to check you for magnesium and thiamine deficiencies and test you for SIBO...

Talk to your doctor. This is not medical advice.  I'm just a curious kitten....

 

Thank you for the reply and I will take a look at these articles this is interesting, thanks again stay well. 

Thank you very much