Role of B-Vitamins and Magneisum for Supportive Care in Patients with COVID-19

[Posterboy]

To All,

I just wanted to start a thread so these research articles on B-Complex and Magnesium for support care in COVID-19 patients  is in one thread and easier to find if some one wanted to research them some more.

See this entitled "Be well: A potential role for vitamin B in COVID-19"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428453/

And two on Magnesium for supportive care for COVID-109 patients.

Entitled "The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives"

https://pubmed.ncbi.nlm.nih.gov/32554340/

And the second one Magnesium

Entitled "Possibility of Magnesium supplementation for supportive treatment in patients with COVID-19"

https://pubmed.ncbi.nlm.nih.gov/32931782/

I hope this is helpful but it is not medical advice.

Posterboy,

[Scott Adams]

As usual, very interesting research. I've been taking both, so hopefully their research is correct!

[Posterboy]

23 hours ago, Scott Adams said:

As usual, very interesting research. I've been taking both, so hopefully their research is correct!

Scott, You know my vote!

Poor Nutrition is the key to many diseases but we don't see it with our "eyes" if comes from HIGH Calorie Malnutrition.

This is about the Magnesium connections to disease and it's regulation of IL-2 important in a Celiac disease diagnosis.

It is known as an X-MEN genetic disease but this condition is reversed when we take Magnesium!

https://medlineplus.gov/genetics/condition/x-linked-immunodeficiency-with-magnesium-defect-epstein-barr-virus-infection-and-neoplasia/#synonyms

It is how the Epstein Barr Virus (aka EBV) gets into our Cells....we get low in Magnesium FIRST.

See this research that shows how Magnesium levels are low in those who have been infected with EBV.

Entitled "PLASMA MAGNESIUM IS INVERSELY ASSOCIATED WITH EPSTEIN-BARR VIRUS LOAD IN PERIPHERAL BLOOD AND BURKITT LYMPHOMA IN UGANDA"

I didn't capitalize the title....it is that way in the research...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785547/

Indicating the way I read it that Burkitt's Lymphoma can be triggered by EBV triggered by being low in Magnesium!

This is important because Magnesium helps IL-2 (aka as a cytokine) in the body which is important in Celiac disease.

See this research

Entitled "Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase"

https://pubmed.ncbi.nlm.nih.gov/31507602/

where they note quoting

"Supplemental magnesium in patients with mutations in another protein important for T cell signaling, MAGT1, was reported to restore EBV-specific cytotoxicity. Our findings highlight the critical role of ITK for T cell activation and suggest the potential for supplemental magnesium to treat patients with ITK deficiency."

Now back to the role of IL-2 again aka cytokine in Celiac's.

It was reported on Celiac.com and I started a thread about it....but nobody seemed to notice at the time...

quoting from the Celiac.com article on Cytokines triggering gut reactions in Celiac disease...

"Patients receiving gluten by injection showed at least 15 elevated plasma cytokines, with IL-2, IL-8, and IL-10 being most common, with changes 272-fold (of IL-2), 11-fold, and 1.2-fold, respectively. IL-2 and IL-8 were the only cytokines elevated at 2 hours, prior to symptom onset."

I came across this research on Riboflavin aka Vitamin B2 and started a thread on it....

But no body seemed to notice it or understand it....B-Vitamins deficiencies like Riboflavin and Magnesium are regulating Cytokine production leading to a Celiac diagnosis IMHO.

Best illustrated in my mind in this study showing  how B-Vitamins like B1, B2 and B3 works synergistically to regulate first inflammation, then sepsis and finally toxicity in the body....and this happens when get too STRESSED out of our B-Vitamins triggering disease.....

See this research entitled "Vitamin B combination reduces fluconazole toxicity in Wistar rats"

https://pubmed.ncbi.nlm.nih.gov/30903555/

I have tried to point people in the right direction.....other than  Knitty Kitty@knitty kitty who gets the Thiamine link...nobody seems to get it....

I explained here if you haven't read it yet...or in case some one happens on this thread for some reason....they won't  have to search for it again...

Poor Nutrition triggers genetically susceptible diseases...

This happens with a lot of diseases most notably in my mind is the "MTHFR Gene defect/variant' not from B12 but from B-2.

Explained better here  by Chris Masterjohn than I can explain it.

https://chrismasterjohnphd.com/blog/2019/02/26/mthfr-just-riboflavin-deficiency/

When our Vitamin transporters for Magnesium, Thiamine, Riboflavin, Niacin etc. get broken from low Vitamin/Mineral status genetic disease are named after them....

But like in the above research on Burkitt's Lymphoma and the Epstein Bar Virus they/it can reversed with adequate supplementation!

Proving it is not a genetic disease 100% of the time but a 50/50 Epigenetic condition where the Vitamin/Mineral Deficiency leads to the genetic disease diagnosis treated with Supplementation!

The problem is most of the time we don't know which Vitamin/Mineral to take in the FIRST place!

And we never discover how to reverse "the genetic condition" triggered by poor nutrition....IMO!

See this extreme example of what happens when we get too low in Riboflavin...

https://www.jstage.jst.go.jp/article/internalmedicine/50/21/50_21_2663/_pdf/-char/en

And this one showing how Neurogenerative diseases can respond to Riboflavin treatment....similar to the way Wernicke's Encephalopathy responds to Thiamine supplementation confirming in IMO undiagnosed Beri Beri....in many people going diagnosed as a genetic disease instead!

Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447943/

And the research on Riboflavin and Magnesium affecting Cytokine production of IL-2 then IMHO supplementation can and should be used for supportive/therapeutic care in Celiacs.

The recent research on Tryptophan bears out these same findings.

https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx

I hope this is helpful but it is not medical advice.

Posterboy,

[Scott Adams]

I agree that nutritional deficiencies could be an environmental trigger of celiac disease in susceptible individuals with the genetic markers for celiac disease. It may also explain non-celiac gluten sensitivity which is now recognized as a different condition. However it is unclear whether correcting the nutritional deficiencies could reverse either condition, which I highly doubt.

[Posterboy]

Scott and Knitty Kitty,

Here is the research that summarizes how Enzymatic pathways break down when Vitamins are low....leading in time to a genetic diagnosis.

As Knitty Kitty says you have to "Saturate" the (Vitamin) channel....thus reversing the deficiency and restoring the Enzymatic pathway.

This research is a little old....so if @knitty kittycan find a more up to date version of this study I would be interested in reading it....but it does establish how Vitamin deficiencies are being diagnosed as genetic disease(s)....when the Vitamins enzymatic pathway or co-factors become low then the vitamin deficiency triggers a genetic diagnosis.

Entitled "High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms"

https://academic.oup.com/ajcn/article/75/4/616/4689367

Read only the abstract it is quite long.....I could only scan it...IT is definitely TL:DR ....but the abstract establishes the relationship between Vitamin deficiencies first then genetic disease diagnosis later...

Reversed by High Dose Vitamin supplementation.

What struck by the article is just  how many Vitamin deficiencies are being diagnosed and treated as "Genetic diseases" subsequently treated with High Doses of Vitamins instead...nearly fifty and this particular study is almost twenty years old....they have probably found more of these Vitamin deficient triggered genetic diseases....since then....if anybody knew to look for them!

quoting from the abstract....

"About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, which at least partially restores enzymatic activity. Several single-nucleotide polymorphisms, in which the variant amino acid reduces coenzyme binding and thus enzymatic activity, are likely to be remediable by raising cellular concentrations of the cofactor through high-dose vitamin therapy."

We see this in Wernicke's Encephalopathy.....where a Vitamins co-factor (Magnesium) leads to Secondary deficiency of Thiamine treated by the Primary deficiency of Magnesium...

Entitled "Wernicke's encephalopathy induced by magnesium depletion"

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)00182-8/fulltext#:~:text=Many cases of Wernicke's encephalopathy may also have,lead to Mg depletion%3B Magnesium in clinical practice

And why Magnesium should always be taken with Thiamine for best results....

Is Wernicke's Encephalopathy first a Magnesium deficiency or is it first a Thiamine deficiency?

The Co-factor unlocks the door to health....

We get first low in Magnesium.....then Thiamine....and low Thiamine levels thin our Villi...

Here is the original research on Low Thiamine levels thinning animals Villi...

Entitled "Effect of dietary thiamine deficiency on intestinal functions in rats"

https://pubmed.ncbi.nlm.nih.gov/6465054/

It should also be noted the common Mineral deficiency of Iron Deficiency Anemia can be explained 1) by Low Stomach and 2) by Low B-Vitamins like (Riboflavin and Niacin) but also now proven to trigger low Iron in those low in Thiamine...

Here is the Niacin link to Iron deficiency....as quoted by Blue Sky...

Entitled "Effect of nicotinic acid (aka Niacin or Vitamin B-3) on zinc and iron metabolism"

https://pubmed.ncbi.nlm.nih.gov/9353874/

I just found this research on Thiamine effects Iron absorption that seals the question for me...

Entitled "The Iron Deficiency Response of Corynebacterium glutamicum and a Link to Thiamine Biosynthesis"

https://pubmed.ncbi.nlm.nih.gov/32144105/

These common mineral deficiencies can be explained by being low in B-Vitamins first....but the Magnesium deficiency precedes the Thiamine deficiency.....

At that point the Thiamine deficiency triggers the Thin Villi in IMHO.

No wonder Iron deficiency anemia is common in Celiacs.....

They are low in the B-Vitamins that help the body absorb it!

I hope this is helpful but it is not medical advice.

Posterboy,