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High liver enzymes

Leslierose82

By Leslierose82
in Related Issues & Disorders

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Leslierose82 Newbie
Leslierose82
Posted

Why would liver be producing high enzymes? Was just diagnosed within past two months....kinda lost on why liver acting up.

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trents Grand Master
trents
Posted
(edited)
4 hours ago, Leslierose82 said:

Why would liver be producing high enzymes? Was just diagnosed within past two months....kinda lost on why liver acting up.

Elevated liver enzymes is one of recognized spinoffs of celiac disease. One expert has said it occurs in about 18% of the celiac population. It is what led to my celiac diagnosis about 20 years ago. There are different theories as to the mechanism. Some believe it is due to the "leaky gut" associated with celiac disease where larger than normal protein fractions leak across the gut into the blood, are detected as invaders or toxins that must be filtered by the liver but no one really knows for sure yet:

"The mechanism by which celiac disease patients develop abnormal liver enzymes remains unknown. Predisposition to autoimmunity and systemic effects of abnormal intestinal permeability are thought to play pathogenic roles.3 Gliadin induces an increase in gut permeability and MyD88-dependent zonulin release by binding to CXCR3 chemokine receptor.10,27 Zonulin is able to reversibly regulate intestinal permeability by modulation of intercellular tight junctions. It is thought that the increased intestinal permeability allows toxins, cytokines, and antigens to reach the liver through the portal circulation and cause liver injury through release of pro-inflammatory mediators. Toll-like receptors expressed in liver cells (such as Kupffer, endothelial, dendritic, hepatic stellate and hepatocytes) can recognize lipopolysaccharides (present in Gram-negative bacteria) and mount an immune response." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868701/

Edited by trents
Scott Adams Grand Master
Scott Adams
Posted

Also, this category contains articles that summarize recent research on liver issues and celiac disease:

https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/liver-disease-and-celiac-disease/ 

and we just published this one on Monday:

 

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