Any thoughts on my results over the years? I'm at a lose.

[kyle2265]

10 years ago I got tested for celiac disease because I was having a lot of IBS type symptoms since my late teens to early 20s. Below were the results.

tTG IgA : 24 U/mL Ref Range: 0 - 15
DGP IgA : 13 U/mL Ref Range: <=19
NOTE: <20 Units = Negative
NOTE: 20-30 Units = Weak Positive
NOTE: >30 Units = Postive

total IgA    309 mg/dL       Ref Range 69 - 309 mg/dL

Gastro said, yup you most likely have celiac so did a biopsy to confirm. Biopsy came back negative so he told me I don't have celiac. Fast forward 2 years we did the bloodwork again.

tTG IgA : 16 U/mL Ref Range: 0 - 15
DGP IgA : 14 U/mL Ref Range: <=19
NOTE: <20 Units = Negative
NOTE: 20-30 Units = Weak Positive
NOTE: >30 Units = Postive

total IgA    270 mg/dL       Ref Range 69 - 309 mg/dL

Gastro said bloodwork looks fine. Fast forward another 5 years and the bloodwork was done again and also another Endoscopy biopsy (The endo was to rule out another complaint but he did another celiac biopsy while he was there. Negative again.

total IgA    305 mg/dL       Ref Range 69 - 305 mg/dL

TTG IgA2.8 U/mL<7=Negative, 7-10=Equivocal, >10=Positive U/mL

Gliadin IgA2.8 U/mL<7=Negative, 7-10=Equivocal, >10=Positive U/mL

 

Based off all the labs and two negative biopsies, I'm sure it's fairly face to say I don't have celiac, correct? I've been diagnosed with (IBS) since the initial biopsy came back negative. Now (starting two years ago) I began having sensory nerve issues. Ended up getting a skin biopsy done and was told I have Idiopathic Small Fiber Neuropathy since all other tests that have done have came back normal. I'm wondering if gluten could still be the culprit. Any ideas?

[trents]

Yes. You could have NCGS (Non Celiac Gluten Sensitivity). It shares a lot of the same symptoms with celiac disease, including neurological problems, and is 10-12x more common than celiac disease. There currently is no way to test for NCGS but to first rule out celiac disease. The antidote is the same, namely, elimination of gluten from the diet for life.

Some celiac disease experts believe NCGS can be a precursor to celiac disease.

Edited May 9, 2022 by trents

[Scott Adams]

To me the fact that you had a positive tTG IgA twice before:

• tTG IgA : 16 U/mL Ref Range: 0 - 15
• tTG IgA : 24 U/mL Ref Range: 0 - 15

tells me that you likely have celiac disease, no matter what the biopsy results show.

If I were you I'd try a gluten-free diet and see if you get symptom relief. If so this would be further confirmation.

 

[kyle2265]

@trents and @Scott Adams - Thanks for the feedback. I started on a Gluten free diet two days ago now to give it a shot. Going to go for at least 3 months to see if it helps anything. Also, here is the results of my most recent Endoscopy in 2019. Interesting the "Fragments of antral and fundal mucosa with scant chronic inflammation"

A. Duodenum, biopsy:
–Essentially unremarkable small bowel mucosa.
–No dysplasia, infectious organisms, or celiac sprue identified.
 
B. Gastric biopsy:
–Fragments of antral and fundal mucosa with scant chronic inflammation.
–No active inflammation or atypia identified.

[trents]

Kyle, you need to read this. Going truly gluten-free is not as easy as most people think when they start the journey:

 

[kyle2265]

19 minutes ago, trents said:

Kyle, you need to read this. Going truly gluten-free is not as easy as most people think when they start the journey:

 

I'm actually starting with the AIP (Autoimmune protocol) diet. Really giving it my best shot over 90 days, then start adding some stuff back in (not gluten though, that will be the last thing just to see if I have any reactions). I'll give that a read for sure.