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IgG Negative, IgA Positive

CathWin
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CathWin Newbie
CathWin
Posted

Is Celiac a possibility with IgG negative? We went to the Dr. to try to identify the cause of stomach aches that are getting much better. They usually seem to be sugar related, so I was thinking a sugar enzyme deficiency. The Dr. added celiac screening to the bloodwork just in case. I was shocked to see that the Dr. wants my daughter to come in for an endoscopy to confirm celiacs. It is scheduled in a few days and my daughter is terrified. Since the results, all of my communication has been through online portal messaging. The nurse answers all of my questions and I can't get the answers I need. The Tissue Transglutaminiase IgG results were: IgG antibody value 13.84 negative (with negative range <20), IgA antibody value 113.38 positive (with positive range>30). IgA quantitative value 100. What I have read indicates that with a IgG negative, the chance of celiacs decreases and it might be something else. Is that right? On a side note, my daughter ate Panera Mac n cheese with baguette right before our appointment in the car. She was literally shoving the last bite of bread in her mouth as we walked in the door. Could this have caused a spike in results?

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trents Grand Master
trents
Posted

Is the IGA antibody test value of 113.38 a reference to the tTG-IGA test or total serum IGA? If it is the tTG-IGA then that is the first test ordered and the only test ordered (unfortunately) by many docs since it is the centerpiece of celiac antibody testing. It is considered to do the best job of combining both specificity with sensitivity. If that is the test you reference it is strongly positive.

And yes, you definitely can have celiac disease with a negative IGG. The IGG tests are more specific for celiac disease but less sensitive. So, they can miss it sometimes.

Can you post all the tests results exactly as they appear on the report? Some more information about exactly which IGA tests and which IGG tests were run. There are more than just one of each.

Here is a primer for antibody testing: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

What your daughter ate immediately before the testing would have no impact. The tests don't measure gluten levels, they measure inflammation levels in the lining of the small bowel in response to the consumption of gluten over time (months). 

Wheatwacked Veteran
Wheatwacked
Posted
1 hour ago, CathWin said:

What I have read indicates that with a IgG negative, the chance of celiacs decreases and it might be something else.

Misinformation. The industry would like us to believe because their profitability is at stake.

Scott Adams Grand Master
Scott Adams
Posted

Eating gluten before the tests is a good thing, and eating too little may make the test results invalid. Your daughter should keep eating gluten daily until all testing is completed.

Are those the only blood tests they did? 

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