Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

IgG Negative, IgA Positive


CathWin

Recommended Posts

CathWin Newbie

Is Celiac a possibility with IgG negative? We went to the Dr. to try to identify the cause of stomach aches that are getting much better. They usually seem to be sugar related, so I was thinking a sugar enzyme deficiency. The Dr. added celiac screening to the bloodwork just in case. I was shocked to see that the Dr. wants my daughter to come in for an endoscopy to confirm celiacs. It is scheduled in a few days and my daughter is terrified. Since the results, all of my communication has been through online portal messaging. The nurse answers all of my questions and I can't get the answers I need. The Tissue Transglutaminiase IgG results were: IgG antibody value 13.84 negative (with negative range <20), IgA antibody value 113.38 positive (with positive range>30). IgA quantitative value 100. What I have read indicates that with a IgG negative, the chance of celiacs decreases and it might be something else. Is that right? On a side note, my daughter ate Panera Mac n cheese with baguette right before our appointment in the car. She was literally shoving the last bite of bread in her mouth as we walked in the door. Could this have caused a spike in results?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



trents Grand Master

Is the IGA antibody test value of 113.38 a reference to the tTG-IGA test or total serum IGA? If it is the tTG-IGA then that is the first test ordered and the only test ordered (unfortunately) by many docs since it is the centerpiece of celiac antibody testing. It is considered to do the best job of combining both specificity with sensitivity. If that is the test you reference it is strongly positive.

And yes, you definitely can have celiac disease with a negative IGG. The IGG tests are more specific for celiac disease but less sensitive. So, they can miss it sometimes.

Can you post all the tests results exactly as they appear on the report? Some more information about exactly which IGA tests and which IGG tests were run. There are more than just one of each.

Here is a primer for antibody testing: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

What your daughter ate immediately before the testing would have no impact. The tests don't measure gluten levels, they measure inflammation levels in the lining of the small bowel in response to the consumption of gluten over time (months). 

Wheatwacked Veteran
1 hour ago, CathWin said:

What I have read indicates that with a IgG negative, the chance of celiacs decreases and it might be something else.

Misinformation. The industry would like us to believe because their profitability is at stake.

Scott Adams Grand Master

Eating gluten before the tests is a good thing, and eating too little may make the test results invalid. Your daughter should keep eating gluten daily until all testing is completed.

Are those the only blood tests they did? 

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Recent Activity

    1. - trents replied to Rebeccaj's topic in Super Sensitive People
      4

      symptoms.

    2. - knitty kitty replied to NCalvo822's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      3

      Newly Diagnosed

    3. - knitty kitty replied to Rebeccaj's topic in Super Sensitive People
      4

      symptoms.

    4. - Rebeccaj replied to Rebeccaj's topic in Super Sensitive People
      4

      symptoms.

    5. - knitty kitty replied to CeliacPI's topic in Related Issues & Disorders
      8

      Lymphocytic Colitis with Celiac


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      130,518
    • Most Online (within 30 mins)
      7,748

    Lois S
    Newest Member
    Lois S
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)

    • There are no registered users currently online

  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      Should not be a problem except for the most sensitive celiacs. The amount of gluten that would get in the air from cooking alone has got to be miniscule. I would be more concerned about cross contamination happening in other ways in a living environment where others are preparing and consuming gluten-containing foods. Thinks like shared cooking surfaces and countertops. And what about that toaster you mentioned?
    • knitty kitty
      Hello, @NCalvo822, Blood tests for Celiac Disease test for antibodies our bodies make in response to gluten exposure.  These Tg IgA 2 antibodies mistakenly attack our own bodies, causing problems in organs and tissues other than just the digestive tract.  Joints can ache, thyroid problems or the pancreas can develop.  Ataxia is just one of over two hundred symptoms of Celiac Disease. Some people with Celiac Disease also make tTg IgA 6 antibodies in response to gluten exposure.  The tTg IgA 6 antibodies attack the brain, causing ataxia.  These tTg IgA 6 antibodies are also found in people with Parkinson's disease, though they may not have Celiac Disease.  First degree relatives (parents, siblings, children) of those diagnosed with Celiac should be tested as well.  Celiac is genetic.  Your mom and sister should be tested for Celiac, too!   Definitely a good idea to keep to a gluten free diet.  
    • knitty kitty
      @Rebeccaj,  When you smell toast or pasta cooking, that means that particles of that food are floating around in the air.  Airborne gluten can then be inhaled and swallowed, meaning the food particles get into your digestive tract.   If you're careful to avoid gluten and are still having symptoms, those symptoms could be caused by vitamin deficiencies.  
    • Rebeccaj
      ok thanks for your advice. But my question was what happens when someone you know in a house is cooking pasta or toast that's flour  Airbourne without eating.?
    • knitty kitty
      Do discuss this recent article with your doctors.  Thiamine Vitamin B 1 is important to intestinal health.  Thiamine deficiency can occur in Celiac Disease due to malabsorption.  Supplementing with a B Complex, Benfotiamine, and Vitamin D can help symptoms.   Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages https://pubmed.ncbi.nlm.nih.gov/39890689/#:~:text=Our mechanistic study revealed that,necessary to protect against colitis. "Conclusion and implications: Our study provides evidence linking thiamine deficiency with proinflammatory macrophage activation and colitis aggravation, suggesting that monitoring thiamine status and adjusting thiamine intake is necessary to protect against colitis."
×
×
  • Create New...