HLA results

[RefiFed1]

Hi!  I have had GI symptoms since I had my gallbladder out 6 years ago.   Bloodwork and Endo negative but I just had my HLA test come back with this:

   The patient is positive and homozygous for DQB1*02.
I’m trying to understand what this means and it’s so confusing to read about it online.   
Any help would be appreciated.  

[trents]

Welcome to the forum, RefiRed1!

From: https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-19-88

"Celiac disease (celiac disease) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the triggering environmental factor, the gluten, and the main genetic factors, Human Leukocyte Antigen (HLA)-DQA1 and HLA-DQB1 loci, are well known. About 90-95% of celiac disease patients carry DQ2.5 heterodimers, encoded by DQA1*05 and DQB1*02 alleles both in cis or in trans configuration, and DQ8 molecules, encoded by DQB1*03:02 generally in combination with DQA1*03 variant. Less frequently, celiac disease occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers."

The linked article is dated, being from 2012. Since then, at least one other genetic marker has been discovered to be associated with celiac disease. Your genetic testing reveals that you have the gene potential for celiac disease (DQB1*0). But that does not equate to having or inevitably developing celiac disease, as about 40% of the population has the genetic potential and most do not develop the disease.

However, you may have NCGS (Non Celiac Gluten Sensitivity) for which there is no test. Celiac disease must first be ruled out. But both celiac disease and NCGS share many of the same symptoms and NCGS is 10x more common than celiac disease. Some experts feel that NCGS can be a precursor to celiac disease. The antidote for either is the same, lifelong total avoidance of gluten.

Edited April 5, 2023 by trents

[RefiFed1]

Thank you, I had been strictly gluten-free for a few years but with this new info feel I need to resume avoidance of all gluten more strictly.   I have some other autoimmune antibodies and feel my system is activated at this point.   Thank you for the warm welcome. 

[Wheatwacked]

Hi RefiFed1.

If you don't know what it is you should get your vitamin D blood level 25(OH)D checked.  Higher plasma levels of vitamin D moderates the immune system to control an overactive system. Low vitamin D allows the autoimmune system to run amuck.

Quote

 

Vitamin D deficiency is a common global issue. About 1 billion people worldwide have vitamin D deficiency, while 50% of the population has vitamin D insufficiency.

Approximately 35% of adults in the United States have vitamin D deficiency.

Vitamin D Deficiency

 

 

2 hours ago, RefiFed1 said:

I have some other autoimmune antibodies and feel my system is activated at this point.

The Little-Known Connection between Leaky Gut, Gluten Intolerance, and Gallbladder Problems "Sure enough, research has linked gluten intolerance and celiac disease to increased prevalence of gallstones and biliary cirrhosis."

Vitamin D and the Immune System "Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis... There is increasing epidemiologic evidence linking vitamin D deficiency and autoimmune diseases including multiple sclerosis (MS), rheumatoid arthritis (RA), diabetes mellitus (DM), inflammatory bowel disease and systemic lupus erythematosus... Vitamin D deficiency is prevalent in autoimmune disease."

Surge of information on benefits of vitamin D :

 

• A lifeguard study that found vitamin D levels in the 70 ng/mL range up to 100 ng/mL (nature’s level) were associated with no adverse effects;
• Data in patients with breast cancer showing a reduction in the incidence of new cancer with postulated 0 point at 80 ng/mL;
• Colon cancer data showing a reduction in the incidence of new cancer (linear) with postulated 0 point at 75 ng/mL;
• More than 200 polymorphisms of the vitamin D receptor requiring higher D levels to attain same desired outcomes;
• When a patient misses dosing, an attained level of 80 ng/mL gives the patient an additional month of good levels of of vitamin D.

 

[trents]

3 hours ago, RefiFed1 said:

Thank you, I had been strictly gluten-free for a few years but with this new info feel I need to resume avoidance of all gluten more strictly.   I have some other autoimmune antibodies and feel my system is activated at this point.   Thank you for the warm welcome. 

This may be helpful:

Studies have shown that most people who claim to be eating gluten free are really only eating "low gluten" because of being unaware of the myriad of ways and places gluten is hidden in the food supply. This was especially true of those frequenting restaurants. Truly eating gluten free requires education and diligence. It is also very possible, even likely, that you have develop intolerance to one or more other non gluten foods such as dairy, eggs or oats (even gluten free oats) due to the "leaky gut syndrome" that inevitably accompanies celiac disease.

Edited April 5, 2023 by trents