New Study Shows 36% Increase in Dementia Risk for PPI Users

[Scott Adams]

I thought this was an interesting long-term study on dementia risk for those who use proton pump inhibitors:

https://www.medscape.com/viewarticle/997244

[Wheatwacked]

"Further, the finding could signify a declining impact of individual risk factors with advancing age owing to lengthy ongoing neuropathological processes."

So people above 90 are already crazy so PPI use does not make them worse?

PPI use is a symptom of gastrointestinal issues, with its associated nutritional challenges of hypochlorhydria.

A good read all the same.

[knitty kitty]

This article covers more drugs which result in nutrient deficiencies.

Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874849/

 

[Blue-Sky]

Interesting article.

Some stomach issues such as h. pylori infection and GERD are largely caused by diet or aggravated by diabetes which is common. These affect insulin resistance and stomach bacteria which are both strongly related to dementia. 

"The risk for dementia before age 90 years was significantly higher among people with a history of proton pump inhibitor (PPI)"

But why are they using PPI before a certain age? Because of inflammation? A lot of other NCBI articles also seem to be that way that don't control for diet when it seems to me there is likely a very big connection.

Vitamin malabsorption is one complication of PPIs but so are changes in gut bacteria and insulin resistance.