Daughters Celiac Blood Results - would love insight

[Eightysix]

Hi all! I would love having your opinions on her blood work. She’s been referred to a gastroenterologist (which she will see Monday) but her blood work is confusing. 
 

A little background - she had had a dairy allergy since birth and continues to have stomach issues quite often. She will have to use the bathroom almost immediately during some meals and we can’t pinpoint exactly what causes it. My sister is gluten free after a lifetime of skin issues but does not have a formal celiac diagnosis and after going gluten-free, saw a decrease in her cholesterol and resolve of her Hashimotos.

 

DGA-Iga: 3 (0-19 normal)

DGA-igg: 1 (0-19 normal)

TTA-Iga: <2 (0-3 normal) 

Tissue Transglut Ab: 9 (0-5 normal)

Endomysial iga: negative 

Total Iga: 124 (51-220 normal)

 

her pediatrician declared it a positive result, hence the referral, but I’m unclear what, exactly, that positive test was measuring. Any thoughts?

[trents]

Eightysix, welcome to the forum!

The test abbreviations you post are different than we are used to seeing. The most common celiac antibody test ordered by physicians and the most well-rounded one is what we know to us as the tTG-IGA. I'm not sure which of your posted results would correspond to that. Would that be "TTA-Iga" or "Tissue Transglut ab"? 

Perhaps one of our other mods with more knowledge in this area can clear this up.

At any rate, the test results are mixed and not giving a clear indication of celiac disease but the one positive would seem to point to the possibility. The GI referral may be due to needing an endoscopy with biopsy of the small bowel lining to get a clearer answer. The biopsy looks for actual damage to the small bowel villi caused by celiac disease and is considered the gold diagnostic standard.

Edited October 28, 2023 by trents

[Eightysix]

2 minutes ago, trents said:

Eightysix, welcome to the forum!

The test abbreviations you post are different than we are used to seeing. The most common celiac antibody test ordered by physicians and the most well-rounded one is what we know to us as the tTG-IGA. I'm not sure which of your posted results would correspond to that. Would that be "TTA-Iga" or "Tissue Transglut ab"? 

Perhaps one of our other mods with more knowledge in this area can clear this up.

At any rate, the test results are mixed and not giving a clear indication of celiac disease but the one positive would seem to point to the possibility. The GI referral may by due to needing an endoscopy with biopsy of the small bowel lining to get a clearer answer. The biopsy looks for actual damage to the small bowel villi caused by celiac disease and is considered the gold diagnostic standard.

Yes, that was supposed to be “TTG-IgA”. I’m unclear what the “Tissue Transglut Ab” is, but that is how it appears on her test results! Thank you for your reply!

[Scott Adams]

This is just a guess, but the Tissue Transglut Ab: 9 (0-5 normal) might be the tTG-IgG (tissue transglutaminase IgG) Blood Test for Celiac Disease here:

 

There are two types of tissue transglutaminase tests, and perhaps she was positive on the IgG?