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Celiac Lab Work. 2.5 yr old

Ngueyn1980
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Ngueyn1980 Newbie
Ngueyn1980
Posted

My son is 2.5 years old. Symptoms are fluctuating diarrhea and constipation. Abdominal pain and bloating with vomiting. His labs game back as:

TISSUE TRANSGLUTAMINASE AB, IGA:

126.8 H

Reference Range: <15.0 U/mL 

GLIADIN (DEAMIDATED) AB (IGA):

<1.0

Reference Range: <15.0 U/mL 

GLIADIN (DEAMIDATED) AB (IGG):

6.3

Reference Range: <15.0 U/mL 

IMMUNOGLOBULIN A:

76

Reference Range: 20-99 mg/dL

ENDOMYSIAL ANTIBODY SCR (IGA) W/REFL TO TITER:

Positive

Reference Range: Negative

ENDOMYSIAL ANTIBODY TITER:

1:5

Reference Range: <1:5 titer

 

We have a GI appt on 12/2. I am hoping they will diagnose him with out an endoscopy. Poor little guy has been through so much already. 

 

 

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trents Grand Master
trents
Posted

Looks like he definitely has celiac disease from that high tTG-IGA and positive EMA. The tTG-IGA is considered the best all around antibody test for celiac disease, combining good sensitivity with good specificity. The EMA is less sensitive but is very specific for celiac disease. In some countries, i.e., the UK, if the tTG-IGA is 10x normal or greater they often will declare a celiac diagnosis without the endoscopy/biopsy. Your little guy fits that bill.

Scott Adams Grand Master
Scott Adams
Posted

I agree and this article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. 

 

 

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