Still ongoing....

[TheSootyShow]

Some of you might remember I started having tests two months ago, was told I had celiac and then the GP changed their mind and said she read the wrong test results. 

 

At my next appointment I pushed for more tests because I was feeling rubbish all the time still. 

Within the last week I have had a HLA at the hospital which the gastro team recommend. Awaiting the results for that, I'm not sure what this test even does?

In the last 2 months I have had 5 colds. My immune system has been kinda shitty and it's made me feel really low. I've been so tired all the time, my eyes physically burn by the end of the day and throughout the day where I feel exhausted even with "normal" amounts of sleep. If this latest blood test comes back fine, then I don't know what other things I should push for, because I know my body and it's not working how it should. Even if it's not gluten sensitivity or Celiac, then I don't even know where to go next with getting support and feeling better. 

 

Thanks 

 

[Wheatwacked]

If you could post your tests someone on the forum can give you a second opinion evaluation of their interpretation of them.  Test, result, range.

12 hours ago, TheSootyShow said:

My immune system has been kinda shitty and it's made me feel really low.

Your colds would be a strong indication of vitamin D deficiency and zinc deficiency. Even the NHS says: "Government advice is that everyone should consider taking a daily vitamin D supplement during the autumn and winter."  I've been taking 250 mcg a day (10,000 IU) since 2015 to keep my blood 25 hydroxy D level at 200 nmol/L (80 ng/ml).

As soon as you feel a cold coming on, zinc glyconate lozenge coats the mucous membranes. Zinc is the body's antiviral protection.  My last cold was May 2004.  "Zinc deficiency has been shown to increase the release of proinflammatory cytokines, such as interleukins IL-1β, IL-6, and tumor necrosis factor (TNF)-α .Zinc also has direct anti-viral properties. Zinc has been recognized as therapeutic against other upper respiratory pathogens, such as the common cold. It has been shown that increased intracellular zinc concentrations results in decreased SARS-COV-2 replication " Zinc Supplementation Associated With a Decrease

A good vitamin B complex, along with Choline supplements may help digestion and energy.

Celiac Disease causes malnutrition if not treated.  So do other food avoidance schemes.  While waiting to complete testing you should continue to eat a least 4 slices of bread.  Unfortunately, the sicker you are the greater chance of testing positive.  In the meantime it's never too early, or late, to start rectifying your multiple vitamin and mineral deficiencies, whatever the cause.

[Scott Adams]

Did you have an HLA blood test for genetic markers for celiac disease? This would only tell you if you are in the ~40% of people who have the genes that may include you in the pool of people who could develop celiac disease. 

[TheSootyShow]

2 hours ago, Scott Adams said:

Did you have an HLA blood test for genetic markers for celiac disease? This would only tell you if you are in the ~40% of people who have the genes that may include you in the pool of people who could develop celiac disease. 

I think that's the test I'm waiting upon to get back! 

[Scott Adams]

If you are having symptoms and suspect celiac disease, a more relevant test would be a celiac disease blood panel.

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.

 

 

[TheSootyShow]

1 minute ago, Scott Adams said:

If you are having symptoms and suspect celiac disease, a more relevant test would be a celiac disease blood panel.

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.

 

 

Thank you. I will have a look at that. I have had an Iga test and my results were as follows:

 

IGA

Immunoglobulin A level 3.06 g/L [0.8 - 2.8]; Above high reference limit.

So I dont have a deficiency! Do you know what it means to be over the reference limit? 

[Scott Adams]

An elevated IgA level can have various potential causes, and it is essential to consider the individual's medical history, symptoms, and overall health. Some possible reasons for high IgA levels include:

Infections: Chronic infections, particularly those affecting the respiratory or gastrointestinal tract, can lead to increased IgA production.

Autoimmune Disorders: Certain autoimmune diseases, such as rheumatoid arthritis or systemic lupus erythematosus, may be associated with elevated IgA levels.

Liver Disease: Liver conditions, including cirrhosis or hepatitis, can affect immunoglobulin levels.

Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis may result in elevated IgA levels.

Kidney Disease: Some forms of kidney disease can lead to changes in immunoglobulin levels.

Genetic Disorders: Certain genetic conditions can affect the production of immunoglobulins.

[TheSootyShow]

On 11/27/2023 at 4:48 PM, Wheatwacked said:

If you could post your tests someone on the forum can give you a second opinion evaluation of their interpretation of them.  Test, result, range.

Your colds would be a strong indication of vitamin D deficiency and zinc deficiency. Even the NHS says: "Government advice is that everyone should consider taking a daily vitamin D supplement during the autumn and winter."  I've been taking 250 mcg a day (10,000 IU) since 2015 to keep my blood 25 hydroxy D level at 200 nmol/L (80 ng/ml).

As soon as you feel a cold coming on, zinc glyconate lozenge coats the mucous membranes. Zinc is the body's antiviral protection.  My last cold was May 2004.  "Zinc deficiency has been shown to increase the release of proinflammatory cytokines, such as interleukins IL-1β, IL-6, and tumor necrosis factor (TNF)-α .Zinc also has direct anti-viral properties. Zinc has been recognized as therapeutic against other upper respiratory pathogens, such as the common cold. It has been shown that increased intracellular zinc concentrations results in decreased SARS-COV-2 replication " Zinc Supplementation Associated With a Decrease

A good vitamin B complex, along with Choline supplements may help digestion and energy.

Celiac Disease causes malnutrition if not treated.  So do other food avoidance schemes.  While waiting to complete testing you should continue to eat a least 4 slices of bread.  Unfortunately, the sicker you are the greater chance of testing positive.  In the meantime it's never too early, or late, to start rectifying your multiple vitamin and mineral deficiencies, whatever the cause.

For reference - the iga test and Serum alanine aminotransferase level are both high. Ttg iga was with in range. 

 

 

IGA

Immunoglobulin A level 3.06 g/L [0.8 - 2.8]; Above high reference limit

 

IGA ANTI-TISSUE TRANSGLUTAMINASE AN 0.66 U/mL [< 3.0]

Liver function tests

Serum albumin level 39 g/L [35.0 - 52.0]; New Albumin assay method and reference ranges

implemented 08/08/23

Serum alkaline phosphatase level 69 U/L [30.0 - 100.0]

Serum alanine aminotransferase level 139 U/L [0.0 - 35.0]; Above high reference limit

Serum total bilirubin level 8 umol/L [0.0 - 17.0]

 

 

Renal profile

Serum sodium level 142 mmol/L [132.0 - 146.0]

Serum potassium level 4.1 mmol/L [3.5 - 5.0]

Serum urea level 3.8 mmol/L [2.5 - 6.7]

Serum creatinine level 51 umol/L [45.0 - 84.0]

eGFR using creatinine (CKD-EPI) per 1.73 square metres > 90 mL/min/1.73m*2; eGFR is not valid in acute renal failure,

 

 

 

[Scott Adams]

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.