Don't understand results...

[wabjay]

Hi all, 

I've had awful acid reflux (lost voice for months a few times bc it burned vocal chords), fatigue, periodic stomach pain (bottom right), foggy brain for many years and after doing the whole 30 started doing a low-gluten diet, but cheat occasionally because I really love bread and don't really pay attention to contamination, etc. I had an old housemate with celiac and hers was really severe - even someone using the same pan to make a grilled cheese before her would cause really bad reactions - so I figured I couldn't possibly have it. Sometimes eating something with wheat doesn't do much to me at all, and I feel fine, while sometimes I feel awful!  But after my last few times having something wheat-based resulted in diarrhea, I asked my dr if we could do a gluten test to make sure I'm not doing long-term damage to myself when I'm not careful.

results were - deadimated gliadin iga and igg, both 3 (with reference interval 0-19); ttg iga <2 (with interval 0-3), ttg igg 26 (with reference interval 0-5), endomysial antibody negative, igg a serum 150 (interval 87-352).  So it looks like the only thing that's high is the ttg igg.  

My dr is out of town for the next week so now I'm wondering what, if anything, this tells me and if I should start being more careful.  Googling is just confusing me more.  Does anyone have any insight on what these could mean?

thank you!!

[trents]

Looks like there was no "total IGA" test run. If you are IGA deficient (low total IGA) then the negative tTG-IGA test result could be a false negative. The positive DGP-IGG certainly could indicate you have celiac disease and your symptoms certainly align with either celiac disease or NCGS (Non Celiac Gluten Sensitivity). Also, if you have been eating a low gluten diet that could cause false negatives in testing, especially in the tTG-IGA test.

[wabjay]

Hmmm! Thank you for the response.  Guess I have lots to talk abut with my doctor...  I appreciate the help! 

[Scott Adams]

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.

 

 

[wabjay]

Thank you, Scott!