New Celiac Drug Study Gives Insight Into Continuing Poor Nutrient Absorption Even After Going Gluten Free

[trents]

https://www.beyondceliac.org/research-news/potential-drug-to-treat-celiac-disease-prevents-damage-caused-by-gluten-in-recent-study-of-molecular-action/

Time will tell whether or not this new drug being tested proves to be effective and safe. There have been many attempts to develop a celiac drug that did not pan out. However, has been a valuable "spin off" insight gained in the process of this one, named ZED1227, which is designed to block TTG2:

“Blood antibody tests and traditional tissue tests do not necessarily tell the whole truth about the condition of the intestinal mucosa . . . previous studies have shown that even though the intestinal tissue may look healthy, it can still have a molecular scar. . . the expression of genes promoting the absorption of vitamins and trace elements may be deficient. This probably explains the often-observed deficiencies of trace elements in celiac patients despite a gluten-free diet . . .”

[RMJ]

Interesting.  Thanks for posting.

[Scott Adams]

I suspect this hidden damage is why my neurological issues didn't improve for decades, until I started more rigorous dietary supplementation.

[Scott Adams]

PS- It has come to my attention that this forum is criticized by other celiac Reddit boards and Facebook groups because of our emphasis on supplementation, but after 3 decades I'm convinced that a majority of celiacs will need extensive, lifelong supplementation to recover, and especially those who had Marsh 3 type villi damage.